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A Phase I/IIa Randomized Trial Evaluating the Safety and Efficacy of SNK01 Plus Pembrolizumab in Patients with Stage IV Non-Small Cell Lung Cancer

Kim EJ, Cho YH, Kim DH, Ko DH, Do EJ, Kim SY, Kim YM, Jung JS, Kang Y, Ji W, Choi MG, Lee JC, Rho JK, Choi CM

Purpose The aim of this study is to evaluate the safety and efficacy of ex vivo activated and expanded natural killer (NK) cell therapy (SNK01) plus pembrolizumab in a randomized...
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Predictive Factors for Switched EGFR-TKI Retreatment in Patients with EGFR-Mutant Non-Small Cell Lung Cancer

Kwon BS, Park JH, Kim WS, Song JS, Choi CM, Rho JK, Lee JC

BACKGROUND: Third-generation tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKIs) have proved efficacious in treating non-small cell lung cancer (NSCLC) patients with acquired resistance resulting from the T790M...
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An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib

Kwon T, Rho JK, Lee JC, Park YH, Shin HJ, Cho S, Kang YK, Kim BY, Yoon DY, Yu DY

Redox adaptation is an important concept that explains the mechanisms by which cancer cells survive under persistent endogenous oxidative stress and become resistant to certain anticancer agents. To investigate this...
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Incidence and Survival of Pediatric Soft Tissue Sarcomas: Comparison between Adults and Children

Lim SM, Yoo CJ, Han JW, Cho YJ, Kim SH, Ahn JB, Rha SY, Shin SJ, Chung HC, Yang WI, Shin KH, Rho JK, Kim HS

PURPOSE: Pediatric-type sarcomas such as rhabdomyosarcoma (RMS), Ewing sarcoma (EWS), primitive neuroectodermal tumor (PNET), and desmoplastic small round-cell tumor (DSRCT) are rare in adults, with limited studies on their prognosis...
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Neuroendocrine Differentiation in Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

Chang Y, Kim SY, Choi YJ, So KS, Rho JK, Kim WS, Lee JC, Chung JH, Choi CM

  • KMID: 2320446
  • Tuberc Respir Dis.
  • 2013 Sep;75(3):95-103.
BACKGROUND: Small cell lung cancer (SCLC) transformation during epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment in lung cancer has been suggested as one of possible resistance mechanisms. METHODS: We...
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Biodistribution of 99mTc Tricarbonyl Glycine Oligomers

Jang BS, Lee JS, Rho JK, Park SH

  • KMID: 1432306
  • Toxicol Res.
  • 2012 Dec;28(4):235-240.
99mTc tricarbonyl glycine monomers, trimers, and pentamers were synthesized and evaluated for their radiolabeling and in vivo distribution characteristics. We synthesized a 99mTc-tricarbonyl precursor with a low oxidation state (I)....
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Enhanced Sensitivity to Gefitinib after Radiation in Non-Small Cell Lung Cancer Cells

Choi YJ, Rho JK, Back DH, Kim HR, Lee JC, Kim CH

  • KMID: 2319561
  • Tuberc Respir Dis.
  • 2011 Oct;71(4):259-265.
BACKGROUND: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, gefitinib and erlotinib, are effective therapies for non-small cell lung cancer (NSCLC) patients whose tumors harbor somatic mutations in EGFR. The...
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Biphasic Increase of Pro-inflammatory Cytokines in Mice Lung after Irradiation

Choi YJ, Rho JK, Jang WS, Lee SJ, Lee SS, Koh JS, Kim JY, Kim HR, Kim CH, Lee JC

  • KMID: 2319186
  • Tuberc Respir Dis.
  • 2009 Jul;67(1):14-20.
BACKGROUND: The pathophysiologic mechanisms of radiation-induced lung injury should be elucidated to enhance the therapeutic efficacy of radiotherapy and to manage patients exposed to serious radiation by accident. It has...
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Clinical Features Reflect Exon Sites of EGFR Mutations in Patients with Resected Non-Small-Cell Lung Cancer

Na II, Rho JK, Choi YJ, Kim CH, Koh JS, Ryoo BY, Yang SH, Lee JC

The aim of the current study was to determine the clinical significance according to the subtypes of epidermal growth factor receptor (EGFR) mutations and presence of KRAS mutations in operable...
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Metastatic Model of Human Gastric Cancer by Orthotopic Transplantation

Kim YI, Hyung WJ, Chung HC, Lee MH, Rha SY, Rho JK, Noh SH

  • KMID: 2209477
  • J Korean Surg Soc.
  • 2002 Jul;63(1):30-34.
PURPOSE: The metastatic animal model of human cancer is important from a practical point of view in the research of cancer metastasis, because it resembles the original tumors morphologically, biologically...
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Measurement of Morphological Changes in Schizophrenic Patients using Brain Magnetic Resonance Imaging

