- The effects of rebamipide, sucralfate, and rifaximin against inflammation and apoptosis in radiation-induced murine intestinal injury
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Moon W, Lim S, Jung Y, Heo YM, Park SJ, Park MI, Kim SE, Kim JH, Jung K
- KMID: 2538863
- Kosin Med J.
- 2022 Dec;37(4):320-341.
- doi: 10.7180/kmj.22.140
Background: Radiotherapy improves overall survival in patients with abdominopelvic malignancies. However, the toxic effects of radiation restrict the maximum dose that can be given, and there are no well-established preventive... -
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- The effect of rebamipide on non-steroidal anti-inflammatory drug-induced gastro-enteropathy: a multi-center, randomized pilot study
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Oh DJ, Yoon H, Kim HS, Choi YJ, Shin CM, Park YS, Kim N, Lee DH, Ha YJ, Kang EH, Lee YJ, Kim N, Kim KJ, Liu F
- KMID: 2535981
- Korean J Intern Med.
- 2022 Nov;37(6):1153-1166.
- doi: 10.3904/kjim.2021.216
Background/Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly-used medications, and ailments such as arthritis or heart disease, require long-term use of these drugs, which can induce gastroenteropathy with bleeding and ulcers.... -
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- Efficacy and Safety of Rebamipide versus Its New Formulation, AD-203, in Patients with Erosive Gastritis: A Randomized, DoubleBlind, Active Control, Noninferiority, Multicenter, Phase 3 Study
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Kim GH, Lee HL, Joo MK, Park HJ, Jung SW, Lee OJ, Kim H, Chun HJ, Lee ST, Kim JW, Jeon HH, Chung IK, Kim HS, Lee DH, Kim KO, Lim YJ, Park SJ, Cho SJ, Kim BW, Ko KH, Jeon SW, Kim JG, Sung IK, Kim TN, Sung JK, Park JJ
- KMID: 2522345
- Gut Liver.
- 2021 Nov;15(6):841-850.
- doi: 10.5009/gnl20338
Background/Aims: The mucoprotective drug rebamipide is used to treat gastritis and peptic ulcers. We compared the efficacy of Mucosta Ⓡ (rebamipide 100 mg) and its new formulation, AD-203 (rebamipide 150... -
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- The Efficacy of Rebamipide or Ecabet Sodium Supplementation for Helicobacter pylori Eradication Therapy Compared with Quadruple (Concomitant) Regimen
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Kim J, Kim K, Lee JS, Kim SY, Kim KO, Kim YJ, Kwon KA, Park DK, Chung JW
- KMID: 2409889
- Korean J Gastroenterol.
- 2018 Apr;71(4):204-212.
- doi: 10.4166/kjg.2018.71.4.204
BACKGROUND/AIMS: Although some previous studies reported that a treatment combined with mucoprotective agent could improve the eradication rate in dual or triple therapy, there are other reports that question the... -
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- Additive Effects of Rebamipide Plus Proton Pump Inhibitors on the Expression of Tight Junction Proteins in a Rat Model of Gastro-Esophageal Reflux Disease
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Gweon TG, Park JH, Kim BW, Choi YK, Kim JS, Park SM, Kim CW, Kim HG, Chung JW, Incheon and Western Kyonggi Gastrointestinal Study Group
- KMID: 2404716
- Gut Liver.
- 2018 Jan;12(1):46-50.
- doi: 10.5009/gnl17078
BACKGROUND/AIMS: The aim of this study was to investigate the effects of rebamipide on tight junction proteins in the esophageal mucosa in a rat model of gastroesophageal reflux disease (GERD). METHODS:... -
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- Metabolomics Approach to Explore the Effects of Rebamipide on Inflammatory Arthritis Using Ultra Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
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Moon SJ, Lee SH, Jung BH, Min JK
- KMID: 2389060
- J Rheum Dis.
- 2017 Aug;24(4):192-202.
