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Molecular Basis of Drug Resistance: Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Anaplastic Lymphoma Kinase Inhibitors

Yang SH

  • KMID: 2320467
  • Tuberc Respir Dis.
  • 2013 Nov;75(5):188-198.
Over the past decade, several kinase inhibitors have been approved based on their clinical benefit in cancer patients. Unfortunately, in many cases, patients develop resistance to these agents via secondary...
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Synergistic induction of cancer cell migration regulated by Gbetagamma and phosphatidylinositol 3-kinase

Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Woo DH, Lee HS, Ha HK, Bae SS

  • KMID: 1387359
  • Exp Mol Med.
  • 2012 Aug;44(8):483-491.
Phosphatidylinositol 3-kinase (PI3K) is essential for both G protein-coupled receptor (GPCR)- and receptor tyrosine kinase (RTK)-mediated cancer cell migration. Here, we have shown that maximum migration is achieved by full...
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