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Characterization of Echinostoma cinetorchis endoribonuclease, RNase H

Lim SB, Cha SH, Jegal S, Jun H, Park SH, Jeon BY, Pak JH, Bakh YY, Kim TS, Lee HW

Echinostoma cinetorchis is an oriental intestinal fluke causing significant pathological damage to the small intestine. The aim of this study was to determine a full-length cDNA sequence of E. cinetorchis...
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Molecular Defense Mechanisms during Urinary Tract Infection

Choi SY, Chang IH

The urinary tract is a common site of infection. The complete mechanisms of urinary tract infection (UTI) are still unknown. In general, the strategies of the uropathogenic Escherichia coli are...
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miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes

Makki MS, Haqqi TM

IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3' untranslated region (UTR) of...
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Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats

Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H

PURPOSE: Circular RNAs (circRNAs), a novel class of RNAs, perform important functions in biological processes. However, the role of circRNAs in the mammary gland remains unknown. The present study is...
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Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer

Park JL, Kim M, Song KS, Kim SY, Kim YS

MicroRNAs (miRNAs) have been demonstrated to play an important role in carcinogenesis. Previous studies revealed that miRNAs are present in human plasma in a remarkably stable form that is protected...
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Acne Inversa: Evaluating Antimicrobial Peptides and Proteins

Bechara FG, Sand M, Skrygan M, Kreuter A, Altmeyer P, Gambichler T

BACKGROUND: Acne inversa is a chronic, suppurative relapsing inflammatory skin disease that primarily affects the axillae, perineum and inframammary regions. Evidence suggests that the innate immune system is involved in...
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Quantitative Determination of Plasmodium Parasitemia by Flow Cytometry and Microscopy

Jun G, Lee JS, Jung YJ, Park JW

The traditional light microscopy has limitations for precise growth assays of malaria parasites in culture or for assessment of new compounds for antimalarial activity; the speed and high reproducibility of...
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MicroRNA-23a: A Novel Serum Based Diagnostic Biomarker for Lung Adenocarcinoma

Lee YM, Cho HJ, Lee SY, Yun SC, Kim JH, Lee SY, Kwon SJ, Choi E, Na MJ, Kang JK, Son JW

  • KMID: 2319540
  • Tuberc Respir Dis.
  • 2011 Jul;71(1):8-14.
BACKGROUND: MicroRNAs (miRNAs) have demonstrated their potential as biomarkers for lung cancer diagnosis. In recent years, miRNAs have been found in body fluids such as serum, plasma, urine and saliva....
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Enzyme Activity of Cenococcum geophilum Isolates on Enzyme-specific Solid Media

Obase K, Lee SY, Chun KW, Lee JK

  • KMID: 2312628
  • Mycobiology.
  • 2011 Jun;39(2):125-128.
Enzyme activities of Cenococcum geophilum isolates were examined on enzyme-specific solid media. Deoxyribonuclease, phosphatase, and urease were detected in all isolates, whereas cellulase was not detected in any of the...
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The effect of tumor necrosis factor (TNF)-alpha to induce matrix metalloproteinase (MMPs) from the human dental pulp, gingival, and periodontal ligament cells

Rhim EM, Park SH, Kim DS, Kim SY, Choi KK, Choi GW

OBJECTIVES: In the present study, three kinds of tissues cells (pulp, gingiva, and periodontal ligament) were investigated if those cells express MMP and TIMP when they were stimulated with neuropeptides...
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Association of RNase3 Polymorphisms with the Susceptibility of Gastric Cancer

Koo JW, Kang DB, Park WC, Lee YH, Kang IH, Chae SC, Lee JK

PURPOSE: RNase3 is a secretory ribonuclease, which is found in the eosinophilic leukocyte and involved in the innate immune system. Its cytotoxic activity is effective against a wide range of...
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Association of RNase3 Polymorphisms with the Risk of Colorectal Cancer

Kim Y, Kang DB, Lee JK, Lee YH, Kang IH, Chae SC, Yang YS, Park WC

PURPOSE: RNase3 is a secretory ribonuclease found in eosinophilic leukocytes and is involved in the innate immune system. Its cytotoxic activity is effective against a wide range of pathogens. Generally,...
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Tumor Necrosis Factor-Alpha Induced VCAM-l Expression is Inhibited by High Density Lipoprotein in Human Astroglioma Cells

Wagley Y, Oh JW

  • KMID: 2283439
  • Korean J Phys Anthropol.
  • 2008 Sep;21(3):225-233.
Astrocytes, the major glial cells in the central nervous system (CNS), can express vascular cell adhesion molecule-1(VCAM-1) in response to cytokines, such as TNF-alpha. In CNS, an increased VCAM-1 expression...
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Correlation Between Chemokine Production and Injury Type in Acute Brain Injury Patients

Chung JY, Do BS, Lee SB, Lee SH, Lee JY, Si JW, Lee SJ, Kim SH, Kim HS, Kim HY

  • KMID: 2331505
  • J Korean Soc Emerg Med.
  • 2007 Apr;18(2):124-133.
PURPOSE: Cytokines and chemokines are essential in neuronal development and play important roles in both acute and chronic inflammatory reactions in the central nerve system and peripheral tissues. Thus, they...
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Construction of an RNase P Ribozyme Library System for Functional Genomics Applications

Hong SW, Choi HJ, Lee YH, Lee DK

  • KMID: 2166248
  • Genomics Inform.
  • 2007 Mar;5(1):6-9.
An RNase P ribozyme library has been developed as a tool for functional genomics studies. Each clone of this library contains a random 18-mer and the sequence of M1 RNA,...
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Comparison of Inhibitory Potency of Various Antioxidants on the Activation of BV2 Microglial Cell Lines Induced by LPS

Kong PJ, Park JI, Kwon OY, Han YH, Kim SY, Lee SN, Son HJ, Kim SS

  • KMID: 1512912
  • Korean J Physiol Pharmacol.
  • 2007 Feb;11(1):9-13.
Antioxidant properties have been proposed as a mechanism for the putative anti-inflammatory effects of phenolic compounds. To reveal the relationship between antioxidant activity and anti-inflammatory effects of various antioxidants, we...
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Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells

Kwon D, Choi IH

The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing...
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The effect of neuropeptides on secretion of Interleukin-8 (IL-8)

Kim KJ, Park SH, Choi KK, Park SJ

We investigated the secretion of Interleukin-8 (IL-8) from ginviva and periodontal ligament stimulated with Substance P (SP) and Calcitonin Gene-related Peptide (CGRP). Gingiva (GF), periodontal ligament (PDLF) and pulp (PF)...
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Expression of Platelet Derived Growth Factor-A, C and Platelet Derived Growth Factor Receptor-alpha in the Ischemia Reperfusion Renal Failure Model

Kang KP, Kim W, Moon CY, Jang YB, Lee S, Moon SO, Sung MJ, kIm DH, Kang SK, Park SK

  • KMID: 2079574
  • Korean J Nephrol.
  • 2006 Jan;25(1):13-22.
BACKGOUND: Platelet-derived growth factor (PDGF) is a widely expressed growth factor with both mitogenic and chemotactic activities in many connective tissue cell types. There are four members of PDGF family;...
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Morphological Differences of the Wound Healing in Secretory Leukocyte Protease Inhibitor Knockout Mice

Jeong JO, Jeong SJ, Park JC, Kim HJ, SM W, Jeong MJ

  • KMID: 2283209
  • Korean J Phys Anthropol.
  • 2005 Sep;18(3):197-206.
Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor with anti-microbial properties found in mucosal fluids. At the tissue level, the ability of this 12kDa protein is to counteract...
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