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Involvement of Oxidative Stress in Cisplatin-Induced Apoptosis in HeLa Cells

Ko KH, Kim SH, Cho HJ, Oh SH, Kim HG, Park RG

  • KMID: 1925291
  • Korean J Obstet Gynecol.
  • 2003 Dec;46(12):2410-2416.
OBJECTIVE: To determine whether oxidants are formed as part of the cisplatin-induced apoptotic process, intracellular markers of oxidative stress were examined. METHODS: Apoptotic death of HeLa cells by cisplatin was confirmed...
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The Study of the Cytotoxic Mechanism of Cisplatin in HeLa Cells

Choi JH, Cho H, Lee SY, Oh SH, Kim HG, Park RG

  • KMID: 2076939
  • Korean J Obstet Gynecol.
  • 2003 Oct;46(10):1989-1998.
Cis-diamminedichloroplatinum II (cisplatin) has been reported to induce cell death. However, the mechanism by which cisplatin is induced the apoptosis of cancer cells is still unclear. To evaluate the mechanistic...
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The Mechanism of Intracellular Signal Pathway that Baicalin Hydrate Elevate Chemotherapeutic Response of Cervical Carcinoma

Kim BR, Kim IS, Ko KH, Lee JJ, Kim HG, Park RG

  • KMID: 2076936
  • Korean J Obstet Gynecol.
  • 2003 Oct;46(10):1965-1974.
Baicalin is flavonoid and major component of PC-SPES. Flavonoids including baicalin have been reported to not only function as anti-oxidant but also cause cytotoxic effect. Baicalin hydrate has been reported...
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