- The Role of Glomerular Podocytes in Diabetic Nephropathy
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Lee EY, Chung CH
- KMID: 2177557
- J Korean Diabetes Assoc.
- 2007 Nov;31(6):451-454.
- doi: 10.4093/jkda.2007.31.6.451
Diabetic nephropathy is the most common cause of end-stage renal disease and accounts for significant morbidity and mortality among individuals with diabetes mellitus. Therefore, the clarification of the pathogenesis of... -
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- Pathology identifies glomerular treatment targets in diabetic nephropathy
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Alpers CE, Hudkins KL
- KMID: 2416078
- Kidney Res Clin Pract.
- 2018 Jun;37(2):106-111.
- doi: 10.23876/j.krcp.2018.37.2.106
The development of the glomerular injury in diabetic nephropathy involves interactions between podocytes, endothelium, and the mesangium. Loss of podocytes is an early and critical step in the development of... -
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- Pathogenesis of Minimal Change Nephrotic Syndrome: A Review of the Underlying Molecular Mechanisms
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Yang EM
- KMID: 2448156
- Child Kidney Dis.
- 2019 Apr;23(1):1-6.
- doi: 10.3339/jkspn.2019.23.1.1
Nephrotic syndrome (NS) is the most common glomerular disorder in childhood, and a vast majority of cases are idiopathic. The precise cause of this common childhood disease is not fully... -
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- Significance of Osteopontin Expression in the Progression of Human Focal Segmental Glomerulosclerosis
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Yoon GS, Kim TS
- KMID: 2277553
- Korean J Pathol.
- 2010 Oct;44(5):462-468.
BACKGROUND: Osteopontin (OPN) is a cytokine related to cell-matrix adhesion and cell survival and is expressed in the distal convoluted tubules in normal adult kidneys. Only one in vitro study... -
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- Interleukin-13 Increases Podocyte Apoptosis in Cultured Human Podocytes
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Lee KH, Oh JY, Seong SB, Ha TS, Shin JI
- KMID: 2435351
- Child Kidney Dis.
- 2018 Apr;22(1):22-27.
- doi: 10.3339/jkspn.2018.22.1.22
PURPOSE: Podocytes are important architectures that maintain the crucial roles of glomerular filtration barrier functions. Despite this structural importance, however, the mechanisms of the changes in podocytes that can be... -
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- Genetics of hereditary nephrotic syndrome: a clinical review
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Ha TS
- KMID: 2375167
- Korean J Pediatr.
- 2017 Mar;60(3):55-63.
- doi: 10.3345/kjp.2017.60.3.55
Advances in podocytology and genetic techniques have expanded our understanding of the pathogenesis of hereditary steroid-resistant nephrotic syndrome (SRNS). In the past 20 years, over 45 genetic mutations have been... -
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- Mechanism of Podocyte Injury in Diabetic Nephropathy
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Lee EY, Song JS, Chung CH, Hong SY
- KMID: 2331750
- J Korean Diabetes Assoc.
- 2003 Aug;27(4):343-351.
BACKGROUND: Since podocytes are involved in the maintenance of filtration barrier and normal structure in the kidney, podocyte injury can cause the disturbance of glomerular permselectivity and resultant proteinuria, and... -
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- Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
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Lee JH, Oh MH, Park JS, Na GJ, Gil HW, Yang JO, Lee EY, Hong SY
- KMID: 1792033
- Korean J Intern Med.
- 2014 Mar;29(2):176-182.
- doi: 10.3904/kjim.2014.29.2.176
BACKGROUND/AIMS: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA)... -
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- Diabetic conditions modulate the adenosine monophosphate-activated protein kinase of podocytes
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Ha TS, Park HY, Nam JA, Han GD
- KMID: 2224283
- Kidney Res Clin Pract.
- 2014 Mar;33(1):26-32.
BACKGROUND: Adenosine monophosphate-activated protein kinases (AMPKs), as a sensor of cellular energy status, have been known to play an important role in the pathophysiology of diabetes and its complications. Because... -
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- Nonimmunologic targets of immunosuppressive agents in podocytes
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Yoo TH, Fornoni A
- KMID: 2381520
- Kidney Res Clin Pract.
- 2015 Jun;34(2):69-75.
- doi: 10.1016/j.krcp.2015.03.003
Proteinuria is a characteristic finding in glomerular diseases and is closely associated with renal outcomes. In addition, therapeutic interventions that reduce proteinuria improve renal prognosis. Accumulating evidence has demonstrated that... -
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- Podocytopathy and Morphologic Changes in Focal Segmental Glomerulosclerosis
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Jeong HJ
- KMID: 2196619
- J Korean Soc Pediatr Nephrol.
- 2013 Apr;17(1):13-18.
