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Myocardial Protective Effect of Tezosentan, an Endothelin Receptor Antagonist, for Ischemia-Reperfusion Injury in Experimental Heart Failure Models

Ryu SM, Kim HJ, Cho KR, Jo WM

The myocardial protective effects of endothelin antagonist in ischemic cardiomyopathy (ICMP), doxorubicin-induced cardiomyopathy (DOX) and pressure-overload hypertrophy by transverse aortic constriction (TAC) models have been predicted to be different. The...
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Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema

Gamze K, Mehmet HM, Deveci F, Turgut T, ilhan F, Ozercan I

  • KMID: 1090964
  • Exp Mol Med.
  • 2007 Oct;39(5):614-620.
Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET related effects in various diseases, as well as in animal models of airway inflammation. We aimed to...
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