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Efficacy of Palonosetron vs. Ramosetron for the Prevention of Postoperative Nausea and Vomiting: A Meta-Analysis of Randomized Controlled Trials

Kim MS, Park JH, Choi YS, Park SH, Shin S

PURPOSE: This study was designed as a meta-analysis of randomized controlled trials (RCTs) that included the comparison of palonosetron and ramosetron for postoperative nausea and vomiting (PONV) prophylaxis. MATERIALS AND METHODS:...
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Palonosetron versus granisetron in combination with aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with gynecologic cancer

Fujiwara S, Terai Y, Tsunetoh S, Sasaki H, Kanemura M, Ohmichi M

OBJECTIVE: There is no research regarding the appropriate antiemetic agents for female patients, especially those receiving moderately emetogenic chemotherapy (MEC). We evaluated the antiemetic efficacy of a combination of 5-HT3...
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Effect of Improvement in Lower Urinary Tract Symptoms on Sexual Function in Men: Tamsulosin Monotherapy vs. Combination Therapy of Tamsulosin and Solifenacin

Ko K, Yang DY, Lee WK, Kim SW, Moon DG, Moon KH, Park NC, Park JK, Son HC, Lee SW, Hyun JS, Park K

PURPOSE: To evaluate how much the improvement of lower urinary tract symptoms (LUTS) affects sexual function and which storage symptoms or voiding symptoms have the greatest effect on sexual function. MATERIALS...
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Palonosetron has superior prophylactic antiemetic efficacy compared with ondansetron or ramosetron in high-risk patients undergoing laparoscopic surgery: a prospective, randomized, double-blinded study

Kim SH, Hong JY, Kim WO, Kil HK, Karm MH, Hwang JH

BACKGROUND: Postoperative nausea and vomiting (PONV) continues to be a major problem, because PONV is associated with delayed recovery and prolonged hospital stay. Although the PONV guidelines recommended the use...
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Effects of Palonosetron, a 5-HT3 Receptor Antagonist, on Mechanical Allodynia in a Rat Model of Postoperative Pain

Jung KT, Yoon MH, Lee HY, Yu BY, Kim DK, Lim KJ

BACKGROUND: 5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or...
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A randomized, double-blind study to evaluate the efficacy of ramosetron and palonosetron for prevention of postoperative nausea and vomiting after gynecological laparoscopic surgery

Park SK, Cho EJ, Kang SH, Lee YJ, Kim DA

BACKGROUND: Postoperative nausea and vomiting (PONV) is a common complication after anesthesia and surgery; 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have been considered as a first-line therapy. Ramosetron and palonosetron...
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Comparison of palonosetron with ondansetron in prevention of postoperative nausea and vomiting in patients receiving intravenous patient-controlled analgesia after gynecological laparoscopic surgery

Kim YY, Moon SY, Song DU, Lee KH, Song JW, Kwon YE

BACKGROUND: Postoperative nausea and vomiting (PONV) are common complications after anesthesia and surgery. This study was designed to compare the effects of palonosetron and ondansetron in preventing PONV in high-risk...
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Rationale for the Use of Anticholinergic Agents in Overactive Bladder With Regard to Central Nervous System and Cardiovascular System Side Effects

Cetinel B, Onal B

  • KMID: 2315935
  • Korean J Urol.
  • 2013 Dec;54(12):806-815.
PURPOSE: Central nervous system (CNS) and cardiovascular system (CVS) side effects of anticholinergic agents used to treat overactive bladder (OAB) are underreported. Hence, this review aimed to focus on the...
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Intravenous palonosetron increases the incidence of QTc prolongation during sevoflurane general anesthesia for laparotomy

Min JJ, Yoo Y, Kim TK, Lee JM

BACKGROUND: Palonosetron is a recently introduced 5-hydroxytryptamine-3 (5-HT3) receptor antagonist useful for postoperative nausea and vomiting prophylaxis. However, 5-HT3 receptor antagonists increase the corrected QT (QTc) interval in patients who...
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Efficacy and Safety of Solifenacin Succinate for Urinary Difficulty in Brain Lesion: Multicenter Prospective Study

Bok SK, Lim JH, Cho KH, Choi ES, Kim SS, Lee YJ, Park NK

OBJECTIVE: We studied the efficacy and safety of solifenacin for urinary difficulty in brain lesion from multicenter prospective study. METHOD: Eighty patients with brain lesion who visited from 5 multicenter department...
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Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of In Vivo Drug-Receptor Binding

