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Aldosterone Rapidly Enhances Levels of the Striatin and Caveolin-1 Proteins in Rat Kidney: The Role of the Mineralocorticoid Receptor

Inthachart K, Manotham K, Eiam-Ong S, Eiam-Ong S

BACKGROUND: Striatin and caveolin-1 (cav-1) are scaffolding/regulating proteins that are associated with salt-sensitive high blood pressure and promote renal sodium and water reabsorption, respectively. The mineralocorticoid receptor (MR) interacts with...
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Prognostic Effect of Guideline-Directed Therapy Is More Noticeable Early in the Course of Heart Failure

Ahn MS, Yoo BS, Yoon J, Lee SH, Kim JY, Ahn SG, Youn YJ, Lee JW, Son JW, Kim HS, Kang DR, Lee SE, Cho HJ, Lee HY, Jeon ES, Kang SM, Choi DJ, Cho MC

BACKGROUND: There have been few studies to evaluate the prognostic implications of guideline-directed therapy according to the temporal course of heart failure. This study assessed the relationship between adherence to...
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Mineralocorticoid receptor blockade for renoprotection

Cha DR

No abstract available.
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Antihypertensive effect of Ganjang (traditional Korean soy sauce) on Sprague-Dawley Rats

Mun EG, Sohn HS, Kim MS, Cha YS

BACKGROUND/OBJECTIVES: Although Korean fermented foods contain large amounts of salt, which is known to exacerbate health problems, these foods still have beneficial effects such as anti-hypertension, anti-cancer, and anti-colitis properties....
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Refractory and Resistant Hypertension: Antihypertensive Treatment Failure versus Treatment Resistance

Calhoun DA

Resistant hypertension has for many decades been defined as difficult-to-treat hypertension in order to identify patients who may benefit from special diagnostic and/or therapeutic considerations. Recently, the term "refractory hypertension"...
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Pseudohypoaldosteronism in a newborn male with functional polymorphisms in the mineralocorticoid receptor genes

Jeong HA, Park YK, Jung YS, Nam MH, Nam HK, Lee KH, Rhie YJ

Hyponatremia and hyperkalemia in infancy can be attributed to various causes, originating from a variety of renal and genetic disorders. Pseudohypoaldosteronism type 1 (PHA1) is one of these disorders, causing...
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Effect of aldosterone on epithelial-to-mesenchymal transition of human peritoneal mesothelial cells

Yu M, Shin HS, Lee HK, Ryu DR, Kim SJ, Choi KB, Kang DH

BACKGROUND: Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal dialysis. Epithelial-to-mesenchymal transition (EMT) of the peritoneum is an early and reversible mechanism of...
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Pseudohypoaldosteronism Type 1

Cheong HI

Pseudohypoaldosteronism (PHA), a rare syndrome of systemic or renal mineralocorticoid resistance, is clinically characterized by hyperkalemia, metabolic acidosis, and elevated plasma aldosterone levels with either renal salt wasting or hypertension....
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Effect of Eplerenone, a Selective Aldosterone Blocker, on the Development of Diabetic Nephropathy in Type 2 Diabetic Rats

Ahn JH, Hong HC, Cho MJ, Kim YJ, Choi HY, Eun CR, Yang SJ, Yoo HJ, Kim HY, Seo JA, Kim SG, Choi KM, Baik SH, Choi DS, Kim NH

BACKGROUND: Aldosterone antagonists are reported to have beneficial effects on diabetic nephropathy by effective blocking of the renin-angiotensin-aldosterone system. We investigated the renoprotective effect of the selective aldosterone receptor blocker...
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Evaluation of Pharmacokinetics and Tolerability of Eplerenone after Multiple Oral Doses of 100 mg in Healthy Korean Volunteers

Yoon S, Lee S, Oh DS, Lim KS, Shin SG, Jang IJ, Yu KS

  • KMID: 2334492
  • J Korean Soc Clin Pharmacol Ther.
  • 2011 Dec;19(2):84-90.
BACKGROUND: Eplerenone is a selective mineralocorticoid receptor antagonist which effectively blocks mineralocorticoid receptors in various tissues throughout the body. The addition of eplerenone to optimal medical therapy reduces morbidity and...
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Direct Corticosteroid Modulation of GABAergic Neurons in the Anterior Hypothalamic Area of GAD65-eGFP Mice

