- Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis
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Yin H, Wang S, Gu C
- KMID: 2471339
- Ann Dermatol.
- 2020 Apr;32(2):130-140.
- doi: 10.5021/ad.2020.32.2.130
BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals. OBJECTIVE: Since the limitation of dataset associated with human severe AD,... -
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- Cutaneous Angiosarcoma of the Foot Accompanied by Multiple Myeloma: The First Case Report
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Jo JW, Shin YB, Kwon CI, Kim CY
- KMID: 2457693
- Korean J Dermatol.
- 2019 Aug;57(7):399-402.
Although the exact etiology of cutaneous angiosarcoma remains unclear, MYC gene amplification has been recently discovered as a new pathogenesis. MYC is a proto-oncogene, and aberration of MYC signaling in... -
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- Prominent Inflammatory Features of Monocytes/Macrophages in Acute Calcium Pyrophosphate Crystal Arthritis: a Comparison with Acute Gouty Arthritis
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Jeong JH, Jung JH, Lee JS, Oh JS, Kim YG, Lee CK, Yoo B, Hong S
- KMID: 2450206
- Immune Netw.
- 2019 Jun;19(3):e21.
- doi: 10.4110/in.2019.19.e21
Calcium pyrophosphate (CPP) crystals can present as acute inflammatory arthritis which is known as an acute CPP crystal arthritis. Although monocytes/macrophages have been shown to play a role in the... -
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- Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1
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Chen L, Zhong J, Liu JH, Liao DF, Shen YY, Zhong XL, Xiao X, Ding WJ, Peng XD, Xiong W, Zu XY
- KMID: 2441848
- J Breast Cancer.
- 2019 Mar;22(1):15-28.
- doi: 10.4048/jbc.2019.22.e11
PURPOSE: Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study... -
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- Mouse Models as a Tool for Understanding Progression in Braf(V600E)-Driven Thyroid Cancers
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Landa I, Knauf JA
- KMID: 2441674
- Endocrinol Metab.
- 2019 Mar;34(1):11-22.
- doi: 10.3803/EnM.2019.34.1.11
The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have... -
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- Convergence of Cancer Metabolism and Immunity: an Overview
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Van Dang C, Kim JW
- KMID: 2400809
- Biomol Ther.
- 2018 Jan;26(1):4-9.
- doi: 10.4062/biomolther.2017.194
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence... -
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- GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers
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Park YR, Bae SH, Ji W, Seo EJ, Lee JC, Kim HR, Jang SJ, Choi CM
- KMID: 2390304
- J Korean Med Sci.
- 2017 Nov;32(11):1784-1791.
- doi: 10.3346/jkms.2017.32.11.1784
Lung squamous cell cancer (SCC) is typically found in smokers and has a very low incidence in non-smokers, indicating differences in the tumor biology of lung SCC in smokers and... -
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- Comparison of Changes in the Interstitial Cells of Cajal and Neuronal Nitric Oxide Synthase-positive Neuronal Cells With Aging Between the Ascending and Descending Colon of F344 Rats
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Lee SM, Kim N, Jo HJ, Park JH, Nam RH, Lee HS, Kim HJ, Lee MY, Kim YS, Lee DH
- KMID: 2395429
- J Neurogastroenterol Motil.
- 2017 Oct;23(4):592-605.
- doi: 10.5056/jnm17061
BACKGROUND/AIMS: Neuronal degeneration and changes in interstitial cells of Cajal (ICCs) are important mechanisms of age-related constipation. This study aims to compare the distribution of ICCs and neuronal nitric oxide... -
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- Effect of ionizing radiation at low dose on transgenerational carcinogenesis by epigenetic regulation
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Li L, Kim JH, Park HT, Lee JH, Park MK, Lee JW, Lee JC, Lee MJ
- KMID: 2407421
- Lab Anim Res.
- 2017 Jun;33(2):92-97.
- doi: 10.5625/lar.2017.33.2.92
The objective of this study was to determine the effect of ionizing radiation (IR) exposure of parents on carcinogenesis of the next generation focusing on the epigenetic perspective to clarify... -
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- Pheochromocytoma Developed in a Boy with Multiple Endocrine Neoplasia Type 2A Confirmed by the RET Proto-Oncogene Mutation
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Park SY, Jin MJ, Choi EM, Kang SJ, Choi JH, Shim YJ, Kim HS, Jung EY, Lee HJ, Choi MS, Kim HW
- KMID: 2379354
- Clin Pediatr Hematol Oncol.
- 2017 Apr;24(1):75-79.
- doi: 10.15264/cpho.2017.24.1.75
A 9-year-old boy presented with increased sweating and abdominal pain. His mother and uncle had been diagnosed with bilateral pheochromocytoma and medullary thyroid carcinoma. Magnetic resonance imaging of the boy's... -
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- Inhibition of c-Yes Induces Differentiation of HT-29 Human Colon Cancer Stem Cells through Midbody Elongation
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Jung J, Choi SC, Lee HN, Han GY, Kim CW
- KMID: 2361010
- Tissue Eng Regen Med.