Yamada S, Kuraoka S, Osano A, Ito Y

  • KMID: 2232961
  • Int Neurourol J.
  • 2012 Sep;16(3):107-115.
The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed. Transdermal administration of oxybutynin...
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Seizure developed after palonosetron intravenous injection during recovery from general anesthesia: A case report

Park PG, Shin HY, Kang H, Jung YH, Woo YC, Kim JY, Koo GH, Park SG, Baek CW

Seizure associated with antiemetics is rare. We report seizure associated with a 5-HT3 receptor antagonist in a 38 years old female. The patient underwent ureterorenoscopic lithotripsy due to left upper...
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Efficacy of Solifenacin on Irritable Bowel Syndrome With Diarrhea: Open-label Prospective Pilot Trial

Fukushima , Suzuki H, Matsuzaki , Kiyosue A, Hibi T

  • KMID: 2325931
  • J Neurogastroenterol Motil.
  • 2012 Jul;18(3):317-323.
BACKGROUND/AIMS: Solifenacin, a muscarinic type 3 receptor antagonist, is used to treat overactive bladder in adults. The aim of this study is to examine the efficacy of solifenacin on the...
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Are Solifenacin and Ramosetron Really Ideal to Treat Irritable Bowel Syndrome?: Author's Reply

Suzuki H, Matsuzaki

  • KMID: 2325961
  • J Neurogastroenterol Motil.
  • 2012 Oct;18(4):459-459.
No abstract available.
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Are Solifenacin and Ramosetron Really Ideal to Treat Irritable Bowel Syndrome?

Chang FY

  • KMID: 2325960
  • J Neurogastroenterol Motil.
  • 2012 Oct;18(4):457-458.
No abstract available.
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The comparative study to evaluate the effect of palonosetron monotherapy versus palonosetron with dexamethasone combination therapy for prevention of postoperative nausea and vomiting

Park JW, Jun JW, Lim YH, Lee SS, Yoo BH, Kim KM, Yon JH, Hong KH

BACKGROUND: 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are effective and safe on postoperative nausea and vomiting (PONV). Palonosetron, the newest 5-HT3 antagonist, has potent antiemetic property. We hypothesized that a...
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Comparison of palonosetron with ondansetron in preventing postoperative nausea and vomiting after thyroidectomy during a 48-hour period

Kim YY, Song DU, Lee KH, Lee IJ, Song JW, Lim JH

  • KMID: 1742020
  • Anesth Pain Med.
  • 2012 Oct;7(4):312-316.
BACKGROUND: Postoperative nausea and vomiting (PONV) are common complications after general anesthesia. This study compared the effects of palonosetron and ondansetron in preventing PONV in patients undergoing thyroidectomy. METHODS: 100 non-smoking...
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Efficacy of Anticholinergics for Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Young and Middle-Aged Patients: A Single-Blinded, Prospective, Multi-Center Study

Kim DS, Kyung YS, Woo SH, Chang YS, Kim HJ

  • KMID: 2232813
  • Int Neurourol J.
  • 2011 Sep;15(3):172-175.
PURPOSE: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) exhibits variable lower urinary tract symptoms (LUTS). The aim of this study was to evaluate the incidence of LUTS and the efficacy of...
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Effects of Tamsulosin, Solifenacin, and Combination Therapy for the Treatment of Ureteral Stent Related Discomforts

Lim KT, Kim YT, Lee TY, Park SY

  • KMID: 2315443
  • Korean J Urol.
  • 2011 Jul;52(7):485-488.
PURPOSE: To evaluate the effect of tamsulosin, solifenacin, and combination therapy of two agents in improving the lower urinary tract symptoms of patients with indwelling double-J ureteral stents. MATERIALS AND METHODS:...
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Effect of Desmopressin with Anticholinergics in Female Patients with Overactive Bladder

Han YK, Lee WK, Lee SH, Yang DY, Kim H

  • KMID: 2315483
  • Korean J Urol.
  • 2011 Jun;52(6):396-400.
PURPOSE: The aim of this study was to evaluate the effect of desmopressin combined with anticholinergics on daytime frequency and urgency in female patients with overactive bladder (OAB). MATERIALS AND METHODS:...
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