Shin SY, Han TH, Lee SY, Han SK, Park JB, Erdelyi F, Szabo G, Ryu PD

Corticosterone is known to modulate GABAergic synaptic transmission in the hypothalamic paraventricular nucleus. However, the underlying receptor mechanisms are largely unknown. In the anterior hypothalamic area (AHA), the sympathoinhibitory center...
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A case of pseudohypoaldosteronism type 1 with a mutation in the mineralocorticoid receptor gene

Lee SE, Jung YH, Han KH, Lee HK, Kang HG, Ha IS, Choi Y, Cheong HI

Pseudohypoaldosteronism type 1 (PHA1) is a rare form of mineralocorticoid resistance characterized in newborns by salt wasting with dehydration, hyperkalemia and failure to thrive. This disease is heterogeneous in etiology...
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Effects of Angiotensin II Type 2 Receptor on the Fibrosis of Diabetic Heart in the Otsuka Long-Evans Tokushima Fatty (OLETF) Rat

Choi CU, Park CG, Cha DR, Kim SH, Shin SY, Kim YK, Na JO, Kim JW, Lim HE, Kim EJ, Rha SW, Seo HS, Oh DJ

  • KMID: 1750376
  • J Korean Soc Hypertens.
  • 2010 Dec;16(4):19-29.
BACKGROUND: The objective of this study was to determine the effects of angiotensin II type 2 (AT2) receptor on the fibrosis of the diabetic heart and the hypertrophy of the...
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Decreased expression of Na,K-ATPase in the kidneys of rats with two-kidney, one-clip hypertension

Ma SK, Oh YW, Kim IJ, Bae EH, Lee JU, Kim SW

  • KMID: 2259162
  • Korean J Med.
  • 2010 Apr;78(4):477-484.
BACKGROUND/AIMS: This study investigated the role of Na,K-ATPase, the local renin-angiotensin-aldosterone system (RAAS), and atrial natriuretic peptide (ANP) system in the pathogenesis of renal tubular dysfunction and hypertension in rats...
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Increased Expression of Endothelin-1 and CYP11B2 in Gentamicin-Induced Nephropathy in Rat Kidney

Bae EH, Kim IJ, Oh YW, Bae WK, Park JW, Ma SK, Kim NH, Choi KC, Lee JU, Kim SH, Kim SW

  • KMID: 2253701
  • Korean J Nephrol.
  • 2007 Nov;26(6):660-668.
PURPOSE: An altered activity of vasoactive hormones as well as aldosterone synthase (CYP11B2) in the kidney may involve the pathogenesis of gentamicin-induced nephropathy. The present study was designed to investigate...
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A Case of Ectopic ACTH Syndrome Associated with Small Cell Lung Cancer Presented with Hypokalemia

Yang HJ, Sung HJ, Kim JE, Lee HJ, Park JM, Park CK, Roh ES, Cho JH, Ko SH, Song KH, Ahn YB

We report a case of a 73-year-old female patient who was diagnosed with ectopic ACTH syndrome caused by small cell lung cancer. We initially presumed that the patient was in...
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Hypertensive Hypokalemic Disorders

Choi KB

Hypokalemia is a common clinical problem. The kidney is responsible for long term potassium homoeostasis, as well as the serum potassium concentration. The main nephron site where K secretion is...
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Aldosterone Receptor Blockade Prevents Inflammatory Reaction on Type 2 Diabetic Nephropathy

Han SY, Kim CH, Ji YH, Han KH, Kang YS, Cha DR, Kim HS

  • KMID: 2307229
  • Korean J Nephrol.
  • 2005 Sep;24(5):691-698.
BACKGROUND: Aldosterone induces renal injury independent of angiotensin II. This harmful effect might be mediated via inflammatory reaction. Aldosterone receptor blockade can retard renal damage in various renal diseases including...
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Aldosterone Upregulates Connective Tissue Growth Factor Gene Expression via p38 MAPK Pathway and Mineralocorticoid Receptor in Ventricular Myocytes

Lee YS, Kim JA, Kim KL, Jang HS, Kim JM, Lee JY, Shin IS, Lee JS, Suh W, Choi JH, Jeon ES, Byun J, Kim DK

The effect of aldosterone on connective tissue growth factor (CTGF) was examined in rat embryonic ventricular myocytes. Upon aldosterone treatment, CTGF expression was significantly increased in a dose and time-dependent...
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Altered expression of sodium transporters in the excretory duct-ligated submandibular gland in rat

Oh YK, Ryu SY

  • KMID: 2183919
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2003 Nov;25(6):481-488.
Although acinar atrophy frequently occurs and the salivary secretory activity is significantly decreased in various salivary glandular diseases, their underlying molecular mechanisms have not been established. The present study was...
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