- Systematic Target Screening Revealed That Tif302 Could Be an OffTarget of the Antifungal Terbinafine in Fission Yeast
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Lee S, Nam M, Lee AR, Lee J, Woo J, Kang NS, Balupuri A, Lee M, Kim SY, Ro H, Choi YW, Kim DU, Hoe KL
- KMID: 2513492
- Biomol Ther.
- 2021 Mar;29(2):234-247.
- doi: 10.4062/biomolther.2020.166
We used a heterozygous gene deletion library of fission yeasts comprising all essential and non-essential genes for a microarray screening of target genes of the antifungal terbinafine, which inhibits ergosterol... -
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- Inhibition of the Spectraplakin Protein Microtubule ActinCrosslinking Factor 1 Sensitizes Glioblastomas to Radiation
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Bonner K, Borlay D, Kutten O, Quick QA
- KMID: 2500121
- Brain Tumor Res Treat.
- 2020 Apr;8(1):43-52.
- doi: 10.14791/btrt.2020.8.e1
Background : Microtubule actin crosslinking factor 1 (MACF1) is a spectraplakin cytoskeletal crosslinking protein whose function and role in cancer biology has lacked investigation. Recent studies have identified MACF1 as a novel... -
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- Predicting the Benefit of Adjuvant Aromatase Inhibitor Therapy in Postmenopausal Breast Cancer Patients with Phosphorylated S6K1 Expression Status
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Choi J, Park CS, Seong MK, Seol H, Kim JS, Park IC, Noh WC, Kim HA
- KMID: 2470878
- J Breast Cancer.
- 2020 Feb;23(1):10-19.
- doi: 10.4048/jbc.2020.23.e5
PURPOSE: Phosphorylated ribosomal S6 kinase 1 (pS6K1) is a major downstream regulator of the mammalian target of rapamycin (mTOR) pathway. Recent studies have addressed the role of S6K1 in adipogenesis.... -
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- Phosphorylated S6 Kinase-1 as Predictive Marker of Lapatinib Efficacy in Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Patients
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Ko EB, Seong MK, Choi HS, Park CS, Choi JH, Lee JK, Seol H, Kim HA, Noh WC
- KMID: 2401816
- J Breast Dis.
- 2017 Dec;5(2):57-63.
- doi: 10.14449/jbd.2017.5.2.57
PURPOSE: The 40S ribosomal protein S6 kinase-1 (S6K1) is a crucial downstream effector of the PI3K/AKT/mTOR pathway. S6K1 overexpression is found in 10% to 30% of breast cancers and is... -
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- Molecular cloning and characterization of porcine ribosomal protein L21
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Sun WS, Chun JL, Kim DH, Ahn JS, Kim MK, Hwang IS, Kwon DJ, Hwang S, Lee JW
- KMID: 2398513
- J Vet Sci.
- 2017 Dec;18(4):531-540.
- doi: 10.4142/jvs.2017.18.4.531
Ribosomal protein L21 (RPL21) is a structural component of the 60S subunit of the eukaryotic ribosome. This protein has an important role in protein synthesis and the occurrence of hereditary... -
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- Ribosomal protein mutations in Korean patients with Diamond-Blackfan anemia
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Chae H, Park J, Lee S, Kim M, Kim Y, Lee JW, Chung NG, Cho B, Jeong DC, Kim J, Kim JR, Park G
- KMID: 2155353
- Exp Mol Med.
- 2014 Mar;46(3):e88.
- doi: 10.1038/emm.2013.159
Diamond-Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, associated physical malformations and a predisposition to cancer. DBA has been associated with mutations and deletions... -
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- Diagnosis of canine brucellosis using recombinant ribosomal protein L7/L12
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Lee HK, Kim JW, Ha YM, Her M, Kim JY, Lee K, Kang SI, Jung SC
- KMID: 1435796
- Korean J Vet Res.
- 2012 Mar;52(1):25-31.
Brucella (B.) canis is mainly transmitted by direct or indirect contact with aborted fetuses and placenta. It's also known to be able to infect human, which likely results in providing... -
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- Chlorogenic Acid Improves Neuroprotective Effect of PEP-1-Ribosomal Protein S3 Against Ischemic Insult
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Ahn EH, Kim DW, Shin MJ, Kwon SW, Kim YN, Kim DS, Lim SS, Kim J, Park J, Eum WS, Hwang HS, Choi SY
- KMID: 1495346
- Exp Neurobiol.
- 2011 Dec;20(4):169-175.
- doi: 10.5607/en.2011.20.4.169
Chlorogenic acid (CGA) possesses various biological activities such as anti-oxidant, anti-inflammatory, and anti-diabetic activities. In the present study, we examined the effect of CGA on the transduction efficiency of PEP-1-ribosomal... -
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