- Increased Expression of Cathelicidin by Direct Activation of Protease-Activated Receptor 2: Possible Implications on the Pathogenesis of Rosacea
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Kim JY, Kim YJ, Lim BJ, Sohn HJ, Shin D, Oh SH
- KMID: 2070215
- Yonsei Med J.
- 2014 Nov;55(6):1648-1655.
- doi: 10.3349/ymj.2014.55.6.1648
PURPOSE: Recent findings of increased cathelicidin protein and its proteolytic fragments in rosacea suggest a pathogenic role for cathelicidin in this disease. The relationship between cathelicidin and protease-activated receptor 2... -
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- Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome
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Liang WJ, Zhang G, Luo HS, Liang LX, Huang D, Zhang FC
- KMID: 2411965
- Gut Liver.
- 2016 May;10(3):382-390.
- doi: 10.5009/gnl14319
BACKGROUND/AIMS: Previous studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS). The levels of... -
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- Protease and Protease-Activated Receptor-2 Signaling in the Pathogenesis of Atopic Dermatitis
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Lee SE, Jeong SK, Lee SH
- KMID: 1779625
- Yonsei Med J.
- 2010 Nov;51(6):808-822.
- doi: 10.3349/ymj.2010.51.6.808
Proteases in the skin are essential to epidermal permeability barrier homeostasis. In addition to their direct proteolytic effects, certain proteases signal to cells by activating protease-activated receptors (PARs), the G-protein-coupled... -
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- Stress-induced Alterations in Mast Cell Numbers and Proteinase-activated Receptor-2 Expression of the Colon: Role of Corticotrophin-releasing Factor
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Kim DH, Cho YJ, Kim JH, Kim YB, Lee KJ
- KMID: 1785913
- J Korean Med Sci.
- 2010 Sep;25(9):1330-1335.
- doi: 10.3346/jkms.2010.25.9.1330
This study was performed in order to assess whether acute stress can increase mast cell and enterochromaffin (EC) cell numbers, and proteinase-activated receptor-2 (PAR2) expression in the rat colon. In... -
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- Protease-Activated Receptor 2 Is Involved in Th2 Responses against Trichinella spiralis Infection
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Park MK, Cho MK, Kang SA, Park HK, Kim YS, Kim KU, Ahn SC, Kim DH, Yu HS
- KMID: 1715646
- Korean J Parasitol.
- 2011 Sep;49(3):235-243.
- doi: 10.3347/kjp.2011.49.3.235
In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2... -
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