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Damage-Associated Molecular Patterns in Inflammatory Diseases

Roh JS, Sohn DH

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although...
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Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation

Lu TF, Yang TH, Zhong CP, Shen C, Lin WW, Gu GX, Xia Q, Xu N

Ischemia-reperfusion injury (IRI) is a major complication in liver transplantation (LT) and it is closely related to the recovery of grafts' function. Researches has verified that both innate and adaptive...
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NOD-Like Receptors in Infection, Immunity, and Diseases

Kim YK, Shin JS, Nahm MH

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are pattern-recognition receptors similar to toll-like receptors (TLRs). While TLRs are transmembrane receptors, NLRs are cytoplasmic receptors that play a crucial role in...
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Polyionic vaccine adjuvants: another look at aluminum salts and polyelectrolytes

Powell BS, Andrianov , Fusco PC

Adjuvants improve the adaptive immune response to a vaccine antigen by modulating innate immunity or facilitating transport and presentation. The selection of an appropriate adjuvant has become vital as new...
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Autophagy in Innate Recognition of Pathogens and Adaptive Immunity

Oh JE, Lee HK

Autophagy is a specialized cellular pathway involved in maintaining homeostasis by degrading long-lived cellular proteins and organelles. Recent studies have demonstrated that autophagy is utilized by immune systems to protect...
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Clinical Approaches for Understanding the Expression Levels of Pattern Recognition Receptors in Otitis Media with Effusion

Lee SY, Ryu EW, Kim JB, Yeo SG

  • KMID: 2166395
  • Clin Exp Otorhinolaryngol.
  • 2011 Dec;4(4):163-167.
OBJECTIVES: Bacterial infections in the normally sterile environment of the middle ear cavity usually trigger host immune response, whereby the innate immune system plays a dominant role as the host's...
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