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Effect of the inhibition of phospholipase A2 in generation of free radicals in intestinal ischemia/reperfusion induced acute lung injury

Lee YM, Park YY, Kim T, Cho HG, Lee YJ, Repine JE

  • KMID: 2285220
  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):263-273.
The role of phospholipase A2 (PLA2) in acute lung leak induced by intestinal ischemia was investigated in association with neutrophilic respiratory burst. To induce lung leak, we generated intestinal ischemia for 60 min...
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The study for the roles of intratracheally administered histamine in the neutrophil-mediated acute lung injury in rats:

Koh Y, Hybertson , Jepson EK, Kim MJ, Lee IC, Lim CM, Lee SD, Kim WS, Kim DS, Kim WD, Repine JE

BACKGROUND: Neutrophils are considered to play critical roles in the development of acute respiratory distress syndrome. Histamine, which is distributed abundantly in lung tissue, increases the rolling of neutrophills via...
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