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Personalized Psychiatry and Depression: The Role of Sociodemographic and Clinical Variables

Perna G, Alciati A, Daccò S, Grassi M, Caldirola

Despite several pharmacological options, the clinical outcomes of major depressive disorder (MDD) are often unsatisfactory. Personalized psychiatry attempts to tailor therapeutic interventions according to each patient’s unique profile and characteristics....
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The role of regional analgesia in personalized postoperative pain management

Chitnis SS, Tang R, Mariano ER

Pain management plays a fundamental role in enhanced recovery after surgery pathways. The concept of multimodal analgesia in providing a balanced and effective approach to perioperative pain management is widely...
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Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs

Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F

BACKGROUND: Osteoarthritis (OA) is a highly prevalent degenerative joint disease involving joint cartilage and its surrounding tissues. OA is the leading cause of pain and disability worldwide. At present, there...
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Neonatal transient pseudohypoparathyroidism: could it be included among inactivating parathyroid hormone (PTH)/PTH-related protein signalling disorders?

De Rose DU, Perri A, Gallini F, Priolo F, Tiberi E, Vento G, Zecca E

We report a case of transient pseudohypoparathyroidism in a full-term newborn that presented at 20 hours of life with hypocalcemic seizures, hyperphosphatemia and raised parathormone levels. The diagnosis of pseudohypoparathyroidism...
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A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation

Kim SH, Noh MY, Kim HJ, Oh KW, Park J, Lee S, Moon Y, Kim YE, Bae JS, Jin HK, K-ARPI

Alzheimer's disease (AD), the most common form of dementia, has emerged as a major global public health challenge. However, the complexity of AD in its biological, genetic, and clinical aspects...
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Perspectives in Radiomics for Personalized Medicine and Theranostics

Ha S

Radiomics handles imaging biomarker from high-throughput feature extraction through complex pattern recognition that is difficult for human to process. Recent medical paradigms are rapidly changing to personalized medicine, including molecular...
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Molecular Imaging in Breast Cancer

Miladinova D

Breast cancer (BC) is themost common cancer among females withmore than 2 million new cases diagnosed worldwide in 2018. Although the prognosis in the majority of cases in the early...
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Biologic agents for asthma treatment

Kim SR, Lee JH

Most treatment strategies for asthma currently include inhaled corticosteroids, with the addition of long-acting beta-2-agonists or leukotriene modifiers, if necessary. However, some patients may not respond to conventional treatment. A...
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The Generation and Application of Patient-Derived Xenograft Model for Cancer Research

Jung J, Seol HS, Chang S

Establishing an appropriate preclinical model is crucial for translational cancer research. The most common way that has been adopted by far is grafting cancer cell lines, derived from patients. Although...
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Ultra-rare Disease and Genomics-Driven Precision Medicine

Lee S, Choi M

Since next-generation sequencing (NGS) technique was adopted into clinical practices, revolutionary advances in diagnosing rare genetic diseases have been achieved through translating genomic medicine into precision or personalized management. Indeed,...
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Reference Values for a Panel of Cytokinergic and Regulatory Lymphocyte Subpopulations

Sorrenti V, Marenda B, Fortinguerra S, Cecchetto , Quartesan , Zorzi G, Zusso M, Giusti P, Buriani A

Lymphocyte subpopulations producing cytokines and exerting regulatory functions represent key immune elements. Given their reciprocal interdependency lymphocyte subpopulations are usually assayed as diagnostic panels, rather than single biomarkers for specialist...
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Biomarkers of adult asthma and personalized medicine

Sim DW, Lee JH

The concept of personalized medicine for disease diagnosis, treatment, and management, considering individual variability, including susceptibility, clinical manifestations, and drug responsiveness, is a global emerging trend in medicine, which is...
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Cancer Cell Line Panels Empower Genomics-Based Discovery of Precision Cancer Medicine

Kim HS, Sung YJ, Paik S

Since the first human cancer cell line, HeLa, was established in the early 1950s, there has been a steady increase in the number and tumor type of available cancer cell...
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Preclinical Assessment of the Anticancer Drug Response of Plexiform Neurofibroma Tissue Using Primary Cultures

Jiang W, Mautner VF, Friedrich , Kluwe L

BACKGROUND AND PURPOSE: Individualized drug testing for tumors using a strategy analogous to antibiotic tests for infectious diseases would be highly desirable for personalized and individualized cancer care. METHODS: Primary cultures...
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Personalized treatment of hepatitis B

Lok AS

There are seven approved drugs for treatment of hepatitis B. Professional guidelines provide a framework for managing patients but these guidelines should be interpreted in the context of the individual...
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Pharmacometabolomics: Current Applications and Future Perspectives

Kim HJ, Yoon YR

  • KMID: 2317851
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):8-10.
Metabolomics, a novel "omics" platform, is a powerful tool for the discovery of clinically useful biomarkers and biochemical processes to improve diagnosis and therapy. Through the use of advanced analytical...
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Comprehensive Variant Screening of the UGT Gene Family

Kim JY, Cheong HS, Park BL, Kim LH, Namgoong S, Kim JO, Kim HD, Kim YH, Chung MW, Han SY, Shin HD

PURPOSE: UGT1A1, UGT2B7, and UGT2B15 are well-known pharmacogenes that belong to the uridine diphosphate glucuronyltransferase gene family. For personalized drug treatment, it is important to study differences in the frequency...
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Biomarkers for Stroke

Kim SJ, Moon GJ, Bang OY

  • KMID: 2223736
  • J Stroke.
  • 2013 Jan;15(1):27-37.
BACKGROUND: Major stroke clinical trials have failed during the past decades. The failures suggest the presence of heterogeneity among stroke patients. Biomarkers refer to indicators found in the blood, other...
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Personalized Medicine in Cardiovascular Diseases

Lee MS, Flammer AJ, Lerman LO, Lerman A

Personalized medicine is a novel medical model with all decisions and practices being tailored to individual patients in whatever ways possible. In the era of genomics, personalized medicine combines the...
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Oncoplastic Surgical Techniques for Personalized Breast Conserving Surgery in Breast Cancer Patient with Small to Moderate Sized Breast

Yang JD, Lee JW, Kim WW, Jung JH, Park HY

Oncoplastic surgery has revolutionized the field of breast conserving surgery (BCS). The final aims of this technique are to obtain an adequate resection margin that will reduce the rate of...
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