- Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss
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Zhang X, Chen J, Gao Z, Qi H, Dai Y, She W
- KMID: 2462732
- Clin Exp Otorhinolaryngol.
- 2019 Nov;12(4):367-375.
- doi: 10.21053/ceo.2018.01298
OBJECTIVES: To investigate glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) gene expression and protein levels in peripheral blood mononuclear cells (PBMCs) of patients with severe or profound sudden sensorineural... -
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- NR3C1 Polymorphisms for Genetic Susceptibility to Schizophrenia
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Park JS, Lee SM, Kim JW, Kang WS
- KMID: 2469520
- Korean J Biol Psychiatry.
- 2019 Oct;26(2):88-93.
- doi: 10.0000/kjbp.2019.26.2.88
OBJECTIVES: Psychological stress has been known to increase the risk of schizophrenia. Because stress responses are mainly mediated by cortisol, the action of the glucocorticoid receptors (Nuclear Receptor Subfamily 3... -
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- Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway
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Kim SE, Ko IG, Ji ES, Jin JJ, Hwang L, Kim SH, Cho S, Kim CJ, Kim K, Kim KH
- KMID: 2448806
- Int Neurourol J.
- 2019 Feb;23(Suppl 1):S40-S49.
- doi: 10.5213/inj.1938048.024
PURPOSE: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. METHODS: BMAL1 knockdown transgenic... -
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- Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation
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Lee JS, Kim SR, Song JH, Lee YP, Ko HJ
- KMID: 2431676
- Osong Public Health Res Perspect.
- 2018 Dec;9(6):334-339.
- doi: 10.24171/j.phrp.2018.9.6.07
OBJECTIVES: Human rhinoviruses (HRVs) are the major cause of the common cold. Currently there is no registered, clinically effective, antiviral chemotherapeutic agent to treat diseases caused by HRVs. In this... -
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- Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation
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Ait-Belgnaoui A, Payard I, Rolland C, Harkat C, Braniste V, Théodorou V, Tompkins T
- KMID: 2417281
- J Neurogastroenterol Motil.
- 2018 Jan;24(1):138-146.
- doi: 10.5056/jnm16167
BACKGROUND/AIMS: Visceral pain and hypothalamic-pituitary-adrenal axis (HPA) dysregulation is a common characteristic in irritable bowel syndrome (IBS) patients. Previously, we reported that a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium... -
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- Mechanisms of Stress-induced Visceral Pain
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Greenwood-Van Meerveld B, Johnson AC
- KMID: 2417268
- J Neurogastroenterol Motil.
- 2018 Jan;24(1):7-18.
- doi: 10.5056/jnm17137
Evidence suggests that long-term stress facilitates visceral pain through sensitization of pain pathways and promotes chronic visceral pain disorders such as the irritable bowel syndrome (IBS). This review will describe... -
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- Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome
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Kim M, Lee HA, Cho HM, Kang SH, Lee E, Kim IK
- KMID: 2398552
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):23-33.
- doi: 10.4196/kjpp.2018.22.1.23
Cushing's syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors... -
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- Association of Serotonin 1A Receptor Polymorphism with Variation in Health-Related Quality of Life in Korean Hemodialysis Patients
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Park HC, Park S, Choi HY, Lee JE, Park HY, Kim SH, Ha SK, Seok JH
- KMID: 2387143
- Psychiatry Investig.
- 2017 Jul;14(4):506-512.
- doi: 10.4306/pi.2017.14.4.506
OBJECTIVE: Hemodialysis patients may have psychological distress and reduced quality of life (QoL) related to chronic physical health problems. Genetic polymorphisms associated with reduced QoL in hemodialysis patients. The aim... -
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- Effects of Cellular 11β-hydroxysteroid Dehydrogenase 1 on LPS-induced Inflammatory Responses in Synovial Cell Line, SW982
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Cho YS, Kim KN, Shim JH
- KMID: 2383355
- Immune Netw.
- 2017 Jun;17(3):171-178.
- doi: 10.4110/in.2017.17.3.171
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive cortisone into active cortisol, which has pleiotropic roles in various biological conditions, such as immunological and metabolic homeostasis. Cortisol is mainly... -
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- Changes in 11β-Hydroxysteroid Dehydrogenase and Glucocorticoid Receptor Expression in Kawasaki Disease
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Wang J, Zhou N, Wu S, Zhang X, Su D
- KMID: 2385392
- Korean Circ J.
- 2017 May;47(3):377-382.
