- Quercetin ameliorates glutamate toxicity-induced neuronal cell death by controlling calcium-binding protein parvalbumin
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Kang JB, Kang JB, Park DJ, Shah MA, Koh PO
- KMID: 2527878
- J Vet Sci.
- 2022 Mar;23(2):e26.
- doi: 10.4142/jvs.21273
Background: Glutamate is the main excitatory neurotransmitter. Excessive glutamate causes excitatory toxicity and increases intracellular calcium, leading to neuronal death. Parvalbumin is a calcium-binding protein that regulates calcium homeostasis. Quercetin... -
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- Effects of quercetin on the improvement of lipid metabolism through regulating hepatic AMPK and microRNA-21 in high cholesterol diet-fed mice
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Lee MS, Kim Y
- KMID: 2526923
- J Nutr Health.
- 2022 Feb;55(1):36-46.
- doi: 10.4163/jnh.2022.55.1.36
Purpose: Quercetin is a polyphenolic flavonoid abundant in many fruits and vegetables. It has potential health-beneficial properties, such as antioxidant, anti-obesity, anti-cancer, anti-diabetic and anti-inflammatory effects. The purpose of this... -
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- Effects of quercetin on cell differentiation and adipogenesis in 3T3-L1 adipocytes
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Hong SY, Ha AW, Kim W
- KMID: 2518753
- Nutr Res Pract.
- 2021 Aug;15(4):444-455.
- doi: 10.4162/nrp.2021.15.4.444
BACKGROUND/OBJECTIVES: Adipocytes undergo angiogenesis to receive nutrients and oxygen needed for adipocyte' growth and differentiation. No study relating quercetin with angiogenesis in adipocytes exists. Therefore, this study investigated the role... -
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- Quercetin attenuates the reduction of parvalbumin in middle cerebral artery occlusion animal model
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Park DJ, Kang JB, Shah FA, Koh PO
- KMID: 2514399
- Lab Anim Res.
- 2021 Mar;37(1):74-81.
- doi: 10.1186/s42826-021-00086-0
Background: Calcium is a critical factor involved in modulation of essential cellular functions. Parvalbumin is a calcium buffering protein that regulates intracellular calcium concentrations. It prevents rises in calcium concentrations... -
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- Effects of Quercetin Supplementation on Hematological Parameters in Non-Alcoholic Fatty Liver Disease: a Randomized, Double-Blind, Placebo-Controlled Pilot Study
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Pasdar Y, Oubari F, Zarif MN, Abbasi M, Pourmahmoudi A, Hosseinikia M
- KMID: 2468660
- Clin Nutr Res.
- 2020 Jan;9(1):11-19.
- doi: 10.7762/cnr.2020.9.1.11
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease which has become a public health concern. Since oxidative stress plays a crucial role in the pathogenesis of NAFLD,... -
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- Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
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Kim SG, Sung JY, Kim JR, Choi HC
- KMID: 2466571
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):69-79.
- doi: 10.4196/kjpp.2020.24.1.69
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance... -
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- Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner
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Wijerathne TD, Kim JH, Kim MJ, Kim CY, Chae MR, Lee SW, Lee KP
- KMID: 2455814
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):381-392.
- doi: 10.4196/kjpp.2019.23.5.381
Sperm function and male fertility are closely related to pH dependent K⺠current (KSper) in human sperm, which is most likely composed of Slo3 and its auxiliary subunit leucine-rich repeat-containing... -
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- Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice
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Liu H, Lee JI, Ahn TG
- KMID: 2451653
- Obstet Gynecol Sci.
- 2019 Jul;62(4):242-248.
- doi: 10.5468/ogs.2019.62.4.242
OBJECTIVE: The purpose of this study was to determine the effect of quercetin on the antitumor activity of cisplatin and its side-effects. METHODS: EMT6 cells, a mouse breast cancer cell line,... -
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- Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
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Ali A, Kim MJ, Kim MY, Lee HJ, Roh GS, Kim HJ, Cho GJ, Choi WS
- KMID: 2430195
- Anat Cell Biol.
- 2018 Dec;51(4):274-283.
- doi: 10.5115/acb.2018.51.4.274
Hyper-O-GlcNAcylation is a general feature of cancer which contributes to various cancer phenotypes, including cell proliferation and cell growth. Quercetin, a naturally occurring dietary flavonoid, has been reported to reduce... -
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- Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation
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Choi H, Kim CS, Yu R
- KMID: 2415627
- J Obes Metab Syndr.
- 2018 Jun;27(2):102-109.
- doi: 10.7570/jomes.2018.27.2.102
BACKGROUND: Uncoupling protein 1 (UCP1) plays an important role in increasing energy expenditure; thus, it is being considered as a new target for preventing obesity and metabolic complications. In this... -
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- Anti-Diabetic Effect of Cotreatment with Quercetin and Resveratrol in Streptozotocin-Induced Diabetic Rats
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Yang DK, Kang HS
- KMID: 2429052
- Biomol Ther.
- 2018 Mar;26(2):130-138.
