- MicroRNA-21 promotes epithelial-mesenchymal transition and migration of human bronchial epithelial cells by targeting poly (ADP-ribose) polymerase-1 and activating PI3K/AKT signaling
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Zhang S, Sun P, Xiao X, Hu Y, Qian Y, Zhang Q
- KMID: 2530943
- Korean J Physiol Pharmacol.
- 2022 Jul;26(4):239-253.
- doi: 10.4196/kjpp.2022.26.4.239
Epithelial-mesenchymal transition (EMT ) is known to be involved in airway remodeling and fibrosis of bronchial asthma. However, the molecular mechanisms leading to EMT have yet to be fully clarified.... -
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- RNA interference as a novel treatment strategy for chronic hepatitis B infection
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Hui RWH, Mak LY, Seto WK, Yuen MF
- KMID: 2531368
- Clin Mol Hepatol.
- 2022 Jul;28(3):408-424.
- doi: 10.3350/cmh.2022.0012
Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality. Functional cure of CHB, defined as sustainable hepatitis B surface antigen (HBsAg) seroclearance, is associated with improved... -
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- Expression of miR-221 and miR-18a in patients with hepatocellular carcinoma and its clinical significance
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Yun JH, Baek MJ, Jung HI
- KMID: 2531833
- Korean J Clin Oncol.
- 2022 Jun;18(1):17-26.
- doi: 10.14216/kjco.22003
Purpose: Recently, microRNA (miRNA) has been evaluated to provide a new diagnostic and therapeutic modality hepatocellular carcinoma (HCC) and other tumors. They are small non-coding RNA molecules that function as... -
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- Transcriptomic Analysis of Papillary Thyroid Cancer: A Focus on Immune-Subtyping, Oncogenic Fusion, and Recurrence
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Park SJ, Kang YE, Kim JH, Park JL, Kim SK, Baek SW, Chu IS, Yi S, Lee SE, Park YJ, Chung EJ, Kim JM, Ko HM, Kim JR, Jung SN, Won HR, Chang JW, Koo BS, Kim SY
- KMID: 2530165
- Clin Exp Otorhinolaryngol.
- 2022 May;15(2):183-193.
- doi: 10.21053/ceo.2021.02215
Objectives. Thyroid cancer is the most common endocrine tumor, with rapidly increasing incidence worldwide. However, its transcriptomic characteristics associated with immunological signatures, driver fusions, and recurrence markers remain unclear. We... -
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- Implication of microRNA as a potential biomarker of myocarditis
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Oh JH, Kim GB, Seok H
- KMID: 2529553
- Clin Exp Pediatr.
- 2022 May;65(5):230-238.
- doi: 10.3345/cep.2021.01802
Myocarditis was previously attributed to an epidemic viral infection. Additional harmful reagents, in addition to viruses, play a role in its etiology. Coronavirus disease 2019 (COVID-19) vaccine-induced myocarditis has recently... -
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- Single-Cell RNA Sequencing of Bone Marrow Mesenchymal Stem Cells from the Elderly People
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Zhu D, Gao J, Tang C, Xu Z, Sun T
- KMID: 2529789
- Int J Stem Cells.
- 2022 May;15(2):173-182.
- doi: 10.15283/ijsc21042
Background and Objectives: Bone marrow mesenchymal stem cells (BMSCs) show considerable promise in regenerative medicine. Many studies demonstrated that BMSCs cultured in vitro were highly heterogeneous and composed of diverse... -
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- Inhibitory effect of water-soluble mulberry leaf extract on hepatic lipid accumulation in high-fat diet-fed rats via modulation of hepatic microRNA-221/222 expression and inflammation
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Lee MS, Kim C, Ko H, Kim Y
- KMID: 2529467
- J Nutr Health.
- 2022 Apr;55(2):227-239.
- doi: 10.4163/jnh.2022.55.2.227
Purpose: This study investigated the effects of water-soluble mulberry leaf extract (ME) on hepatic lipid accumulation in high-fat diet-fed rats via the regulation of hepatic microRNA (miR)-221/222 and inflammation. Methods: Male... -
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- A Case of Myocarditis Presenting With a Hyperechoic Nodule After the First Dose of COVID-19 mRNA Vaccine
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Park S, You J
- KMID: 2529296
- J Korean Med Sci.
- 2022 Apr;37(16):e131.
- doi: 10.3346/jkms.2022.37.e131
Myocarditis and/or pericarditis have been reported as adverse events following coronavirus disease 2019 (COVID-19) messenger RNA vaccination, with most cases occurring within 1 week after the second dose. We report... -
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- TcellInflamedDetector: an R package to distinguish T cell inflamed tumor types from non–T cell inflamed tumor types
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Yang SD, Park HS
- KMID: 2527956
- Genomics Inform.
- 2022 Mar;20(1):e13.
- doi: 10.5808/gi.22005
A major issue in the use of immune checkpoint inhibitors is their lack of efficacy in many patients. Previous studies have reported that the T cell inflamed signature can help... -
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- Improving siRNA design targeting nucleoprotein gene as antiviral against the Indonesian H5N1 virus
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Hartawan R, Pujianto DA, Dharmayanti NLPI, Soebandrio A
- KMID: 2527883
- J Vet Sci.
- 2022 Mar;23(2):e24.
- doi: 10.4142/jvs.21174
Background: Small interfering RNA technology has been considered a prospective alternative antiviral treatment using gene silencing against influenza viruses with high mutations rates. On the other hand, there are no reports... -
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- Morphological and Molecular Characterization of Philometroides seriolae from Japanese Amberjack Seriola quinqueradiata caught in East Sea, Republic of Korea
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Choe S, Eom KS
- KMID: 2526674
- Korean J Parasitol.
