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Drug Resistance and in Vitro Susceptibility of Plasmodium falciparum in Thailand during 1988-2003

Suwandittakul N, Chaijaroenkul W, Harnyuttanakorn P, Mungthin M, Na Bangchang K

The aim of the present study was to investigate antimalarial drug pressure resulting from the clinical use of different antimalarials in Thailand. The phenotypic diversity of the susceptibility profiles of...
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Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin

Lee SJ, Oh ST, Park GM, Kim TS, Ryu JS, Choi HK

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to...
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Gametocyte Clearance in Uncomplicated and Severe Plasmodium falciparum Malaria after Artesunate-Mefloquine Treatment in Thailand

Tangpukdee N, Krudsood S, Srivilairit S, Phophak N, Chonsawat , Yanpanich , Kano S, Wilairatana P

Artemisinin-based combination therapy (ACT) is currently promoted as a strategy for treating both uncomplicated and severe falciparum malaria, targeting asexual blood-stage Plasmodium falciparum parasites. However, the effect of ACT on...
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Sensitivity of Plasmodium falciparum to Antimalarial Drugs in Hainan Island, China

Wang SQ, Wang GZ, Li YC, Meng F, Lin SG, Zhu ZH, Sun DW, He CH, Hu XM, Du JW

Pyronaridine and artesunate have been shown to be effective in falciparum malaria treatment. However, pyronaridine is rarely used in Hainan Island clinically, and artesunate is not widely used as a...
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