- doi: 10.4062/biomolther.2017.254
Quercetin and resveratrol are known to have beneficial effects on the diabetes and diabetic complication, however, the effects of combined treatment of these compounds on diabetes are not fully revealed.... -
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- Quercetin attenuates the injury-induced reduction of γ-enolase expression in a middle cerebral artery occlusion animal model
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Jeon SJ, Kim MO, Ali-Shah F, Koh PO
- KMID: 2402267
- Lab Anim Res.
- 2017 Dec;33(4):308-314.
- doi: 10.5625/lar.2017.33.4.308
Quercetin, a natural flavonoid, copiously exists in vegetable, fruits and tea. Quercetin is beneficial to neurodegenerative disorders via its strong anti-oxidant and anti-inflammatory activities. γ-Enolase is one of the enzymes... -
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- Comparative Effects of Dietary Quercetin and Rutin in Rats Fed with the Lieber-DeCarli Ethanol Diet
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Seo SJ, Park CH, Ko IY, Jeong YH, Choi YS
- KMID: 2393805
- Nat Prod Sci.
- 2017 Sep;23(3):222-226.
- doi: 10.20307/nps.2017.23.3.222
Flavonoids including quercetin and rutin are a group of naturally occurring compounds widely distributed in plants, especially in buckwheat. Thus, cereal and the leaf of the plant have increasingly used... -
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- Quercetin Relaxed the Smooth Muscle of Rabbit Penile Corpus Cavernosum by Activating the NO-cGMP Signaling Pathway
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Choi BR, Kim HK, Park JK
- KMID: 2393797
- Nat Prod Sci.
- 2017 Sep;23(3):169-174.
- doi: 10.20307/nps.2017.23.3.169
The aim of this study was to investigate the effect and action mechanism of quercetin on penile corpus cavernosum smooth muscle (PCCSM). PCCSM precontracted with phenylephrine (Phe) was treated with... -
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- Effects of Quercetin and Mannitol on Erythropoietin Levels in Rats Following Acute Severe Traumatic Brain Injury
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Kalemci O, Aydin HE, Kizmazoglu C, Kaya I, Yılmaz H, Arda NM
- KMID: 2382771
- J Korean Neurosurg Soc.
- 2017 May;60(3):355-361.
- doi: 10.3340/jkns.2016.0505.015
OBJECTIVE: The aim of this study to investigate the normal values of erythropoietin (EPO) and neuroprotective effects of quercetin and mannitol on EPO and hematocrit levels after acute severe traumatic... -
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- Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
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Nguyen LT, Lee YH, Sharma AR, Park JB, Jagga S, Sharma G, Lee SS, Nam JS
- KMID: 2371039
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):205-213.
- doi: 10.4196/kjpp.2017.21.2.205
Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin... -
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- Induction of heme oxygenase-1 with dietary quercetin reduces obesity-induced hepatic inflammation through macrophage phenotype switching
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Kim CS, Choi HS, Joe Y, Chung HT, Yu R
- KMID: 2359619
- Nutr Res Pract.
- 2016 Dec;10(6):623-628.
- doi: 10.4162/nrp.2016.10.6.623
BACKGROUND/OBJECTIVES: Obesity-induced steatohepatitis accompanied by activated hepatic macrophages/Kupffer cells facilitates the progression of hepatic fibrinogenesis and exacerbates metabolic derangements such as insulin resistance. Heme oxyganase-1 (HO-1) modulates tissue macrophage phenotypes... -
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- Quercetin-3-O-β-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells
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Park JY, Lim MS, Kim SI, Lee HJ, Kim SS, Kwon YS, Chun W
- KMID: 2374615
- Biomol Ther.
- 2016 Nov;24(6):610-615.
- doi: 10.4062/biomolther.2016.026
Quercetin, a flavonol, has been reported to exhibit a wide range of biological properties including anti-oxidant and anti-inflammatory activities. However, pharmacological properties of quercetin-3-O-β-D-glucuronide (QG), a glycoside derivative of quercetin,... -
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- The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women
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Kim KA, Yim JE
- KMID: 2355298
- Clin Nutr Res.
- 2016 Oct;5(4):261-269.
- doi: 10.7762/cnr.2016.5.4.261
Quercetin, found abundantly in onion peel, has been known to have antioxidant and anti-obesity effects and improves endothelial function. The purpose of this study was to evaluate the effects of... -
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- Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents
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Lee BH, Choi SH, Kim HJ, Jung SW, Hwang SH, Pyo MK, Rhim H, Kim HC, Kim HK, Lee SM, Nah SY
- KMID: 2351690
- Biomol Ther.
- 2016 Jul;24(4):410-417.
- doi: 10.4062/biomolther.2015.153
Quercetin is a flavonoid usually found in fruits and vegetables. Aside from its antioxidative effects, quercetin, like other flavonoids, has a various neuropharmacological actions. Quercetin-3-O-rhamnoside (Rham1), quercetin-3-O-rutinoside (Rutin), and quercetin-3-(2(G)-rhamnosylrutinoside... -
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