- Liver Kinase B1 Mediates Its Anti-Tumor Function by Binding to the N-Terminus of Malic Enzyme 3
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Rho SB, Byun HJ, Kim BR, Lee CH
- KMID: 2541792
- Biomol Ther.
- 2023 May;31(3):330-339.
- doi: 10.4062/biomolther.2023.041
Liver kinase B1 (LKB1) is a crucial tumor suppressor involved in various cellular processes, including embryonic development, tumor initiation and progression, cell adhesion, apoptosis, and metabolism. However, the precise mechanisms... -
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- HPV-18 E7 Interacts with Elk-1 Leading to Elevation of the Transcriptional Activity of Elk-1 in Cervical Cancer
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Go SH, Rho SB, Yang DW, Kim BR, Lee CH, Lee SH
- KMID: 2534710
- Biomol Ther.
- 2022 Nov;30(6):593-602.
- doi: 10.4062/biomolther.2022.108
The human papillomavirus (HPV)-18 E7 (E7) oncoprotein is a major transforming protein that is thought to be involved in the development of cervical cancer. It is well-known that E7 stimulates... -
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- Snail Promotes Cancer Cell Proliferation via Its Interaction with the BIRC3
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Rho SB, Byun HJ, Kim BR, Lee CH
- KMID: 2531003
- Biomol Ther.
- 2022 Jul;30(4):380-388.
- doi: 10.4062/biomolther.2022.063
Snail is implicated in tumour growth and metastasis and is up-regulated in various human tumours. Although the role of Snails in epithelial-mesenchymal transition, which is particularly important in cancer metastasis,... -
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- Knockdown of LKB1 Sensitizes Endometrial Cancer Cells via AMPK Activation
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Rho SB, Byun HJ, Kim BR, Lee CH
- KMID: 2522253
- Biomol Ther.
- 2021 Nov;29(6):650-657.
- doi: 10.4062/biomolther.2021.131
Metformin is an anti-diabetic drug and has anticancer effects on various cancers. Several studies have suggested that metformin reduces cell proliferation and stimulates cell-cycle arrest and apoptosis. However, the definitive... -
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- PRR16/Largen Induces Epithelial-Mesenchymal Transition through the Interaction with ABI2 Leading to the Activation of ABL1 Kinase
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Kang GJ, Park JH, Kim HJ, Kim EJ, Kim B, Byun HJ, Yu L, Nguyen TM, Nguyen TH, Kim KS, Huy HP, Rahman M, Kim YH, Jang JY, Park MK, Lee H, Choi CI, Lee K, Han HK, Cho J, Rho SB, Lee CH
- KMID: 2530999
- Biomol Ther.
- 2022 Jul;30(4):340-347.
- doi: 10.4062/biomolther.2022.066
Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce... -
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- Loss of EMP2 Inhibits Melanogenesis of MNT1 Melanoma Cells via Regulation of TRP-2
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Enkhtaivan E, Kim HJ, Kim B, Byun HJ, Yu L, Nguyen TM, Nguyen TH, Do PA, Kim EJ, Kim KS, Huy HP, Rahman M, Jang JY, Rho SB, Lee H, Kang GJ, Park MK, Kim NH, Choi CI, Lee K, Han HK, Cho J, Lee AY, Lee CH
- KMID: 2526823
- Biomol Ther.
- 2022 Mar;30(2):203-211.
- doi: 10.4062/biomolther.2022.001
Melanogenesis is the production of melanin from tyrosine by a series of enzyme-catalyzed reactions, in which tyrosinase and DOPA oxidase play key roles. The melanin content in the skin determines... -
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- Suppressor of Variegation 3–9 Homolog 2, a Novel Binding Protein of Translationally Controlled Tumor Protein, Regulates Cancer Cell Proliferation
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Kim AR, Sung JY, Rho SB, Kim YN, Yoon K
- KMID: 2442016
- Biomol Ther.
- 2019 Feb;27(2):231-239.
- doi: 10.4062/biomolther.2019.021
Suppressor of Variegation 3–9 Homolog 2 (SUV39H2) methylates the lysine 9 residue of histone H3 and induces heterochromatin formation, resulting in transcriptional repression or silencing of target genes. SUV39H1 and... -
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- Novel Anti-Angiogenic and Anti-Tumour Activities of the N-Terminal Domain of NOEY2 via Binding to VEGFR-2 in Ovarian Cancer
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Rho SB, Lee KW, Lee SH, Byun HJ, Kim BR, Lee CH
- KMID: 2519616
- Biomol Ther.
- 2021 Sep;29(5):506-518.
- doi: 10.4062/biomolther.2021.121
The imprinted tumour suppressor NOEY2 is downregulated in various cancer types, including ovarian cancers. Recent data suggest that NOEY2 plays an essential role in regulating the cell cycle, angiogenesis and... -
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