- Design, Synthesis, and Functional Evaluation of 1, 5-Disubstituted Tetrazoles as Monoamine Neurotransmitter Reuptake Inhibitors
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Paudel S, Wang S, Kim E, Kundu D, Min X, Shin CY, Kim KM
- KMID: 2526822
- Biomol Ther.
- 2022 Mar;30(2):191-202.
- doi: 10.4062/biomolther.2021.119
Tetrazoles were designed and synthesized as potential inhibitors of triple monoamine neurotransmitters (dopamine, norepinephrine, serotonin) reuptake based on the functional and docking simulation of compound 6 which were performed in... -
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- Structural Requirements for Modulating 4-Benzylpiperidine Carboxamides from Serotonin/Norepinephrine Reuptake Inhibitors to Triple Reuptake Inhibitors
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Paudel S, Kim E, Zhu A, Acharya S, Min X, Cheon SH, Kim KM
- KMID: 2517157
- Biomol Ther.
- 2021 Jul;29(4):392-398.
- doi: 10.4062/biomolther.2020.233
In this study, we determined the effect of 24 different synthetic 4-benzylpiperidine carboxamides on the reuptake of serotonin, norepinephrine, and dopamine (DA), and characterized their structure–activity relationship. The compounds with... -
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- Comparative Pre-clinical Efficacy of Chinese and Indian Cultivars of Bitter Melon (Momordica charantia) against Pancreatic Cancer
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Kandhari K, Paudel S, Raina K, Agarwal C, Kant R, Wempe MF, Bryant CO, Agarwal R
- KMID: 2524121
- J Cancer Prev.
- 2021 Dec;26(4):266-276.
- doi: 10.15430/JCP.2021.26.4.266
Given the high rates of incidence and mortality associated with pancreatic cancer (PanC), there is a need to develop alternative strategies to target PanC. Recent studies have demonstrated that fruits... -
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- Structure–Activity Relationship and Evaluation of Phenethylamine and Tryptamine Derivatives for Affinity towards 5-Hydroxytryptamine Type 2A Receptor
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Wang S, Zhu A, Paudel S, Jang CG, Lee YS, Kim KM
- KMID: 2539586
- Biomol Ther.
- 2023 Mar;31(2):176-182.
- doi: 10.4062/biomolther.2022.096
Among 14 subtypes of serotonin receptors (5-HTRs), 5-HT 2AR plays important roles in drug addiction and various psychiatric disorders. Agonists for 5-HT 2AR have been classified into three structural groups:... -
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- Novel GPR43 Agonists Exert an Anti-Inflammatory Effect in a Colitis Model
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Park BO, Kang JS, Paudel S, Park SG, Park BC, Han SB, Kwak YS, Kim JH, Kim S
- KMID: 2524146
- Biomol Ther.
- 2022 Jan;30(1):48-54.
- doi: 10.4062/biomolther.2021.078
GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism. GPR43 couples with Gα i/o and Gα... -
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- Potential Functional Role of Phenethylamine Derivatives in Inhibiting Dopamine Reuptake: Structure–Activity Relationship
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Kundu D, Zhu A, Kim E, Paudel S, Jang CG, Lee YS, Kim KM
- KMID: 2537587
- Biomol Ther.
- 2023 Jan;31(1):108-115.
- doi: 10.4062/biomolther.2022.047
Numerous psychotropic and addictive substances possess structural features similar to those of β-phenethylamine (β-PEA). In this study, we selected 29 β-PEA derivatives and determined their structure–activity relationship (SAR) to their... -
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