- Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
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Jiang S, Uddin MJ, Yu X, Piao L, Dorotea D, Oh GT, Ha H
- KMID: 2536142
- Diabetes Metab J.
- 2022 Nov;46(6):829-842.
- doi: 10.4093/dmj.2021.0274
Background: Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and diabetes. Peroxisomes are single membrane-enclosed organelles that play a role in the metabolism... -
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- Didymin Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the PPAR Signaling Pathway
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Li Q, Zhang H, Liu X
- KMID: 2533398
- Yonsei Med J.
- 2022 Oct;63(10):956-965.
- doi: 10.3349/ymj.2022.0040
Purpose: Cerebral ischemia-reperfusion (IR) injury is a severe secondary injury induced by reperfusion after stroke. Didymin has been reported to have a protective effect on intracerebral hemorrhage. However, the underlying... -
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- Lipoprotein Lipase: Is It a Magic Target for the Treatment of Hypertriglyceridemia
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Moon JH, Kim K, Choi SH
- KMID: 2532857
- Endocrinol Metab.
- 2022 Aug;37(4):575-586.
- doi: 10.3803/EnM.2022.402
High levels of triglycerides (TG) and triglyceride-rich lipoproteins (TGRLs) confer a residual risk of cardiovascular disease after optimal low-density lipoprotein cholesterol (LDL-C)–lowering therapy. Consensus has been made that LDL-C is... -
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- New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins
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Kim K, Ginsberg HN, Choi SH
- KMID: 2531956
- Diabetes Metab J.
- 2022 Jul;46(4):517-532.
- doi: 10.4093/dmj.2022.0198
Statins are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, even under optimal statin therapy, a significant residual ASCVD risk remains. Therefore, there has been... -
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- Anti-metastatic Effect of Natural Product-motivated Synthetic PPAR-γ Ligands
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Li Dd, Wang Y, Ju Z, Kim EL, Hong J, Jung JH
- KMID: 2530936
- Nat Prod Sci.
- 2022 Jun;28(2):80-88.
- doi: 10.20307/nps.2022.28.2.80
Colorectal cancer is one of the most common cancers globally, ranking second for the number of cancer-related deaths. Metastasis has been reported as the main cause of death in patients... -
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- Lobeglitazone, A Peroxisome Proliferator-Activated Receptor-Gamma Agonist, Inhibits Papillary Thyroid Cancer Cell Migration and Invasion by Suppressing p38 MAPK Signaling Pathway
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Jin JQ, Han JS, Ha J, Baek HS, Lim DJ
- KMID: 2521957
- Endocrinol Metab.
- 2021 Oct;36(5):1095-1110.
- doi: 10.3803/EnM.2021.1155
Background: Peroxisome proliferator-activated receptor-gamma (PPAR-γ) ligands have been widely shown to correlate with epithelial-mesenchymal transition (EMT) and cancer progression. Lobeglitazone (LGZ) is a novel ligand of PPAR-γ; and its role... -
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- Inhibitory effect of ethanolic extract of Abeliophyllum distichum leaf on 3T3–L1 adipocyte differentiation
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Thomas SS, Eom J, Sung NY, Kim DS, Cha YS, Kim KA
- KMID: 2520658
- Nutr Res Pract.
- 2021 Oct;15(5):555-567.
- doi: 10.4162/nrp.2021.15.5.555
BACKGROUND/OBJECTIVES: Abeliophyllum distichum is a plant endemic to Korea, containing several beneficial natural compounds. This study investigated the effect of A. distichum leaf extract (ALE) on adipocyte differentiation. MATERIALS/METHODS: The cytotoxic... -
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- Cyclooxygenase-2 Inhibitor Parecoxib Was Disclosed as a PPAR-γ Agonist by In Silico and In Vitro Assay
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Xiao B, Li Dd, Wang Y, Kim EL, Zhao N, Jin SW, Bai DH, Sun LD, Jung JH
- KMID: 2519617
- Biomol Ther.
- 2021 Sep;29(5):519-526.
- doi: 10.4062/biomolther.2021.008
In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib... -
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- Protective effects of lutein against vancomycin-induced acute renal injury in mice via upregulation of peroxisome proliferatoractivated receptor gamma/nuclear factor erythroid 2-related factor 2 and inhibition nuclear factor-kappaB/caspase 3
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Emeka PM, Rasool ST, Morsy MA, Hairul Islam MI, Chohan MS
- KMID: 2516871
- Korean J Physiol Pharmacol.
- 2021 Jul;25(4):321-331.
- doi: 10.4196/kjpp.2021.25.4.321
Vancomycin, an antibiotic used occasionally as a last line of treatment for methicillin-resistant Staphylococcus aureus, is reportedly associated with nephrotoxicity. This study aimed at evaluating the protective effects of lutein... -
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- Optimization of adipogenic differentiation conditions for canine adipose-derived stem cells
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Kim JY, Park EJ, Kim SM, Lee HJ
- KMID: 2518799
- J Vet Sci.
- 2021 Jul;22(4):e53.
- doi: 10.4142/jvs.2021.22.e53
Background: Canine adipose-derived stem cells (cADSCs) exhibit various differentiation properties and are isolated from the canine subcutaneous fat. Although cADSCs are valuable as tools for research on adipogenic differentiation, studies... -
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- Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF-κB and PPAR-γ pathways
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Mohamed ME, Elsayed SA, Madkor HR, Eldien HMS, Mohafez OM
- KMID: 2515478
- Intest Res.
