- Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression
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Yang SY, Nguyen TT, Ung TT, Jung YD
- KMID: 2390431
- Chonnam Med J.
- 2017 Sep;53(3):178-186.
- doi: 10.4068/cmj.2017.53.3.178
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase belonging to the subfamily of which c-MET is the prototype. Large epidemiologic studies have confirmed the strong association between RON and... -
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- Expression of c-Met Is Different along the Location and Associated with Lymph Node Metastasis of Head and Neck Carcinoma
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Choe JY, Yun JY, Nam SJ, Kim JE
- KMID: 2012050
- Korean J Pathol.
- 2012 Dec;46(6):515-522.
BACKGROUND: Activation of the c-Met pathway is involved in cancer progression and the prognosis. We aimed to identify any association of c-Met protein expression with a number of clinicopathologic variables... -
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- Expression of c-MET in Invasive Meningioma
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Yun S, Koh JM, Lee KS, Seo AN, Nam KH, Choe G
- KMID: 2381352
- J Pathol Transl Med.
- 2015 Jan;49(1):44-51.
- doi: 10.4132/jptm.2014.10.13
BACKGROUND: Meningiomas show high recurrence rates even after curative tumor removal. The invasiveness of meningiomas may contribute to their high recurrence rates. Recently, c-MET and hepatocyte growth factor (HGF) have... -
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- Expression of the c-Met Proteins in Malignant Skin Cancers
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Lee YJ, Kim DH, Lee SH, Kim DW, Nam HS, Cho MK
- KMID: 2171949
- Ann Dermatol.
- 2011 Feb;23(1):33-38.
- doi: 10.5021/ad.2011.23.1.33
BACKGROUND: The expression of c-Met is substantially elevated in most malignant human cancers. We therefore searched for c-Met expression and compared the expression level among malignant skin cancers. OBJECTIVE: The aim... -
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- Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas
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Kim NR, Chae YS, Lim WJ, Cho SJ
- KMID: 1443695
- Korean J Pathol.
- 2011 Oct;45(5):463-468.
- doi: 10.4132/KoreanJPathol.2011.45.5.463
BACKGROUND: Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the... -
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- An alternatively spliced form of Met receptor is tumorigenic
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Lee JH, Gao CF, Lee CC, Kim MD, Vande Woude GF
- KMID: 1098091
- Exp Mol Med.
- 2006 Oct;38(5):565-573.
The Met tyrosine kinase receptor is a widely expressed molecule, which mediates pleiotropic cellular responses following activation by its ligand, hepatocyte growth factor/scatter factor (HGF/SF). Previously, one of the authors... -
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- Expression of the c-Met, p53 and Ki-67 Proteins in Astrocytic Tumors
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Cho BH, Cho BM, Ahn HK, Lim WJ, Park SH, Oh SM
- KMID: 1955777
- J Korean Neurosurg Soc.
- 2003 Sep;34(3):202-206.
OBJECTIVE: The pathologic diagnosis of the astrocytoma has been primarily based on the histologic grading, however, there are some discrepancies among the pathologists on the tumor grading. Met protein, known... -
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- A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met
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Chaudhary , Cho MG, Nguyen TT, Park KS, Kwon MH, Lee JH
- KMID: 2155384
- Exp Mol Med.
- 2014 Oct;46(10):e119.
- doi: 10.1038/emm.2014.67
The C-terminal fragment of the c-Met receptor tyrosine kinase is present in the nuclei of some cells irrespective of ligand stimulation, but the responsible nuclear localization signal (NLS) has not... -
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- Study of the Expression of E-cadherin, beta-catenin, and c-Met in Gastric Adenocarcinomas
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Cho SJ, Kim MK, Shin BK, Min YK, Cho MY, Suh SO, Won NH, Chae YS
- KMID: 2372348
- J Korean Gastric Cancer Assoc.
- 2001 Jun;1(2):92-99.
PURPOSE: E-cadherin is an adhesion molecule essential for tight connection between cells, forming the cadherin/catenin complex. Truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin, leading to the loss of... -
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- Expression of c-met Gene in Thyroid Tumors
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Cha HJ, Cho SJ, Yoo CW, Chang WY, Kang HJ, Joo SH, Park CH, Park CJ
- KMID: 1896216
- J Korean Surg Soc.
- 2004 Oct;67(4):279-285.
PURPOSE: The hepatocyte growth factor, (HGF)/c-Met, pathway may play various roles in the carcinogenesis of various organs. HGF, a ligand for c-Met, is a pleiotrophic factor that was originally identified... -
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- Expression of c-erbB-2 and c-met Proteins in Gastric Adenoma and Adenocarcinoma
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Lee SW, Kang SB, Kim YS, Nam SW, Lee DS, Lee HK, Han SW
- KMID: 782837
- Korean J Gastroenterol.
- 2007 Mar;49(3):152-157.
BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical overexpression of c-erbB-2 and c-met proteins according to the histopathological parameters such as grade of dysplasia, histological type, depth... -
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- Epigallocatechin-3-gallate inhibits paracrine and autocrine hepatocyte growth factor/scatter factor-induced tumor cell migration and invasion
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Kwak IH, Shin YH, Kim M, Cha HY, Nam HJ, Lee BS, Chaudhary , Pai KS, Lee JH
- KMID: 1097268
- Exp Mol Med.
- 2011 Feb;43(2):111-120.
- doi: 10.3858/emm.2011.43.2.013
Aberrant activation of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, Met, is involved in the development and progression of many human cancers. In the cell-based screening assay, (-)epigallocatechin-3-gallate (EGCG)... -
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- Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line
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Lee YY, Kim HP, Kang MJ, Cho BK, Han SW, Kim TY, Yi EC
- KMID: 2154283
- Exp Mol Med.
- 2013 Nov;45(11):e64.
Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases, has shown promising results as a growth inhibitor of HER2-positive... -
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- Hepatocyte Growth Factor and Kidney Disease
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Park JS, Kim GH
- KMID: 2252674
- Korean J Nephrol.
- 2011 Jul;30(4):359-367.
Hepatocyte growth factor (HGF), also known as scatter factor, was identified during the experimental attempts to explore a phantom factor acting as a trigger for liver regeneration after partial hepatecotmy.... -
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- Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma
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Kang GH, Lee BS, Lee ES, Kim SH, Lee HY, Kang DY
- KMID: 1774532
- Gut Liver.
- 2014 Jan;8(1):79-87.
BACKGROUND/AIMS: The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival. METHODS: We... -
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- Potential Antitumor Activity of SIM-89 in Non-Small Cell Lung Cancer Cells
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Pei J, Chu T, Shao M, Teng J, Sha H, Gu A, Li R, Qian J, Mao W, Li Y, Han B
- KMID: 2419116
- Yonsei Med J.
- 2017 May;58(3):581-591.
- doi: 10.3349/ymj.2017.58.3.581
PURPOSE: c-Met and its ligand, hepatocyte growth factor (HGF), play a critical role in oncogenesis and metastatic progression. The aim of this study was to identify inhibited enzymogram and to... -
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- Role of HGF/c-Met in Serum-Starved ARPE-19 Cells
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Jun EJ, Kim HS, Kim YH
- KMID: 754644
- Korean J Ophthalmol.
- 2007 Dec;21(4):244-250.
- doi: 10.3341/kjo.2007.21.4.244
PURPOSE: Hepatocyte growth factor (HGF) and its receptor (HGFR/c-Met) regulate motility, mitogenesis, and morphogenesis in a cell type-dependent fashion. We report the role of HGF and c-Met on stress-induced... -
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- Expressions and Clinical Significances of c-met, c-erbB-2, COX-2, and IL-6 in the Biliary Tract Cancers
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Joo HH, Song EY, Jin SH, Oh SH, Choi YK
- KMID: 937932
- Korean J Gastroenterol.
- 2007 Dec;50(6):370-378.
BACKGROUND/AIMS: c-met, c-erbB-2, interleukin (IL)-6, and cyclooxygenase (COX)-2 expressions are considered to be implicated in the carcinogenesis and progression of cholangiocarcinoma, but the molecular pathogenesis of cholangiocarcinoma is still... -
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- Dimethylnitrosamine-Induced Liver Cirrhosis and Expression of Hepatocyte Growth Factor (HGF), its Receptor c-Met, and the Transforming Growth Factor (TGF)-beta1 in Sprague-Dawley Rats
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Kim WH, Lee JH, Jin YM, Cho H, Park HL, Jung MK, Kwak YS, Han SU, Wang HJ, Lee KU, Kim MW
- KMID: 2206400
- J Korean Surg Soc.
- 1998 Oct;55(4):453-468.
BACKGROUND: Liver fibrosis and cirrhosis are the ultimate histologic consequences of chronic liver damage. Efforts have been made to study the mechanisms of cirrhosis and to discover effective therapeutic strategies.... -
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- Hepatocyte Growth Factor/c-Met Signaling in Regulating Urokinase Plasminogen Activator in Human Stomach Cancer: A Potential Therapeutic Target for Human Stomach Cancer
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Lee KH, Choi EY, Hyun MS, Jang BI, Kim TN, Kim SW, Song SK, Kim JH, Kim JR
- KMID: 1782247
- Korean J Intern Med.
- 2006 Mar;21(1):20-27.
- doi: 10.3904/kjim.2006.21.1.20
BACKGROUND: Up-regulation of the hepatocyte growth factor (HGF), its transmembrane tyrosine kinase receptor (c-Met), and urokinase type plasminogen activator (uPA), is associated with the development and metastasis of various... -
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