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Protein tyrosine phosphatase 1B is a mediator of cyclic ADP ribose-induced Ca²⁺ signaling in ventricular myocytes

Park SA, Hong BZ, Ha KC, Kim UH, Han MK, Kwak YG

Cyclic ADP-ribose (cADPR) releases Ca²⁺ from ryanodine receptor (RyR)-sensitive calcium pools in various cell types. In cardiac myocytes, the physiological levels of cADPR transiently increase the amplitude and frequency of...
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Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation

Song GJ, Kim J, Kim JH, Song S, Park H, Zhang ZY, Suk K

Protein tyrosine phosphatases (PTPs) are key regulatory factors in inflammatory signaling pathways. Although PTPs have been extensively studied, little is known about their role in neuroinflammation. In the present study,...
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STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance

Kim YJ, Kang Y, Park HY, Lee JR, Yu DY, Murata T, Gondo Y, Hwang JH, Kim YH, Lee CH, Rhee M, Han PL, Chung BH, Lee HJ, Kim KS

Striatal-enriched protein tyrosine phosphatase (STEP) is abundantly expressed in the striatum, which strongly expresses dopamine and opioid receptors and mediates the effects of many drugs of abuse. However, little is...
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A single fraction from Uncaria sinensis exerts neuroprotective effects against glutamate-induced neurotoxicity in primary cultured cortical neurons

Kim HN, Jang JY, Choi BT

We identified a neuroprotective single fraction among 62 ones of hexane extract from Uncaria sinensis (JGH43IA) and investigated its effects and mechanisms in primary cortical neurons. Pretreatment with JGH43IA showed...
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Distribution of Serotypes and Antibiotic Susceptibility Patterns Among Invasive Pneumococcal Diseases in Saudi Arabia

A Al-Sherikh Y, K Gowda L, Mohammed Ali MM, John J, Khaled Homoud Mohammed D, Chikkabidare Shashidhar P

BACKGROUND: Streptococcus pneumoniae causes life-threatening infections such as meningitis, pneumonia, and febrile bacteremia, particularly in young children. The increasing number of drug-resistant isolates has highlighted the necessity for intervening and...
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Reactive Oxygen Species and Cellular Function Switch

Ryu SE

Reactive oxygen species (ROS) are harmful to cellular components such as proteins, DNA and lipids. The continuous production of ROS during the respiratory electron transfer process has been regarded as...
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Combined Genome-Wide Linkage and Association Analyses of Fasting Glucose Level in Healthy Twins and Families of Korea

Suh YJ, Kim S, Kim SH, Park J, Lim HA, Park HJ, Choi H, Ng D, Lee MK, Nam M

This study was undertaken to identify genetic polymorphisms that are associated with the risk of an elevated fasting glucose (FG) level using genome-wide analyses. We explored a quantitative trait locus...
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Two Cases of X-Linked Myotubular Myopathy with Novel MTM1 Mutations

Lee EH, Yum MS, Park SJ, Lee BH, Kim GH, Yoo HW, Ko TS

BACKGROUND: Myotubular myopathy (MTM) is a congenital myopathy characterized by centrally placed nuclei in muscle fibers. Mutations in the myotubularin 1 gene (MTM1) have been identified in the most of...
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Correlation between Liver Metastases and the Level of PRL-3 mRNA Expression in Patients with Primary Colorectal Cancer

Kim NW, Chu CW, Ahn TS, Kim CJ, Jung DJ, Son MW, Bae SH, Lee MS, Kim CH, Baek MJ

PURPOSE: Phosphatase of regenerating liver-3 (PRL-3) has been associated with metastasis promotion. However, clinical applications of this association have not yet been clearly demonstrated. In this study, we evaluated the...
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X-linked Myotubular Myopathy in a Family with Two Infant Siblings: A Case with MTM1 Mutation

Jeon JH, Namgung R, Park MS, Park KI, Lee C, Lee JS, Kim SH

X-linked myotubular myopathy (XLMTM) is a rare congenital muscle disorder, caused by mutations in the MTM1 gene. Affected male infants present severe hypotonia, and generalized muscle weakness, and the disorder...
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Characterization of Monoclonal Antibodies against Human Leukocyte Common Antigen (CD45)

Shin HM, Cho WD, Lee GK, Lee SH, Lee KM, Ji GY, Yoon SS, Koo JH, Lee HC, Lee KH, Song HG