Kim K, Rho JK, Ryu H

  • KMID: 1985341
  • Korean J Psychopharmacol.
  • 1998 Oct;9(2):143-152.
OBJECTIVES: This study was peformed to compare and measure the changes of corpus callosum of the schizophrenic patients with those of controls, to compare according to clinical symptoms, onset age....
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Brain Metastasis and Leptomeningeal Carcinomatosis in Breast Cancer

Chang YS, Seo JH, Lee R, Ahn JB, Shim KY, Gong SJ, Lee HY, Rha SY, Yoo NC, Suh CO, Kim JH, Rho JK, Lee KS, Min JS, Kim BS, Chung HC

  • KMID: 2329139
  • J Korean Cancer Assoc.
  • 1998 Jun;30(3):464-474.
PURPOSE: Brain metastasis is estimated to occur in 20 to 40% of cancer patients, and meningeal involvement has been reported in 5% to 8% of cancer patients. Even if the...
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The Effects of Mesima-Ex, the Immunomodulator in Curatively Resected Gastric Cancer

Cho SH, Kim JH, Park BK, Park SJ, Ahn SH, Jung HC, Rho JK, Kim BS, Rho SH

  • KMID: 2059147
  • J Korean Cancer Assoc.
  • 1997 Oct;29(5):800-806.
PURPOSE: The Mesima-Ex is a kind of biologic response modifier, which is extracted from a mushroom called Phellinus linteus. Mesima-Ex consists of various chemical compounds which include protein bound polysaccharide,...
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Factors related to Hospital Arrival Time of Acute Stroke Patients Who Visit Seoul National University Hospital

Cho YJ, Park BJ, Yoon BW, Chung JM, Cho JH, Rho JK

  • KMID: 2342556
  • J Korean Neurol Assoc.
  • 1996 Sep;14(3):696-703.
BACKGROUND & OBJECTIVE: Stroke Is a leading cause of death and disability in Korea. The management for the stroke should be given as soon as possible to be effective. We...
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Multimodal Approaches in the Patients with Stage I, II non-Hodgkin's Lymphoma of the Head and Neck

Pyo HR, Suh CO, Kim GE, Rho JK

  • KMID: 2196687
  • J Korean Soc Ther Radiol.
  • 1995 Jun;13(2):129-142.
PURPOSE: Traditionally the patients with early stage non-Hodgkin's lymphoma of he head and neck was treated with radiotherapy. But the results were not satisfactory due to distant relapse. Although combined...
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A Study on the Sleep Itisorder of a Part of Manufacturing Plant Workers

Rho JK, Yoo KH, Lee YS, Gho YC

  • KMID: 2074954
  • Korean J Occup Environ Med.
  • 1994 Sep;6(2):377-383.
This study was conducted to investigate sleep qualifies of manufacturing workers. The data were collected from the 479 manufacturing factory workers who were most 3 shift workers. The results obtained were...
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Crossed cerebello-cerebral diaschisis in cerebellar infraction

Rho JK, Kim MH, Lee MC, Yang HI, Kim JH, Lee KH

  • KMID: 1957352
  • J Korean Neurol Assoc.
  • 1993 Dec;11(4):498-504.
After supratentorial infarction. Crossed cerebellar diaschisis has been described. And there was also a report of crossed cerebral diaschisis in cerebellar infarction as a rare phenomenon. We analyzed 36 patients...
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The Effect of Lambert-Eaton Syndrome IgG on Calcium Current in Rat Chromaffin Cells

Seo DW, Lee KW, Rho JK, Lee SB, Myung HJ, Kim SJ, Goo YS, Kim J

  • KMID: 2138117
  • J Korean Neurol Assoc.
  • 1993 Jun;11(2):209-221.
In rat chromaffin cells persistent inward calcium currents which were evoked by depolarizing step pulses from holding potential of-80mV, increased to a maximum amplitude at around +lOmV, became smaller with...
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Congenital bronchoesophageal fistula without esophageal atresia in adult: report of one case

Yang SR, Eom SW, Kim NH, Rho JK, Lee CS

  • KMID: 1686265
  • Korean J Thorac Cardiovasc Surg.
  • 1992 Dec;25(12):1432-1435.
No abstract available.
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The influence of pathologic grade on adenoid cystic carcinoma

Kim KY, Choi JH, Rhim HY, Chung HC, Koh EH, Kim JH, Rho JK, Lee KB, Kim BS

  • KMID: 1694241
  • J Korean Cancer Assoc.
  • 1992 Aug;24(4):516-523.
No abstract available.
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