- 2016 Jun;13(3):261-269.
- doi: 10.1007/s13770-016-9053-x
Recent research suggests that a small group of cells, named cancer stem cells (CSCs), is responsible for initiating tumor formation, recurrence, and metastasis. c-Yes, a proto-oncogene that is a subfamily... -
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- VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma
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Park S, Nam SJ, Keam B, Kim TM, Jeon YK, Lee SH, Hah JH, Kwon TK, Kim DW, Sung MW, Heo DS, Bang YJ
- KMID: 2454328
- Cancer Res Treat.
- 2016 Apr;48(2):518-526.
- doi: 10.4143/crt.2015.093
PURPOSE: The purpose of this study was to evaluate potential prognostic factors in patients with adenoid cystic carcinoma (ACC). MATERIALS AND METHODS: A total of 68 patients who underwent curative surgery... -
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- Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo
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Starenki D, Park JI
- KMID: 2169670
- Endocrinol Metab.
- 2015 Dec;30(4):593-603.
- doi: 10.3803/EnM.2015.30.4.593
BACKGROUND: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the rearranged during transfection (RET) proto-oncogene. Not all patients with progressive MTC respond to current therapy... -
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- Mutation Profile of Well-Differentiated Thyroid Cancer in Asians
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Song YS, Lim JA, Park YJ
- KMID: 2407074
- Endocrinol Metab.
- 2015 Sep;30(3):252-262.
- doi: 10.3803/EnM.2015.30.3.252
Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated... -
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- The Frequency and Clinical Implications of the BRAF(V600E) Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two Decades
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Hong AR, Lim JA, Kim TH, Choi HS, Yoo WS, Min HS, Won JK, Lee KE, Jung KC, Park DJ, Park YJ
- KMID: 2384248
- Endocrinol Metab.
- 2014 Dec;29(4):505-513.
- doi: 10.3803/EnM.2014.29.4.505
BACKGROUND: Over the past several decades, there has been a rapid worldwide increase in the prevalence of papillary thyroid cancer (PTC) as well as a number of changes in the... -
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- Two Cases of Multiple Endocrine Neoplasia Type II with RET Mutaion
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Yoo SY, Choi YH, Lee MK, Kim MS, Hwang PH
- KMID: 2279829
- Clin Pediatr Hematol Oncol.
- 2014 Oct;21(2):163-167.
- doi: 10.0000/cpho.2014.21.2.163
Multiple endocrine neoplasia type 2(MEN2) is a rare autosomal dominant inherited disorder characterized by the presence of medullary thyroid carcinoma, pheochromocytoma and other hyperplasia and/or neoplasia of different endocrine tissues... -
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- Molecular Pathogenesis and Targeted Therapies in Well-Differentiated Thyroid Carcinoma
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Kim JG
- KMID: 2169455
- Endocrinol Metab.
- 2014 Sep;29(3):211-216.
- doi: 10.3803/EnM.2014.29.3.211
Four proto-oncogenes commonly associated with well-differentiated thyroid carcinoma, rearranged during transfection (RET)/papillary thyroid cancer, BRAF, RAS, and PAX8/peroxisome proliferator activated receptor-gamma, may carry diagnostic and prognostic significance. These oncogenes can... -
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- Spinal Cord Ependymoma Associated with Neurofibromatosis 1 : Case Report and Review of the Literature
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Cheng H, Shan M, Feng C, Wang X
- KMID: 2191040
- J Korean Neurosurg Soc.
- 2014 Jan;55(1):43-47.
- doi: 10.3340/jkns.2014.55.1.43
Patients with neurofibromatosis 1 (NF1) are predisposed to develop central nervous system tumors, due to the loss of neurofibromin, an inactivator of proto-oncogene Ras. However, to our knowledge, only three... -
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- Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence
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Yun DK, Lee J, Keum YS
- KMID: 2170685
- Biomol Ther.
- 2013 Jan;21(1):49-53.
A number of naturally-occurring or synthetic chemicals have been reported to exhibit prostate chemopreventive effects. Synthetic 5alpha-reductase (5-AR) inhibitors, e.g. finasteride and durasteride, gained special interests as possible prostate chemopreventive... -
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- Multiple Endocrine Neoplasia and Familial Medullary Thyroid Carcinoma
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Choi YS
- KMID: 2095101
- J Korean Thyroid Assoc.
- 2012 Nov;5(2):124-131.
- doi: 10.11106/jkta.2012.5.2.124
Multiple endocrine neoplasia (MEN) is defined as a disorder with neoplasms in two or more different hormonal tissues in several members of a family. MEN1, or Wermer's syndrome, is inherited... -
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