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The effects of naringenin and naringin on the glucose uptake and AMPK phosphorylation in high glucose treated HepG2 cells

Dayarathne LA, Ranaweera SS, Natraj P, Rajan P, Lee YJ, Han CH

Background: Naringin and its aglycone naringenin are citrus-derived flavonoids with several pharmacological effects. On the other hand, the mechanism for the anti-diabetic effects of naringenin and naringin are controversial and...
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Anti-adipogenic effect of the flavonoids through the activation of AMPK in palmitate (PA)-treated HepG2 cells

Rajan P, Natraj P, Ranaweera SS, Dayarathne LA, Lee YJ, Han CH

Objectives: The present study observed the anti-adipogenic effects of five major citrus flavonoids, including hesperidin (HES), narirutin (NAR), nobiletin (NOB), sinensetin (SIN), and tangeretin (TAN), on AMP-activated protein kinase (AMPK)...
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Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice

Ranaweera SS, Dissanayake CY, Natraj P, Lee YJ, Han CH

Background: Sulforaphane (SFN) is an isothiocyanate compound present in cruciferous vegetables. Although the anti-inflammatory effects of SFN have been reported, the precise mechanism related to the inflammatory genes is poorly...
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Restoration of the adipogenic gene expression by naringenin and naringin in 3T3-L1 adipocytes

Dayarathne LA, Ranaweera SS, Natraj P, Rajan P, Lee YJ, Han CH

Background: Naringenin and its glycoside naringin are well known citrus flavonoids with several therapeutic benefits. Although the anti-adipogenic effects of naringenin and naringin have been reported previously, the detailed mechanism...
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