- HPV-18 E7 Interacts with Elk-1 Leading to Elevation of the Transcriptional Activity of Elk-1 in Cervical Cancer
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Go SH, Rho SB, Yang DW, Kim BR, Lee CH, Lee SH
- KMID: 2534710
- Biomol Ther.
- 2022 Nov;30(6):593-602.
- doi: 10.4062/biomolther.2022.108
The human papillomavirus (HPV)-18 E7 (E7) oncoprotein is a major transforming protein that is thought to be involved in the development of cervical cancer. It is well-known that E7 stimulates... -
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- The Protein-Protein Interaction Network of Hereditary Parkinsonism Genes Is a Hierarchical Scale-Free Network
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Kim YJ, Kim K, Lee H, Jeon J, Lee J, Yoon J
- KMID: 2531887
- Yonsei Med J.
- 2022 Aug;63(8):724-734.
- doi: 10.3349/ymj.2022.63.8.724
Purpose: Hereditary parkinsonism genes consist of causative genes of familial Parkinson’s disease (PD) with a locus symbol prefix (PARK genes) and hereditary atypical parkinsonian disorders that present atypical features and... -
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- Non-canonical vs. Canonical Functions of Heme Oxygenase-1 in Cancer
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Jagadeesh ASV, Fang X, Kim SH, Guillen-Quispe YN, Zheng J, Surh YJ, Kim SJ
- KMID: 2528081
- J Cancer Prev.
- 2022 Mar;27(1):7-15.
- doi: 10.15430/JCP.2022.27.1.7
Heme oxygenase-1 (HO-1) is a critical stress-responsive enzyme that has antioxidant and anti-inflammatory functions. HO-1 catalyzes heme degradation, which gives rise to the formation of carbon monoxide (CO), biliverdin, and... -
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- Potential biomarkers and signaling pathways associated with the pathogenesis of primary salivary gland carcinoma: a bioinformatics study
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Bayat Z, Ahmadi-Motamayel F, Parsa MS, Taherkhani A
- KMID: 2524333
- Genomics Inform.
- 2021 Dec;19(4):e42.
- doi: 10.5808/gi.21052
Salivary gland carcinoma (SGC) is rare cancer, constituting 6% of neoplasms in the head and neck area. The most responsible genes and pathways involved in the pathology of this disorder... -
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- Association Study of Polymorphisms in Neuronal Nicotinic Acetylcholine Receptor Subunit Genes With Schizophrenia in the Han Chinese Population
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Li Yy, Geng Rj, Yu Sy, Li Gj, Wang Zy, Li Hf
- KMID: 2521655
- Psychiatry Investig.
- 2021 Oct;18(10):943-948.
- doi: 10.30773/pi.2021.0151
Objective To investigate the relation between nicotinic acetylcholine receptor subunit (nAChR) genes and schizophrenia, and the relation between tag single nucleotide polymorphism (rs1317286, rs1044396, rs6494212, rs16969968, and rs684513) and schizophrenia... -
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- Understanding the genetics of systemic lupus erythematosus using Bayesian statistics and gene network analysis
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Nam SW, Lee KS, Yang JW, Ko Y, Eisenhut M, Lee KH, Shin JI, Kronbichler A
- KMID: 2515441
- Clin Exp Pediatr.
- 2021 May;64(5):208-222.
- doi: 10.3345/cep.2020.00633
The publication of genetic epidemiology meta-analyses has increased rapidly, but it has been suggested that many of the statistically significant results are false positive. In addition, most such meta-analyses have... -
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- Prediction of hub genes of Alzheimer’s disease using a protein interaction network and functional enrichment analysis
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Wee JJ, Kumar S
- KMID: 2510354
- Genomics Inform.
- 2020 Dec;18(4):e39.
- doi: 10.5808/GI.2020.18.4.e39
Alzheimer disease (AD) is a chronic, progressive brain disorder that slowly destroys affected individuals’ memory and reasoning faculties, and consequently, their ability to perform the simplest tasks. This study investigated... -
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- Classic Studies on the Interaction of Cocaine and the Dopamine Transporter
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Verma V
- KMID: 2171022
- Clin Psychopharmacol Neurosci.
- 2015 Dec;13(3):227-238.
- doi: 10.9758/cpn.2015.13.3.227
The dopamine transporter is responsible for recycling dopamine after release. Inhibitors of the dopamine transporter, such as cocaine, will stop the reuptake of dopamine and allow it to stay extracellularly,... -
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- In silico Screening of Chemical Libraries to Develop Inhibitors That Hamper the Interaction of PCSK9 with the LDL Receptor
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Min DK, Lee HS, Lee N, Lee CJ, Song HJ, Yang GE, Yoon D, Park SW
- KMID: 2163616
- Yonsei Med J.
- 2015 Sep;56(5):1251-1257.
- doi: 10.3349/ymj.2015.56.5.1251
PURPOSE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) and promotes degradation of the LDLR. Inhibition of PCSK9 either by reducing its expression or... -
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- Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery
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Seo YH
- KMID: 2171313
- J Cancer Prev.
- 2015 Mar;20(1):5-11.
- doi: 10.15430/JCP.2015.20.1.5
Heat shock protein 90 (Hsp90) is an adenosine triphosphate dependent molecular chaperone in eukaryotic cells that regulates the activation and maintenance of numerous regulatory and signaling proteins including epidermal growth... -
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- Review of Biological Network Data and Its Applications
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Yu D, Kim M, Xiao G, Hwang TH
- KMID: 2166503
- Genomics Inform.
- 2013 Dec;11(4):200-210.
- doi: 10.5808/GI.2013.11.4.200
Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA... -
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- A New Approach to Find Orthologous Proteins Using Sequence and Protein-Protein Interaction Similarity
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Kim MK, Seol YJ, Park HS, Jang SH, Shin HC, Cho KH
- KMID: 1469572
- Genomics Inform.
- 2009 Sep;7(3):141-147.
Developed proteome-scale ortholog and paralog prediction methods are mainly based on sequence similarity. However, it is known that even the closest BLAST hit often does not mean the closest neighbor.... -
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- Microarray Data Analysis of Perturbed Pathways in Breast Cancer Tissues
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Kim C, Choi J, Yoon S
- KMID: 2166421
- Genomics Inform.
- 2008 Dec;6(4):210-222.
Due to the polygenic nature of cancer, it is believed that breast cancer is caused by the perturbation of multiple genes and their complex interactions, which contribute to the wide... -
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