- doi: 10.4070/kcj.2016.0257
BACKGROUND AND OBJECTIVES: This study aims to investigate the significance of changes in the expression 11β-hydroxysteroid dehydrogenase (11β-HSD) and glucocorticoid receptor (GR) for the development of Kawasaki disease (KD). SUBJECTS AND... -
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- Effect of Saccharin Intake in Restraint-induced Stress Response Reduction in Rats
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Park JM, Song MK, Kim YJ, Kim YJ
- KMID: 2173178
- J Korean Biol Nurs Sci.
- 2016 Feb;18(1):36-42.
- doi: 10.7586/jkbns.2016.18.1.36
PURPOSE: Stress activates the sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis and induces the release of glucocorticoids. Saccharin is 300 times sweeter than sucrose, but does not increase blood insulin... -
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- Selective Activator of the Glucocorticoid Receptor Compound A Dissociates Therapeutic and Atrophogenic Effects of Glucocorticoid Receptor Signaling in Skin
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Klopot A, Baida G, Bhalla P, Haegeman G, Budunova I
- KMID: 2380877
- J Cancer Prev.
- 2015 Dec;20(4):250-259.
- doi: 10.15430/JCP.2015.20.4.250
BACKGROUND: Glucocorticoids are effective anti-inflammatory drugs widely used in dermatology and for the treatment of blood cancer patients. Unfortunately, chronic treatment with glucocorticoids results in serious metabolic and atrophogenic adverse... -
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- The prognostic value of glucocorticoid receptors for adult acute lymphoblastic leukemia
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Bedewy AM, EL-Maghraby SM, Kandil NS, El-Bendary WR
- KMID: 2133758
- Blood Res.
- 2015 Dec;50(4):235-241.
- doi: 10.5045/br.2015.50.4.235
BACKGROUND: Therapeutic protocols used in adult acute lymphoblastic leukemia (ALL) are widely variable, and glucocorticoids (GCs) are essential components in ALL treatment. Therefore, this study aimed to evaluate the distribution... -
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- Mechanisms of Glucocorticoid Action in Chronic Rhinosinusitis
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Lee SH
- KMID: 2130259
- Allergy Asthma Immunol Res.
- 2015 Nov;7(6):534-537.
- doi: 10.4168/aair.2015.7.6.534
The innate immune system and its complex interplay with the adaptive immune system are increasingly being recognized as important factors in the pathogenesis of chronic rhinosinusitis (CRS). Adaptive immune components,... -
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- A Review of Postpartum Depression: Focused on Psychoneuroimmunological Interaction
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Kim Y, Ahn S
- KMID: 2307924
- Korean J Women Health Nurs.
- 2015 Jun;21(2):106-114.
- doi: 10.4069/kjwhn.2015.21.2.106
PURPOSE: The purpose of this review was to describe a psychoneuroimmunology (PNI) framework for postpartum depression (PPD) and discuss its implications for nursing research and practice for postpartum women. METHODS: This... -
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- Dexamethasone Inhibits Interleukin-1beta-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells
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Nam SI, Kwon TK
- KMID: 1973466
- Clin Exp Otorhinolaryngol.
- 2014 Sep;7(3):175-180.
- doi: 10.3342/ceo.2014.7.3.175
OBJECTIVES: To investigate the effect of interleukin (IL)-1beta on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1beta-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved. METHODS:... -
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- Sequential alterations of glucocorticoid receptors in the hippocampus of STZ-treated type 1 diabetic rats
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Shin JH, Seong JK, Yi SS
- KMID: 1737606
- J Vet Sci.
- 2014 Mar;15(1):19-26.
- doi: 10.4142/jvs.2014.15.1.19
Type 1 diabetes is a common metabolic disorder accompanied by increased blood glucose levels along with glucocorticoid and cognitive deficits. The disease is also thought to be associated with environmental... -
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- Involvement of Genetic and Environmental Factors in the Onset of Depression
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Nabeshima , Kim HC
- KMID: 2284626
- Exp Neurobiol.
- 2013 Dec;22(4):235-243.
- doi: 10.5607/en.2013.22.4.235
First, this article provides a brief overview of the previous hypotheses regarding depression and then focuses on involvement of genetic and environmental factors in development of depression. According to epidemiological... -
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- Depression as an Inflammatory Disease
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Song HR, Woo YS, Bahk WM
- KMID: 2287457
- Korean J Psychopharmacol.
- 2013 Jan;24(1):5-10.
Inflammation is an immune response engaged with the reciprocal interactions among the neural, endocrine and immune system. From this psychoneuroimmunological view, inflammation is one of important allostatic loads contributory to... -
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- Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
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Jeong JY, Jeoung NH, Park KG, Lee IK
- KMID: 2174390
- Diabetes Metab J.
- 2012 Oct;36(5):328-335.
- doi: 10.4093/dmj.2012.36.5.328
The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it... -
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