- 2021 Apr;19(2):194-205.
- doi: 10.5217/ir.2020.00021
Background/Aims: Ulcerative colitis (UC) is a chronic inflammatory disorder with indefinite etiology; however, environmental, genetic, immune factors and microbial agents could be implicated in its pathogenesis. UC treatment is lifelong,... -
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- Mechanism of Lipid Accumulation through PAR2 Signaling in Diabetic Male Mice
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Kim DH, Kim YR, Bang E, Ha S, Noh SG, Kim BM, Jeong SH, Jung HJ, Lee JY, Chung HY
- KMID: 2513300
- Endocrinol Metab.
- 2021 Feb;36(1):171-184.
- doi: 10.3803/EnM.2020.850
Background: Protease-activated protein-2 (PAR2) has been reported to regulate hepatic insulin resistance condition in type 2 diabetes mice. However, the mechanism of lipid metabolism through PAR2 in obesity mice have... -
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- Impaired liver regeneration and lipid homeostasis in CCl4 treated WDR13 deficient mice
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Mishra AP, Siva AB, Gurunathan C, Komala Y, Lakshmi BJ
- KMID: 2510410
- Lab Anim Res.
- 2020 Dec;36(4):318-327.
- doi: 10.1186/s42826-020-00076-8
WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation,... -
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- Fibrates Revisited: Potential Role in Cardiovascular Risk Reduction
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Kim NH, Kim SG
- KMID: 2502402
- Diabetes Metab J.
- 2020 Apr;44(2):213-221.
- doi: 10.4093/dmj.2020.0001
Fibrates, peroxisome proliferator-activated receptor-α agonists, are potent lipid-modifying drugs. Their main effects are reduction of triglycerides and increase in high-density lipoprotein levels. Several randomized controlled trials have not demonstrated their... -
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- Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice
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Hsiao WT, Su HM, Su KP, Chen SH, Wu HP, You YL, Fu RH, Chao PM
- KMID: 2453106
- Nutr Res Pract.
- 2019 Aug;13(4):286-294.
- doi: 10.4162/nrp.2019.13.4.286
BACKGROUND/OBJECTIVES: Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LCPUFA), is acquired by dietary intake or the in vivo conversion of α-linolenic acid. Many enzymes participating in LCPUFA... -
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- Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation in cultured human keratinocytes
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Bae IH, Lee SH, Oh S, Choi H, Marinho PA, Yoo JW, Ko JY, Lee ES, Lee TR, Lee CS, Kim DY
- KMID: 2438085
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):113-120.
- doi: 10.4196/kjpp.2019.23.2.113
Mannosylerythritol lipids (MELs) are glycolipids and have several pharmacological efficacies. MELs also show skin-moisturizing efficacy through a yet-unknown underlying mechanism. Aquaporin-3 (AQP3) is a membrane protein that contributes to the... -
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- Inhibition of miR-128 Abates Aβ-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells
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Geng L, Zhang T, Liu W, Chen Y
- KMID: 2422495
- Yonsei Med J.
- 2018 Nov;59(9):1096-1106.
- doi: 10.3349/ymj.2018.59.9.1096
PURPOSE: Alzheimer's disease (AD) is the sixth most common cause of death in the United States. MicroRNAs have been identified as vital players in neurodegenerative diseases, including AD. microRNA-128 (miR-128)... -
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- Effect of Pioglitazone in Combination with Moderate Dose Statin on Atherosclerotic Inflammation: Randomized Controlled Clinical Trial Using Serial FDG-PET/CT
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Choo EH, Han EJ, Kim CJ, Kim SH, O JH, Chang K, Seung KB
- KMID: 2414893
- Korean Circ J.
- 2018 Jul;48(7):591-601.
- doi: 10.4070/kcj.2017.0029
BACKGROUND AND OBJECTIVES: Non-statin therapy plus lower intensity statin might be an alternative in patients with coronary artery disease (CAD). A recent data suggested an anti-inflammatory therapy can reduce recurrent... -
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- Peroxisome proliferator-activated receptor gamma agonist as a novel treatment for interstitial cystitis: A rat model
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Mahal A, Young-Lin , Dobberfuhl A, Estes J, Comiter CV
- KMID: 2414759
- Investig Clin Urol.
- 2018 Jul;59(4):257-262.
- doi: 10.4111/icu.2018.59.4.257
PURPOSE: To understand the therapeutic potential of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist with a propensity to cause bladder mucosal proliferation, on interstitial cystitis (IC) in a rat... -
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- Troglitazone Inhibits Matrix Metalloproteinase-9 Expression and Invasion of Breast Cancer Cell through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism
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Hong OY, Youn HJ, Jang HY, Jung SH, Noh EM, Chae HS, Jeong YJ, Kim W, Kim CH, Kim JS
- KMID: 2441865
- J Breast Cancer.
- 2018 Mar;21(1):28-36.
- doi: 10.4048/jbc.2018.21.1.28
PURPOSE: Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. Matrix metalloproteinases (MMPs) play a significant role in tissue remodeling... -
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