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The KIT Exon 11 Stop Codon Mutation in Gastrointestinal Stromal Tumors: What Is the Clinical Meaning?

Michelucci A, Chiappetta C, Cacciotti , Veccia N, Astri E, Leopizzi M, Prosperi Porta R, Petrozza V, Della Rocca C, Bevilacqua G, Cavazzana , Di Cristofano C

  • KMID: 2053513
  • Gut Liver.
  • 2013 Jan;7(1):35-40.
BACKGROUND/AIMS: Gastrointestinal stromal tumors (GISTs) strongly express a receptor tyrosine kinase (RTK, c-KIT-CD117) harboring a KIT mutation that causes constitutive receptor activation leading to the development and growth of tumors;...
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The Significance of Interstitial Cells in Neurogastroenterology

Blair PJ, Rhee PL, Sanders KM, Ward SM

  • KMID: 2381189
  • J Neurogastroenterol Motil.
  • 2014 Jul;20(3):294-317.
Smooth muscle layers of the gastrointestinal tract consist of a heterogeneous population of cells that include enteric neurons, several classes of interstitial cells of mesenchymal origin, a variety of immune...
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KIT/PDGFRA Expression and Mutation in Testicular Seminoma and Ovarian Dysgerminoma

Choi SY, Suh KS, Kim YB, Lee HJ, Kim ES, Park MJ

BACKGROUND: KIT and PDGFRA are tyrosine kinase receptors. Stem cell factor/KIT-mediated signaling plays a role in normal spermatogenesis, and the alteration of KIT is important in the pathogenesis of seminomas/dysgerminomas...
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Control of Motility in the Internal Anal Sphincter

Keef KD, Cobine CA

  • KMID: 2449091
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):189-204.
  • doi: 10.5056/jnm18172
The internal anal sphincter (IAS) plays an important role in the maintenance of fecal continence since it generates tone and is responsible for > 70% of resting anal pressure. During...
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Incidence and Causes of Hypereosinophilia in the Patients of a University Hospital

Kim DW, Shin MG, Yun HK, Kim SH, Shin JH, Suh SP, Ryang DW

BACKGROUND: Eosinophilia may be associated with various primary and reactive conditions. The incidence and the causes of eosinophilia might have been changed according to the changes in the incidence of...
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