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Major Depressive Disorder Preceding the Onset of Progressive Supranuclear Palsy

Kim WH, Lee YS, Jung SH, Choi HJ, Lee MJ, Kang MH, Kim CE, Lee JS, Bae JN

  • Psychiatry Investig.
  • 2009 Jun;6(2):112-114.
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by vertical supranuclear palsy and parkinsonian symptoms. The neuropsychiatric symptoms of PSP include anhedonia, depressed mood and cognitive impairment. Patients with...
No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia

Lee HJ, Kang SG, Choi JE, Park YM, Lim SW, Rhee MK, Kim SH, Kim L

  • Psychiatry Investig.
  • 2009 Jun;6(2):108-111.
OBJECTIVE: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a...
AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia

Joo EJ, Lee KY, Jeong SH, Roh MS, Kim SH, Ahn YM, Kim YS

  • Psychiatry Investig.
  • 2009 Jun;6(2):102-107.
OBJECTIVE: We performed a genetic association study with schizophrenic patients to investigate whether the V-akt murine thymoma viral oncogene homolog 1 (AKT1) gene plays a role in obstetric complications. METHODS:...
Polarity of the First Episode and Time to Diagnosis of Bipolar I Disorder

Cha B, Kim JH, Ha TH, Chang JS, Ha K

  • Psychiatry Investig.
  • 2009 Jun;6(2):96-101.
OBJECTIVE: The current study explored the relationship between the polarity of the first episode and the timing of eventual diagnosis of bipolar I disorder, and associated clinical implications. METHODS: Twelve...
Treatment with Selective Serotonin Reuptake Inhibitors and Mirtapazine Results in Differential Brain Activation by Visual Erotic Stimuli in Patients with Major Depressive Disorder

Kim W, Jin BR, Yang WS, Lee KU, Juh RH, Ahn KJ, Chung YA, Chae JH

  • Psychiatry Investig.
  • 2009 Jun;6(2):85-95.
OBJECTIVE: The objective of this study was to identify patterns of brain activation elicited by erotic visual stimuli in patients treated with either Selective Serotonin Reuptake Inhibitors (SSRIs) or mirtazipine....
Correlates of Metabolic Abnormalities in Bipolar I Disorder at Initiation of Acute Phase Treatment

Kim B, Kim S, McIntyre R, Park HJ, Kim SY, Joo YH

  • Psychiatry Investig.
  • 2009 Jun;6(2):78-84.
OBJECTIVE: Treatment of bipolar patients is often complicated by metabolic abnormalities such as obesity, diabetes, and dyslipidemia. We therefore evaluated the prevalence of these abnormalities and their correlates, in bipolar...
Anhedonia and Ambivalence in Schizophrenic Patients with Fronto-Cerebellar Metabolic Abnormalities: A Fluoro-D-Glucose Positron Emission Tomography Study

Park KM, Kim JJ, Seok JH, Chun JW, Park HJ, Lee JD

  • Psychiatry Investig.
  • 2009 Jun;6(2):72-77.
OBJECTIVE: Prefrontal and cerebellar abnormalities have been associated with higher cognitive deficits in schizophrenia. The current study aimed to show whether or not schizophrenic patients with fronto-cerebellar functional abnormalities show...
Accept or Refuse? A Pilot Study of Patients' Perspective on Participating as Imaginary Research Subjects in Schizophrenia

Kim JH, Kim D, Park SH, Nam J

  • Psychiatry Investig.
  • 2009 Jun;6(2):66-71.
OBJECTIVE: The goal of the present study was to evaluate demographic and clinical factors that affect the intention to participate in commonly-conducted research in patients with schizophrenia. METHODS: Thirty-four outpatients...
Service Priority and Standard Performance of Community Mental Health Centers in South Korea: A Delphi Approach

Lee MS, Hoe M, Hwang TY, Lee YM

  • Psychiatry Investig.
  • 2009 Jun;6(2):59-65.
OBJECTIVE: The role of community mental health centers (CMHCs) in Korea is quite different than that of these centers in Western countries due to nation-specific health care system characteristics. For...
Does Pregabalin Have Neuropsychotropic Effects?: A Short Perspective

Marks DM, Patkar AA, Masand PS, Pae CU

  • Psychiatry Investig.
  • 2009 Jun;6(2):55-58.
Pregabalin is a newly developed synthetic gamma-aminobutyric acid (GABA) that is approved for the treatment of fibromyalgia and several neuropathy. It has been proven to show analgesic, anxiolytic, anticonvulsant and...

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