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Epigenetic inactivation of RUNX3 in colorectal cancer

Shin EJ, Kim HJ, Son MW, Ahn TS, Lee HY, Lim DR, Bae SB, Jeon S, Kim H, Jeong D, Lee MS, Kim DS, Noh JS, Baek MJ

PURPOSE: Emerging evidence indicates that runt-related transcription factor 3 (RUNX3) is an important tumor suppressor gene in several cancer types, including colorectal cancer (CRC). However, the clinical significance of RUNX3...
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The Relationship between RUNX3 Inactivation and Its Pathological Features in Renal Cell Carcinoma

Kwon WA, Park C, Kim EJ, Ha YS, Kim YJ, Yun SJ, Lee SC, Kim WJ

  • KMID: 2311839
  • Korean J Urol.
  • 2009 May;50(5):432-438.
PURPOSE: DNA methylation is a key regulator of gene transcription and genomic stability, and alterations in DNA methylation are frequently detected in human tumors. Recent study has suggested that inactivation...
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Methylation of the Tumor Suppressor Gene RUNX3 in Human Gastric Carcinoma

Song HJ, Shim KN, Joo YH, Kim SE, Jung SA, Yoo K

  • KMID: 2135130
  • Gut Liver.
  • 2008 Sep;2(2):119-125.
BACKGROUND/AIMS: RUNX3 (PEBP2alphaC/CBFA3/AML2) is a novel tumor suppressor gene in the human gastric carcinoma. The aims of this study were to determine the methylation of RUNX3 promoter and the association...
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The Causal Relationship between RUNX3 and Bladder Tumor

Kim EJ, Kim WJ

  • KMID: 2293832
  • Korean J Urol.
  • 2005 Nov;46(11):1192-1198.
PURPOSE: We investigated the methylation pattern of RUNX3 to determine whether aberrant methylation events are risk factors for bladder tumor development, recurrence, and progression. MATERIALS AND METHODS: A hospital based, case-control...
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