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A Single Center Experience of Less Invasive Surfactant Administration during 6-Year

Bae E, Shim GH

Objective: The aim of this study was to evaluate the feasibility, efficacy, and safety of less invasive surfactant administration (LISA) in preterm and term infants with respiratory distress syndrome (RDS). Methods:...
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Comparison of Respiratory Outcome between the Surfactant without Endotracheal Tube Intubation and the Intubation-SurfactantExtubation Techniques in Extremely Low Gestational Age Neonates with Respi­ratory Distress Syndrome

Cha T, Jeong J, Lee BS, Kim EAR, Kim KS, Jung E

Objective: The aim of this study was to determine whether there were differences in respiratory out comes of extremely low gestational age neonates according to the surfactant without endotracheal tube...
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History of Pulmonary Surfactant Replacement Therapy for Neonatal Respiratory Distress Syndrome in Korea

Bae CW, Kim CY, Chung SH, Choi YS

Neonatal respiratory distress syndrome (RDS) is a disease that is unique to newborn infants. It is caused by a deficiency of pulmonary surfactant (PS), which is usually ready to be...
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Surfactant preparations for preterm infants with respiratory distress syndrome: past, present, and future

Jeon GW

Following the first successful trial of surfactant replacement therapy for preterm infants with respiratory distress syndrome (RDS) by Fujiwara in 1980, several animal-derived natural surfactants and synthetic surfactants have been...
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Transient intubation for surfactant administration in the treatment of respiratory distress syndrome in extremely premature infants

Koh JW, Kim JW, Chang YP

PURPOSE: To investigate the effectiveness of transient intubation for surfactant administration and extubated to nasal continuous positive pressure (INSURE) for treatment of respiratory distress syndrome (RDS) and to identify the...
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A Combination of Short and Simple Surfactant Protein B and C Analogues as a New Synthetic Surfactant: In Vitro and Animal Experiments

Choi YS, Chung SH, Bae CW

PURPOSE: Pulmonary surfactants for preterm infants contain mostly animal-derived surfactant proteins (SPs), which are essential for lowering surface tension. We prepared artificial pulmonary surfactants using synthetic human SP analogs and...
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The use of artificial pulmonary surfactant in neonatal respiratory distress

Choi YS

Pulmonary surfactant instillation is the treatment of choice in neonatal respiratory distress syndrome. The development of artificial surfactant has three decades of history. Animal-derived artificial surfactant is used in most...
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Efficacy of Surfactant-TA, Calfactant and Poractant Alfa for Preterm Infants with Respiratory Distress Syndrome: A Retrospective Study

Jeon GW, Oh M, Sin JB

PURPOSE: To compare the efficacy of the new drug calfactant with the commonly used drugs surfactant-TA and poractant alfa. MATERIALS AND METHODS: A total of 332 preterm infants at 24-31 weeks'...
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Exogenous Surfactant Therapy in Neonates with Respiratory Failure Due to Pulmonary Hemorrhage

Choi HJ, Sin YH, Kim SM

  • KMID: 2280840
  • Korean J Perinatol.
  • 2011 Dec;22(4):319-328.
PURPOSE: The study assessed the effect of exogenous surfactant on oxygen and ventilator requirements and long-term prognosis of neonates with respiratory deterioration due to pulmonary hemorrhage. METHODS: From March 2007 to...
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Surfactant Therapy for Neonatal Respiratory Distress Syndrome: A Review of Korean Experiences over 17 Years

Bae CW, Hahn WH

We undertook a multi-hospital collective study to evaluate outcomes of neonatal respiratory distress syndrome (RDS) patients treated with pulmonary surfactant (PS) over 17 yr in Korea (Group I; 1990/91, Group...
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Comparison of Clinical Efficacy of Newfactan(R) versus Surfacten(R) for the Treatment of Respiratory Distress Syndrome in the Newborn Infants

Choi CW, Hwang JH, Yoo EJ, Kim KA, Koh SY, Lee YK, Shim JW, Lee EK, Chang W, Kim SS, Chang YS, Park WS, Shin SM

Newfactan(R) is a domestically developed, bovine lung-derived, semi-synthetic surfactant. The aim of this study was to compare the clinical efficacy of Newfactan(R) with that of Surfacten(R) in the treatment of...
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Changes in dead space/tidal volume ratio and pulmonary mechanics after surfactant replacement therapy in respiratory distress syndrome of the newborn infants

Chung EH, Ko SY, Kim IY, Chang YS, Park WS

This study was performed to elucidate the mechanism of improved oxygenation after surfactant replacement therapy in respiratory distress syndrome (RDS) of the newborn infants. In 26 newborns with RDS, end...
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Lysis of RBc Membrane and Type II Alveolar Epithelial Cell Toxicity by Various Artificial Pulmonary Surfactants Used in Korea

Park EA, Lee KE, Kim GH

  • KMID: 1566089
  • J Korean Soc Neonatol.
  • 1998 Nov;5(2):151-157.
PURPOSE: Surfactant replacement therapy is now recognized as a life saving and safe intervention in small premature infants with respiratory distress syndrome. The incidence of pulmonary hemorrhage is increased in...
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