- MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
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Lee AJ, Cho KJ, Kim JH
- KMID: 2070275
- Exp Mol Med.
- 2015 Apr;47(4):e156.
- doi: 10.1038/emm.2015.8
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6... -
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- Leukotriene B4 pathway regulates the fate of the hematopoietic stem cells
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Chung JW, Kim GY, Mun YC, Ahn JY, Seong CM, Kim JH
- KMID: 1033100
- Exp Mol Med.
- 2005 Feb;37(1):45-50.
Leukotriene B4(LTB4), derived from arachidonic acid, is a potent chemotactic agent and activating factor for hematopoietic cells. In addition to host defense in vivo, several eicosanoids have been reported to... -
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- Leukotriene B(4) receptor 2 gene polymorphism (rs1950504, Asp196Gly) leads to enhanced cell motility under low-dose ligand stimulation
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Jang JH, Wei JD, Kim M, Kim JY, Cho AE, Kim JH
- KMID: 2396807
- Exp Mol Med.
- 2017 Nov;49(11):e402.
- doi: 10.1038/emm.2017.192
Recently, single-nucleotide polymorphisms (SNPs) in G-protein-coupled receptors (GPCRs) have been suggested to contribute to physiopathology and therapeutic effects. Leukotriene B4 receptor 2 (BLT2), a member of the GPCR family, plays... -
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- Low-dose UVB irradiation stimulates matrix metalloproteinase-1 expression via a BLT2-linked pathway in HaCaT cells
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Kim C, Ryu HC, Kim JH
- KMID: 1115267
- Exp Mol Med.
- 2010 Dec;42(12):833-841.
- doi: 10.3858/emm.2010.42.12.086
Skin exposure to low-dose ultraviolet B (UVB) light up-regulates the expression of matrix metalloproteinase-1 (MMP-1), thus contributing to premature skin aging (photo-aging). Although cyclooxygenase-2 (COX-2) and its product, prostaglandin E2... -
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- Up-regulation of BLT2 is critical for the survival of bladder cancer cells
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Seo JM, Cho KJ, Kim EY, Choi MH, Chung BC, Kim JH
- KMID: 1109401
- Exp Mol Med.
- 2011 Mar;43(3):129-137.
- doi: 10.3858/emm.2011.43.3.014
The incidence rates of urinary bladder cancer continue to rise yearly, and thus new therapeutic approaches and early diagnostic markers for bladder cancer are urgently needed. Thus, identifying the key... -
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- 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity
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Lee JW, Ryu HC, Ng YC, Kim C, Wei JD, Sabaratnam V, Kim JH
- KMID: 1383800
- Exp Mol Med.
- 2012 Jun;44(6):378-386.
12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. Despite the high level of 12-HHT present in tissues and bodily fluids,... -
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