- Inhibition of hepatitis B virus replication by RNA interference
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Park YG
- KMID: 1776809
- Korean J Hepatol.
- 2009 Mar;15(1):1-6.
- doi: 10.3350/kjhep.2009.15.1.1
No abstract available. -
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- RNA Interference in Functional Genomics and Medicine
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Kim VN
- KMID: 2157643
- J Korean Med Sci.
- 2003 Jun;18(3):309-318.
- doi: 10.3346/jkms.2003.18.3.309
RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded RNA (dsRNA). Being a highly specific and efficient knockdown technique, RNAi not only provides a powerful tool for functional... -
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- RNAi: A Recent Revolutionary Tool for Understanding of Basic Biology
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Jung DK, Cho YS, Lee WK
- KMID: 2224730
- Korean J Clin Microbiol.
- 2007 Apr;10(1):1-5.
RNA interference (RNAi) is a gene-silencing technology by which small double-stranded RNAs are used to target the degradation of RNA with complementary sequence. RNAi is found in a wide variety... -
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- The Blocking of TNF-alpha by RNA Interference and Its Influence on Synovial Fibroblast and Chondrocytes
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Kim HA
- KMID: 2334840
- J Korean Rheum Assoc.
- 2007 Dec;14(4):322-330.
OBJECTIVE: Small interfering RNA (siRNA) triggers RNA interference in mammalian somatic cells. TNF-alpha is a proinflammatory cytokine implicated in the pathogenesis of inflammatory arthritis including rheumatoid arthritis (RA). This study... -
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- Current Prospects of RNA Interference-based Therapy in Organ Transplantation
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Kim JY
- KMID: 2202582
- J Korean Soc Transplant.
- 2015 Sep;29(3):101-108.
- doi: 10.4285/jkstn.2015.29.3.101
RNA interference (RNAi) is a normal cellular process in which small RNAs control gene expression. siRNAs introduced into cells suppress gene expression through their recognition and cleavage of cognate mRNAs... -
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- Mobile transposon-like element, clone MTi7: Finding its role(s) by RNA interference
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Park CE, Shin MR, Jeon EH, Cho SW, Lee SH, Kim K, Kim NH, Lee KA
- KMID: 2304563
- Korean J Fertil Steril.
- 2003 Dec;30(4):299-307.
OBJECTIVES: The present study was conducted to evaluate the mobile transposon-like element, clone MTi7 (MTi7) expression in the mouse ovary and to determine its role(s) in the mouse oocytes by... -
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- The Effect of RNA Interference for TGF-beta1 Overexpression in Rat with Unilateral Ureteral Obstruction
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Kim HJ, Kim HC, Park KK
- KMID: 2307234
- Korean J Nephrol.
- 2005 Sep;24(5):739-748.
BACKGROUND: The progression of chronic renal diseases is an increasingly common condition, often leading to complete destruction of functional kidney tissue and dependency of affected individuals of life- long treatments... -
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- RNA Interference in Infectious Tropical Diseases
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Kang S, Hong YS
- KMID: 1720544
- Korean J Parasitol.
- 2008 Mar;46(1):1-15.
- doi: 10.3347/kjp.2008.46.1.1
Introduction of double-stranded RNA (dsRNA) into some cells or organisms results in degradation of its homologous mRNA, a process called RNA interference (RNAi). The dsRNAs are processed into short interfering... -
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- Effect of RNA Interference-Mediated Suppression of p75 on the Viability of Rat Notochordal Cells
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Park JB, Chang DG, Oh SY, Park EY
- KMID: 2362174
- Asian Spine J.
- 2016 Dec;10(6):985-992.
- doi: 10.4184/asj.2016.10.6.985
STUDY DESIGN: In vitro cell culture model. PURPOSE: To investigate the effects of RNA interference (RNAi) on p75 expression and viability of rat notochordal cells treated with serum deprivation. OVERVIEW OF LITERATURE:... -
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- The time-course and RNA interference of TNF-alpha, IL-6, and IL-1beta expression on neuropathic pain induced by L5 spinal nerve transection in rats
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Choi BM, Lee SH, An SM, Park DY, Lee GW, Noh GJ
- KMID: 2236156
- Korean J Anesthesiol.
- 2015 Apr;68(2):159-169.
- doi: 10.4097/kjae.2015.68.2.159
BACKGROUND: The objective of this study was to investigate the time-course of the expression of TNF-alpha, IL-6, and IL-1beta after L5 spinal nerve transection (SNT), and to determine the effect... -
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- Inactivation of the OD314 Gene by RNA Interference in Preodontoblast Cell Lines
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Kim HJ, Jeong MJ, Son HH, Park JC
- KMID: 2283179
- Korean J Phys Anthropol.
- 2004 Jun;17(2):121-129.
