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Sarcopenia: Ammonia metabolism and hepatic encephalopathy

Jindal A, Jagdish RK

Sarcopenia (loss of muscle mass and/or strength) frequently complicates liver cirrhosis and adversely affects the quality of life; cirrhosis related liver decompensation and significantly decreases wait-list and post-liver transplantation survival....
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Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats

Kang JB, Park DJ, Koh PO

Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal cerebral...
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Chemical Regeneration of Wound Defects: Relevance to the Canine Palatal Mucosa and Cell Cycle Up-Regulation in Human Gingival Fibroblasts

Lee K, Ben Amara , Lee SC, Leesungbok R, Chung MA, Koo KT, Lee SW

BACKGROUND: Trichloroacetic acid (TCA) is an agent widely applied in dermatology for skin regeneration. To test whether TCA can offer an advantage for the regeneration of oral soft tissue defects,...
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Associations of Ubiquitin-Specific Protease Genes with Resilience and Social Anxiety in Healthy Youths

Seo JH, Park CI, Kim SJ, Kang JI

OBJECTIVE: Dynamic proteolysis, through the ubiquitin-proteasome system, is an important molecular mechanism for the constant regulation of synaptic plasticity and stress responses in humans. In this study, we examined whether...
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Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3

Lee K, Kim H, Lee J, Oh CM, Song H, Kim H, Koo SH, Lee J, Lim A, Kim H

BACKGROUND: Protein arginine methyltransferase 1 (PRMT1) is a major enzyme responsible for the formation of methylarginine in mammalian cells. Recent studies have revealed that PRMT1 plays important roles in the...
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Regulation of Protein Degradation by Proteasomes in Cancer

Jang HH

Imbalance of protein homeostasis (proteostasis) is known to cause cellular malfunction, cell death, and diseases. Elaborate regulation of protein synthesis and degradation is one of the important processes in maintaining...
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Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1

Song Y, Lee S, Kim JR, Jho EH

Ubiquitination of proteins plays an essential role in various cellular processes, including protein degradation, DNA repair, and cell signaling pathways. Previous studies have shown that protein ubiquitination is implicated in...
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Effects of a Proteasome Inhibitor on Cardiomyocytes in a Pressure-Overload Hypertrophy Rat Model: An Animal Study

Kim IS, Jo WM

BACKGROUND: The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the...
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Kainic Acid Treatment Increases Ca²⁺-mediated Neurotoxicity in the Mouse Hippocampus

Lee JE

Kainic acid (KA)-induced neuronal cell death is associated with intracellular Ca²⁺ influx. However, it is unknown whether Lyn/Btk pathway is involved in the Ca²⁺-mediated neurotoxicity and neuronal death induced by...
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Crystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma

Lee EJ, Lee SY, Park SY, Kim Y, Choi JS, Kim MJ, Park JH, Lee JE, Kwon GY, Kim YG

Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain–secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause...
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Alpha-Ketoglutarate: Physiological Functions and Applications

Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D

Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source...
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Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription

Lee J, Chun SK, Son GH, Kim K

BACKGROUND: Hes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system. Here we...
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Characterization of proteases isolated from Kudoa septempunctata

Shin SP, Zenke K, Yokoyama H

Proteases play important roles in parasite development and host parasite interactions. The protease of Kudoa spp. has been recognized as a key factor of severe proteolysis of fish muscle post-mortem;...
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Metabolic Effects of Growth Hormones in Children

Rhie YJ

  • KMID: 2271160
  • Korean J Obes.
  • 2015 Jun;24(2):87-91.
Ever since recombinant human growth hormones (GH) were produced in the 1980s, many studies on their metabolic effects have been performed. GH has been shown to have a diabetogenic action...
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Polyubiquitin chain-dependent protein degradation in TRIM30 cytoplasmic bodies

Choi UY, Choi WY, Hur JY, Kim YJ

Viral infection induces numerous tripartite motif (TRIM) proteins to control antiviral immune signaling and viral replication. Particularly, SPRY-containing TRIM proteins are found only in vertebrates and they control target protein...
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Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

Ciechanover A, Kwon YT

Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the...
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Nutrition Therapy in Critically Ill Patients

Hong SK

Nutrition therapy is challenging in critically ill patients. Critical illness is associated with a state of catabolic stress, in which stress hormones and inflammatory mediators are activated, resulting in proteolysis....
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beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells

Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I

An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene....
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Phospholipase D2 promotes degradation of hypoxia-inducible factor-1alpha independent of lipase activity

Park MH, Bae SS, Choi KY, Min DS

Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension. The stability of HIF-1alpha protein...
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The usefulness of soluble transferrin receptor in the diagnosis and treatment of iron deficiency anemia in children

Yoon SH, Kim DS, Yu ST, Shin SR, Choi DY

PURPOSE: Soluble transferrin receptor (sTfR) is a truncated extracellular form of the membrane transferrin receptor produced by proteolysis. Concentrations of serum sTfR are related to iron status and erythropoiesis in...
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