- doi: 10.4078/jrd.2017.24.4.192
OBJECTIVE: Rebampide is a gastroprotective agent used to treat gastritis. It possesses anti-inflammatory and anti-arthritis effects, but the mechanisms of these effects are not well understood. The objective of this... -
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- The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study
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Hong SJ, Park SH, Moon JS, Shin WG, Kim JG, Lee YC, Lee DH, Jang JY, Kim JJ, Lee HL, Lee SW, Hwangbo Y, Xu J, Wang B, Xue Z, Liu F, Yuan Y, Leelakusolvong S, Dy F
- KMID: 2412096
- Gut Liver.
- 2016 Nov;10(6):910-916.
- doi: 10.5009/gnl15537
BACKGROUND/AIMS: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. METHODS: A total of 501 patients with reflux esophagitis were randomized into... -
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- Effects of Rebamipide on Gastrointestinal Symptoms in Patients with Type 2 Diabetes Mellitus
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Park S, Park SY, Kim YJ, Hong SM, Chon S, Oh S, Woo JT, Kim SW, Kim YS, Rhee SY
- KMID: 2308632
- Diabetes Metab J.
- 2016 Jun;40(3):240-247.
- doi: 10.4093/dmj.2016.40.3.240
BACKGROUND: Gastrointestinal (GI) symptoms are common in patients with type 2 diabetes mellitus (T2DM). Rebamipide is an effective gastric cytoprotective agent, but there are few data on its usefulness in... -
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- Preventive Efficacy and Safety of Rebamipide in Nonsteroidal Anti-Inflammatory Drug-Induced Mucosal Toxicity
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Kim JH, Park SH, Cho CS, Lee ST, Yoo WH, Kim SK, Kang YM, Rew JS, Park YW, Lee SK, Lee YC, Park W, Lee DH
- KMID: 1792359
- Gut Liver.
- 2014 Jul;8(4):371-379.
BACKGROUND/AIMS: The use of proton pump inhibitors or misoprostol is known to prevent the gastrointestinal complications of nonsteroidal anti-inflammatory drugs (NSAIDs). Rebamipide is known to increase the mucosal generation of... -
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- The Effect of Co-Administration of Rebamipide on the Expression of Serum Gastrin in Long-term Proton Pump Inhibitor Users: A Prospective Pilot Study
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Im EJ, Kim BW, Kim JS, Lee HM, Kim JI, Kang BK, Ji JS, Lee BI, Choi H
- KMID: 2305177
- Korean J Helicobacter Up Gastrointest Res.
- 2012 Mar;12(1):34-37.
- doi: 10.7704/kjhugr.2012.12.1.34
BACKGROUND/AIMS: In one animal study, co-administration of rebamipide with proton pump inhibitors (PPIs) could suppress hypergastrinemia but there have been no such reports on humans. The aim of this study... -
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- Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells
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Kang DW, Min G, Park DY, Hong KW, Min DS
- KMID: 1104382
- Exp Mol Med.
- 2010 Aug;42(8):555-564.
- doi: 10.3858/emm.2010.42.8.056
Rebamipide a gastroprotective drug, is clinically used for the treatment of gastric ulcers and gastritis, but its actions on gastric cancer are not clearly understood. Phospholipase D (PLD) is overexpressed... -
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- Rebamipide May Be Comparable to H2 Receptor Antagonist in Healing Iatrogenic Gastric Ulcers Created by Endoscopic Mucosal Resection: A Prospective Randomized Pilot Study
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Kim YJ, Cheon JH, Lee SK, Kim JH, Lee YC
- KMID: 1792929
- J Korean Med Sci.
- 2010 Apr;25(4):583-588.
- doi: 10.3346/jkms.2010.25.4.583
Endoscopic mucosal resection (EMR) results in the formation of iatrogenic gastric ulcers and the optimal treatments for such ulcers are still unclear. We aimed to evaluate the efficacy of rebamipide... -
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- Rebamipide Protects TNBS Induced Colonic Damage Through Down-regulation of NF-kappaB Activation and Induction of Heme Oxygenase -1 Expression
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Oh JM, Lee JR, Kwon YM, Kim YR, Kim KS, Choi MK, Chung YT
- KMID: 2030769
- Korean J Anat.
- 2005 Feb;38(1):31-38.