- 2022 Feb;60(1):45-49.
- doi: 10.3347/kjp.2022.60.1.45
The Japanese amberjack Seriolae quinqueradiata is one of the most consumed fish species among the Koreans. However, information regarding parasitic infection in Japanese amberjack is scarce. This study described the... -
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- Transcriptome profiling identifies immune response genes against porcine reproductive and respiratory syndrome virus and Haemophilus parasuis co-infection in the lungs of piglets
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Zhang J, Wang J, Zhang X, Zhao C, Zhou S, Du C, Tan Y, Zhang Y, Shi K
- KMID: 2525542
- J Vet Sci.
- 2022 Jan;23(1):e2.
- doi: 10.4142/jvs.21139
Background: Co-infections of the porcine reproductive and respiratory syndrome virus (PRRSV) and the Haemophilus parasuis (HPS) are severe in Chinese pigs, but the immune response genes against co-infected with 2... -
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- Vinyl-Stilbene Inhibits Human Norovirus RNA Replication by Activating Heat-Shock Factor-1
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Lee A, Sung J, Harmalkar DS, Kang H, Lee H, Lee K, Lee C
- KMID: 2524148
- Biomol Ther.
- 2022 Jan;30(1):64-71.
- doi: 10.4062/biomolther.2021.153
Norovirus (NV) is the most common cause of viral gastroenteritis, with the potential to develop into a fatal disease in those who are immuno-compromised, and effective vaccines and treatments are... -
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- Profiling of RNA-binding Proteins Interacting With Glucagon and Adipokinetic Hormone mRNAs
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Ko S, Yeom E, Chun YL, Mun H, Howard-McGuire M, Millison NT, Jung J, Lee KP, Lee C, Lee KS, Delaney JR, Yoon JH
- KMID: 2525230
- J Lipid Atheroscler.
- 2022 Jan;11(1):55-72.
- doi: 10.12997/jla.2022.11.1.55
Objective: Glucagon in mammals and its homolog (adipokinetic hormone [AKH] in Drosophila melanogaster) are peptide hormones which regulate lipid metabolism by breaking down triglycerides. Although regulatory mechanisms of glucagon and... -
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- High-performance computing for SARS-CoV-2 RNAs clustering: a data science‒based genomics approach
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Oujja A, Abid MR, Boumhidi J, Bourhnane S, Mourhir A, Merchant F, Benhaddou D
- KMID: 2524340
- Genomics Inform.
- 2021 Dec;19(4):e49.
- doi: 10.5808/gi.21056
Nowadays, Genomic data constitutes one of the fastest growing datasets in the world. As of 2025, it is supposed to become the fourth largest source of Big Data, and thus... -
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- An in-silico approach to design potential siRNAs against the ORF57 of Kaposi’s sarcoma-associated herpesvirus
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Rahman A, Gupta SD, Rahman MA, Tamanna S
- KMID: 2524338
- Genomics Inform.
- 2021 Dec;19(4):e47.
- doi: 10.5808/gi.21057
Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few human oncogenic viruses, which causes a variety of malignancies, including Kaposi's sarcoma, multicentric Castleman disease, and primary effusion lymphoma, particularly in... -
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- Development of an RNA sequencing panel to detect gene fusions in thyroid cancer
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Kim D, Jung SH, Chung YJ
- KMID: 2524332
- Genomics Inform.
- 2021 Dec;19(4):e41.
- doi: 10.5808/gi.21061
In addition to mutations and copy number alterations, gene fusions are commonly identified in cancers. In thyroid cancer, fusions of important cancer-related genes have been commonly reported; however, extant panels... -
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- Hair Growth Promoting Effects of 650 nm Red Light Stimulation on Human Hair Follicles and Study of Its Mechanisms via RNA Sequencing Transcriptome Analysis
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Yang K, Tang Y, Ma Y, Liu Q, Huang Y, Zhang Y, Shi X, Zhang L, Zhang Y, Wang J, Zhu Y, Liu W, Tan Y, Lin J, Wu W
- KMID: 2522134
- Ann Dermatol.
- 2021 Dec;33(6):553-561.
- doi: 10.5021/ad.2021.33.6.553
Background: Androgenetic alopecia (AGA) leads to thinning of scalp hair and affects 60%~70% of the adult population worldwide. Developing more effective treatments and studying its mechanism are of great significance.... -
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- Effects of mulberry fruit juice powder on inflammation and microRNA-132/143 regulation in 3T3-L1 adipocytes
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Lee MS, Kim Y
- KMID: 2522197
- J Nutr Health.
- 2021 Oct;54(5):448-458.
- doi: 10.4163/jnh.2021.54.5.448
Purpose: Mulberry (Morus alba L.) fruit is widely grown in Asia and consumed as fresh fruit, jam, and juices. The fruit has beneficial health effects, including anti-diabetic, anti-tumor, and anti-obesity... -
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- Long Noncoding-RNA Component of Mitochondrial RNA Processing Endoribonuclease Promotes Carcinogenesis in Triple-Negative Breast Cancer Cells via the Competing Endogenous RNA Mechanism
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Qi L, Sun B, Yang B, Lu S
- KMID: 2522094
- J Breast Cancer.
- 2021 Oct;24(5):428-442.
- doi: 10.4048/jbc.2021.24.e42
Purpose: Triple-negative breast cancer (TNBC) is a subtype of breast cancer. Increasing evidence supports that dysregulation of long noncoding RNAs (lncRNAs) plays a vital role in cancer progression. RNA component... -
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