BACKGROUND: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. METHODS: We generated seven murine mAbs against human CD45 by injecting cells from different origins,...
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The Role of Oxidative Stress in the Pathogenesis of Asthma

Cho YS, Moon HB

Oxidative stress plays a critical role in the pathogenesis of asthma. To effectively control oxidative stress in asthmatics, it is important to investigate the precise intracellular mechanism by which the...
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Protein Tyrosine Phosphatase N1 Gene Variants Associated with Type 2 Diabetes Mellitus and Its Related Phenotypes in the Korean Population

Hong KW, Jin HS, Lim JE, Ryu HJ, Ahn Y, Lee JY, Han BG, Shin HD, Cho NH, Shin C, Woo JT, Park HK, Oh B

  • KMID: 2166401
  • Genomics Inform.
  • 2008 Sep;6(3):99-109.
Protein phosphorylation at tyrosine residues is a key regulatory event that modulates insulin signal transduction. We studied the PTPN1 gene with regard to susceptibility to Korean type 2 diabetes mellitus (T2DM)...
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Propofol Inhibits Platelet-derived Growth Factor-stimulated Migration in Rat Aortic Smooth Muscle Cells

Lee K, Lee K, Kim B, Lim J, Koo J, Lee M, Lee HM, Lee CK, Won KJ

BACKGROUND: Propofol is the extensively used general anesthetic-sedative agent.Although propofol is known to be involved in migration of various cells, migration response to it in vascular smooth muscle cells is...
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PRL-3 Expression in Primary Colorectal Cancer

Lee HJ, Chu CW, Baek MJ, Shin EJ, Kim HC, Cho GS, Song OP, Kim HK, Park HJ

PURPOSE: Overexpression of the protein tyrosine phosphatase (PRL-3) is elevated in liver metastases derived from colorectal cancer. We examined PRL-3 expression in the primary lesion of colorectal cancer patients and...
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Association of Killer Cell Ig-like Receptor (KIR) with an Adaptor Protein Shc

Cho HI, Chwae YJ, Park SM, Kim J

BACKGROUND: Cytotoxic function of killer cells is inhibited by specific recognition of class I MHC molecules on target cells by inhibitory killer Ig-like receptors (KIR) expressed on NK cells and...
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The long-term effect of ramipril on Gialpha2-protein and Protein Tyrosine Phosphatase 1B in an animal model of type 2 diabetes(OLETF rat)

Lee JM, Hong OK, Kwon HS, Moon SD, Chang SA, Son HS, Yoon KH, Cha BY, Kang SK

  • KMID: 2331782
  • J Korean Diabetes Assoc.
  • 2006 Jan;30(1):25-38.
BACKGROUND: The regulation of tyrosine phosphorylation/dephosphorylation is an important mechanism in various intracellular metabolism. Also impaired insulin signal transduction is important in pathogenesis of type 2 diabetes. It has been...
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Identification of the Marker-Genes for Dioxin(2,3,7,8-tetradibenzo-p-dioxin)-Induced Immune Dysfunction by Using the High-Density Oligonucleotide Microarray

Kim JA, Lee EJ, Kim HL

  • KMID: 2166168
  • Genomics Inform.
  • 2004 Jun;2(2):75-80.
In a variety of animal species, the perinatal exposure of experimental animals to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to the immune dysfunction, which is more severe and persistent than that caused...
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Effect of Orthovanadate on Collagen and Fibronectin Synthesis, and Alkaline Phosphatase Activity in MC3E3-E1 Osteoblast cells

Kim SY, Ihn JC, Choi JY, Ahn JC

  • KMID: 2105968
  • J Korean Orthop Assoc.
  • 2003 Apr;38(2):133-141.
PURPOSE: The purpose: of this study was to know the effect of inhibition of protein dephosphorylation on the synthesis of collagen and fibronectin (FN), alkaline phosphatase (ALP) activity, and the...
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Role of Tyrosine Kinases in Norepinephrine-Induced Vascular Contraction in Renal Hypertensive Rats

Yeum CH, Jun JY, Yoon PJ, Shin MK, Cho HH, Jang JS, Hong SP, Yeum CH

BACKGROUND AND OBJECTIVES: Protein tyrosine kinases appear to be involved in the signal transduction mechanisms, which result in vascular smooth muscle contraction, as well those required in cell growth. The...
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