Podocytopathy is glomerular lesions characterized by podocyte injury. It is observed in various glomerular diseases, but minimal change disease and focal segmental glomerulosclerosis (FSGS) are the prototypes. In this review,... -
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- Crystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma
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Lee EJ, Lee SY, Park SY, Kim Y, Choi JS, Kim MJ, Park JH, Lee JE, Kwon GY, Kim YG
- KMID: 2364293
- Kidney Res Clin Pract.
- 2016 Dec;35(4):259-262.
- doi: 10.1016/j.krcp.2016.06.001
Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain–secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause... -
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- Puromycin aminonucleoside modulates p130Cas of podocytes
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Ha TS, Choi JY, Park HY
- KMID: 2140712
- Korean J Pediatr.
- 2012 Oct;55(10):371-376.
- doi: 10.3345/kjp.2012.55.10.371
PURPOSE: Puromycin aminonucleoside (PAN) specifically injures podocytes, leading to foot process effacement, actin cytoskeleton disorganization, and abnormal distribution of slit diaphragm proteins. p130Cas is a docking protein connecting F-actin fibers... -
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- The Effect of High Glucose on Renin-Angiotensin System (RAS) in Podocytes
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Yoo TH, Ryu DR, Lee JJ, Kim JJ, Jung DS, Kwak SJ, Xu ZG, Kim JS, Kim HJ, Choi HY, Han DS, Kang SW
- KMID: 1867693
- Korean J Nephrol.
- 2006 Nov;25(6):903-912.
The renin-angiotensin system (RAS) plays an important role in the pathogenesis of diabetic nephropathy. Recently, the activation of local RAS in mesangial cells by high glucose has been reported. However,... -
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- The Effect of Bradykinin on High-Glucose Induced Apoptosis in Cultured Podocytes
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Kwak SJ, Yoo TH, Kang SW, Kim KJ, Baek DH, Kim WS, An HR, Yu M, Kim SJ, Kang DH, Choi KB, Ryu DR
- KMID: 2330952
- J Korean Soc Hypertens.
- 2010 Mar;16(1):8-17.
BACKGROUND: In this study, we examined whether a local kallikrein-kinin system (KKS) exists in podocytes and whether expression of the components of the KKS and bradykinin (BK) production are changed... -
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- GLCCI1 is a novel component associated with the PI3K signaling pathway in podocyte foot processes
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Kim SH, Kim HJ, Kim CW
- KMID: 2361520
- Exp Mol Med.
- 2016 May;48(5):e233.
- doi: 10.1038/emm.2016.28
Podocyte foot processes are interdigitated to form the slit diaphragm and are crucial for the glomerular filtration barrier. Glucocorticoid-induced transcript 1 (GLCCI1) is transcriptionally regulated, but its signaling pathway in... -
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- Effects of Interleukin-13 and Montelukast on the Expression of Zonula Occludens-1 in Human Podocytes
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Park SJ, Saleem MA, Nam JA, Ha TS, Shin JI
- KMID: 2070020
- Yonsei Med J.
- 2015 Mar;56(2):426-432.
- doi: 10.3349/ymj.2015.56.2.426
PURPOSE: The aim of this study was to investigate whether pathologic changes in zonula occludens-1 (ZO-1) are induced by interleukin-13 (IL-13) in the experimental minimal-change nephrotic syndrome (MCNS) model and... -
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- Podocyte-specific Expression of C1q/TNF-alpha Related Protein 1 in Mice
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Cho KJ, Yang Y, Lee YH, Kim S
- KMID: 1502524
- Korean J Phys Anthropol.
- 2013 Dec;26(4):147-153.
- doi: 10.11637/kjpa.2013.26.4.147
C1q/TNF-alpha Related Protein 1 (CTRP1), an adiponectin paralog, is a novel member of the C1q-TNF Related Protein family. CTRP1 is expressed in the kidney, although its localization and role in... -
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- Ginseng Total Saponin Improves Podocyte Hyperpermeability Induced by High Glucose and Advanced Glycosylation Endproducts
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Ha TS, Choi JY, Park HY, Lee JS
- KMID: 1785989
- J Korean Med Sci.
- 2011 Oct;26(10):1316-1321.
- doi: 10.3346/jkms.2011.26.10.1316
Early diabetic nephropathy is characterized by glomerular hyperpermeability as a result of impaired glomerular filtration structure caused by hyperglycemia, glycated proteins or irreversible advanced glycosylation endproducts (AGE). To investigate the... -
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- New insights into the role of renal resident cells in the pathogenesis of lupus nephritis
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Kwok SK, Tsokos GC
- KMID: 2411538
- Korean J Intern Med.
- 2018 Mar;33(2):284-289.
- doi: 10.3904/kjim.2017.383
Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE... -
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