Crohn 's disease is characterized by a chronic relapsing inflammation of the bowel in which pro-inflammatory cytokines play an important role. Rebamipide is an anti-gastric ulcer drug with anti-inflammatory properties... -
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- Rebamipide Protects Colonic Damage Induced by Trinitrobenzene Sulfonic Acid (TNBS) via Down-Regulation of TNF-alpha IL-1beta and ICAM-1
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Kim YH, Kim SJ, Hwang HG, Choi SC, Kim YR, Kim KS, Kim C, Choi DH, Oh JT, Kim GD, Kim HW, Jun CD, Ryu CJ, Chung YT, Choi MK, Oh JM
- KMID: 2030759
- Korean J Anat.
- 2004 Apr;37(2):149-155.
During inflammation of the colon, cells of the gut mucosa produce or express numerous inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1 beta), and intercellular adhesion molecule 1... -
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- Therapeutic Effect of Rebamipide in Infertile Men with Oxidative Stress
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Shin DG, Oh GS, Park NC
- KMID: 1914749
- Korean J Urol.
- 2004 Apr;45(4):346-353.
PURPOSE: This study was performed to investigate whether rebamipide is useful in the treatment of male infertility due to oxidative damage. MATERIALS AND METHODS: 50 infertile males with elevated reactive oxygen... -
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- Antioxidative Effect of Rebamipide in Cryopreservation and Thawing of Sperm
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Park NC, Park E, Lee KM
- KMID: 2226689
- Korean J Androl.
- 2002 Aug;20(2):87-93.
PURPOSE: We performed this study to investigate the effects of adding rebamipide to cryoprotectant, to identify the improvement in sperm parameters by antioxidative action. MATERIALS AND METHODS: Semen samples from 30... -
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- The Antioxidant Effect of Rebamipide in Human Semen Specimens
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Park NC, Sim SB, Yan BQ, Cha CS, Ha HK
- KMID: 2292609
- Korean J Urol.
- 2002 Apr;43(4):332-338.
PURPOSE: Rebamipide is a propionic acid derivative that inhibits superoxide production and removes hydroxyl radicals. This study was performed to investigate the effects of adding rebamipide to semen, in an... -
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- Effect of Rebamipide on the Neutrophils Activated by Helicobacter pylori Water-Soluble Proteins
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Kim JS, Kim JM, Kim BG, Kim SG, Kim JW, Kim CG, Jung HC, Song IS
- KMID: 1606493
- Korean J Gastroenterol.
- 2002 Jan;39(1):13-21.
Background/Aims: Helicobacter pylori (H. pylori) infection induces persistent neutrophil infiltration in gastric mucosa. The expression of cyclooxygenase (COX)-2 and inhibition of apoptosis in the neutrophils could contribute to the pathogenesis... -
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- Effects of Rebamipide Against Nonsteroidal Anti-inflammatory Drugs (NSAIDs)Induced Gastroduodenal Mucosal Injury
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Seo YI, Park SH, Min DJ, Kim WU, Min JK, Lee SH, Hong YS, Cho CS, Kim HY
- KMID: 1768990
- J Korean Rheum Assoc.
- 2001 Jun;8(2):73-80.
OBJECTIVES: To investigate protective effect of rebamipide against nonsteroidal anti-inflammatory drugs (NSAIDs)induced gastroduodenal mucosal injury. METHODS: Randomized eight patients with rheumatic disease starting NSAIDs underwent pre-treatment gastroduodenoscopy,and degree of mucosal... -
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- Effect of Rebamipide (Mucosta(R)) in Eradication of Helicobacter pylori
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Lee DS, Ahn BM, Lee KM, Jeong HY, Lee MH, Chung IK, Roe IH, Nam SW, Lee JD
- KMID: 2084246
- Korean J Gastrointest Endosc.
- 2000 Nov;21(5):832-837.
BAKGROUND/AIMS: Eradication of Helicobacter pylori infection is highly efficacious in preventing the recurrence of peptic ulcer. Rebamipide (Mucosta(R)) is known to have the ability to inhibit neutrophil activity, to reduce... -
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