Tooth development depends on reciprocal interactions between oral epithelium and ectomesenchyme. The ectomesenchyme-derived odontoblasts secrete several collagenous and non-collagenous proteins to form a unique extracellular matrix. OD314 was obtained by... -
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- siMacro: A Fast and Easy Data Processing Tool for Cell-Based Genomewide siRNA Screens
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Singh NK, Seo BY, Vidyasagar M, White MA, Kim HS
- KMID: 1806272
- Genomics Inform.
- 2013 Mar;11(1):55-57.
- doi: 10.5808/GI.2013.11.1.55
Growing numbers of studies employ cell line-based systematic short interfering RNA (siRNA) screens to study gene functions and to identify drug targets. As multiple sources of variations that are unique... -
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- Inhibition of in vitro hepatitis B virus replication by lentivirus-mediated short-hairpin RNA against HBx
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Kim JW, Lee SH, Park YS, Jeong SH, Kim N, Lee DH
- KMID: 1776811
- Korean J Hepatol.
- 2009 Mar;15(1):15-24.
- doi: 10.3350/kjhep.2009.15.1.15
BACKGROUNDS/AIMS: Hepatitis B virus (HBV) replicates via RNA intermediates, which could serve as targets for RNA interference (RNAi). Vector-mediated short-hairpin RNA (shRNA) can induce sustained RNAi in comparison to small... -
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- Lin28 regulates the expression of neuropeptide Y receptors and oocyte-specific homeobox genes in mouse embryonic stem cells
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Park GT, Seo YM, Lee SY, Lee KA
- KMID: 1743696
- Clin Exp Reprod Med.
- 2012 Jun;39(2):87-93.
- doi: 10.5653/cerm.2012.39.2.87
OBJECTIVE: Lin28 has been known to control the proliferation and pluripotency of embryonic stem cells. The purpose of this study was to determine the downstream effectors of Lin28 in mouse... -
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- The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats
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Ki KH, Park DY, Lee SH, Kim NY, Choi BM, Noh GJ
- KMID: 1766501
- Korean J Anesthesiol.
- 2010 Dec;59(6):403-410.
- doi: 10.4097/kjae.2010.59.6.403
BACKGROUND: Small interfering RNAs (siRNAs) have been used to knockdown specific gene expression in various cells. Astrocytes and microglial cells play a key role in fundamental central nervous system functions... -
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- TGF-beta Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells
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Kang S, Min A, Im SA, Song SH, Kim SG, Kim HA, Kim HJ, Oh DY, Jong HS, Kim TY, Bang YJ
- KMID: 2380395
- Cancer Res Treat.
- 2015 Jan;47(1):101-109.
- doi: 10.4143/crt.2013.192
PURPOSE: Overexpression of cyclooxygenase 2 (COX-2) is thought to promote survival of transformed cells. Transforming growth factor beta (TGF-beta) exerts anti-proliferative effects on a broad range of epithelial cells. In... -
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- Hypoxia-inducible factor 1, hepatocellular carcinoma and angiogenesis
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Kim JW
- KMID: 1717321
- Korean J Hepatol.
- 2010 Sep;16(3):278-279.
- doi: 10.3350/kjhep.2010.16.3.278
No abstract available. -
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- Changes in gene expression associated with oocyte meiosis after Obox4 RNAi
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Lee HS, Kim EY, Lee KA
- KMID: 2045697
- Clin Exp Reprod Med.
- 2011 Jun;38(2):68-74.
- doi: 10.5653/cerm.2011.38.2.68
OBJECTIVE: Previously, we found that oocyte specific homeobox (Obox) 4 plays significant role in completion of meiosis specifically at meiosis I-meiosis II (MI-MII) transition. The purpose of this study was... -
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- Function of the pentose phosphate pathway and its key enzyme, transketolase, in the regulation of the meiotic cell cycle in oocytes
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Kim Y, Kim EY, Seo YM, Yoon TK, Lee WS, Lee KA
- KMID: 1743692
- Clin Exp Reprod Med.
- 2012 Jun;39(2):58-67.
- doi: 10.5653/cerm.2012.39.2.58
OBJECTIVE: Previously, we identified that transketolase (Tkt), an important enzyme in the pentose phosphate pathway, is highly expressed at 2 hours of spontaneous maturation in oocytes. Therefore, this study was... -
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- Small Interfering RNA–Mediated Suppression of Fas Modulate Apoptosis and Proliferation in Rat Intervertebral Disc Cells
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Park JB, Park C
- KMID: 2392649
- Asian Spine J.
- 2017 Oct;11(5):686-693.
- doi: 10.4184/asj.2017.11.5.686
STUDY DESIGN: In vitro cell culture model. PURPOSE: To investigate the effect of small interfering RNA (siRNA) on Fas expression, apoptosis, and proliferation in serum-deprived rat disc cells. OVERVIEW OF LITERATURE: Synthetic... -
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