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Chemosensitizing effect and mechanism of imperatorin on the anti-tumor activity of doxorubicin in tumor cells and transplantation tumor model

Liang Xl, Ji Mm, Liao Zg, Zhao Gw, Tang Xl, Dong W

Multidrug resistance of tumors has been a severe obstacle to the success of cancer chemotherapy. The study wants to investigate the reversal effects of imperatorin (IMP) on doxorubicin (DOX) resistance...
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Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma

Kim SH, Seung BJ, Cho SH, Lim HY, Bae MK, Sur JH

Background Hepatocellular carcinoma is the most common primary hepatic malignancy in humans and dogs. Several differentially expressed molecules have been studied and reported in human hepatocellular carcinoma and non-neoplastic liver lesions....
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Oncogenic Ras downregulates mdr1b expression through generation of reactive oxygen species

Jun S, Kim SW, Kim B, Chang IY, Park SJ

In the present study, we investigated the effect of oncogenic H-Ras on rat mdr1b expression in NIH3T3 cells. The constitutive expression of H-RasV12 was found to downregulate the mdr1b promoter...
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Renal tubular P-glycoprotein expression is reduced in plasma cell disorders

Heybeli C, Oktan MA, Arda HU, Yildiz S, Unlu M, Cavdar C, Sifil A, Celik A, Sarioglu S, Camsari T

BACKGROUND: P-glycoprotein (P-gp) transports many chemicals that vary greatly in their structure and function. It is normally expressed in renal proximal tubular cells. We hypothesized that P-gp expression influences light...
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Development of an oligonucleotide microarray for simultaneous detection of two canine MDR1 genotypes and association between genotypes and chemotherapy side effects

Lee JJ, Lin HY, Chen CA, Lin CS, Wang LC

Canine MDR1 gene mutations produce translated P-glycoprotein, an active drug efflux transporter, resulting in dysfunction or over-expression. The 4-base deletion at exon 4 of MDR1 at nucleotide position 230 (nt230[del4])...
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Effects of Adamantyl Derivatives on Pharmacokinetic Behavior of Paclitaxel in Rats

Kim KM, Lee K, Jang K, Moon YS, Lee HJ, Rhie SJ

Paclitaxel (PTX) is one of the most frequently used anticancer agent for treating refractory ovarian cancer, metastatic breast cancer and non-small cell lung cancer. However, its oral administration is impeded...
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Role of the ABCB1 Drug Transporter Polymorphisms in the Pharmacokinetics of Oseltamivir in Humans: a Preliminary Report

Cha YJ, Ghim JL

Oseltamivir is a substrate of P-glycoprotein, an efflux drug transporter encoded by ABCB1. The objective of this study was to assess the role of ABCB1 (c.1236C>T, c.2677G>T/A, and c.3435C>T) polymorphisms...
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Association between ABCB1 Polymorphisms and Antidepressant Treatment Response in Taiwanese Major Depressive Patients

Chang HH, Chou CH, Yang YK, Lee IH, Chen PS

OBJECTIVE: The multidrug resistance 1 (ABCB1, MDR1) gene, encoding P-glycoprotein, is extensively distributed and expressed in various tissues, such as a blood-brain barrier transporter. P-glycoprotein plays an important role in...
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A Phase I Study of Oral Paclitaxel with a Novel P-Glycoprotein Inhibitor, HM30181A, in Patients with Advanced Solid Cancer

Lee HJ, Heo DS, Cho JY, Han SW, Chang HJ, Yi HG, Kim TE, Lee SH, Oh DY, Im SA, Jang IJ, Bang YJ

  • KMID: 2167688
  • Cancer Res Treat.
  • 2014 Jul;46(3):234-242.
PURPOSE: The purpose of this study is to determine the maximum tolerated dose (MTD), safety, pharmacokinetics, and recommended phase II dose of an oral drug composed of paclitaxel and HM30181A,...
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Identification of P-Glycoprotein and Transport Mechanism of Paclitaxel in Syncytiotrophoblast Cells

Lee NY, Lee HE, Kang YS

  • KMID: 2048333
  • Biomol Ther.
  • 2014 Jan;22(1):68-72.
When chemotherapy is administered during pregnancy, it is important to consider the fetus chemotherapy exposure, because it may lead to fetal consequences. Paclitaxel has become widely used in the metastatic...
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Selective cyclooxygenase inhibitors increase paclitaxel sensitivity in taxane-resistant ovarian cancer by suppressing P-glycoprotein expression

Lee JP, Hahn HS, Hwang SJ, Choi JY, Park JS, Lee IH, Kim TJ

OBJECTIVE: The purpose of this study was to investigate whether selective cyclooxygenase (COX) inhibitors promote paclitaxel-induced apoptosis in taxane-resistant ovarian cancer cells by suppressing MDR1/P-glycoprotein (P-gp) expression. METHODS: Taxane-resistant ovarian cancer...
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Effects of Fluvastatin on the Pharmacokinetics of Repaglinide: Possible Role of CYP3A4 and P-glycoprotein Inhibition by Fluvastatin

Lee CK, Choi JS, Bang JS

The purpose of this study was to investigate the effects of fluvastatin on the pharmacokinetics of repaglinide in rats. The effect of fluvastatin on P-glycoprotein and CYP3A4 activity was evaluated....
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A Case of Successful Treatment of Cutaneous Aspergillosis with Voriconazole at the Low Cyclosporine Trough Level in a Renal Transplant

Park SJ

Aspergillosis is a serious infectious complication with high mortality in transplant recipients. Voriconazole is a broad spectrum triazole antifungal agent, but it has a drug-drug interaction with immunosuppressants. Herein we...
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Expression of P-glycoprotein and Apoptosis in Diffuse Large B-cell Lymphoma

Kim JE, Kim YA, Chang MS, Jeon Y, Paik J, Yoon SO

  • KMID: 2459590
  • Korean J Pathol.
  • 2009 Aug;43(4):317-320.
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma which responds well to conventional chemotherapy. However, quite a few patients have a recurrence with more...
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Effects of the polymorphic MDR1 genotype on the single-dose simvastatin pharmacokinetics in healthy subjects

Sung JH, Han SS, Lee ME, Ha KS, Kim WJ

  • KMID: 2258576
  • Korean J Med.
  • 2009 Aug;77(2):211-217.
BACKGROUND/AIMS: Simvastatin has dramatically reduced cardiovascular disease due to elevated cholesterol. The human multidrug resistance 1 gene (MDR1) encodes a 170-kDa transmembrane glycoprotein (P-glycoprotein), which plays an important role in...
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Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability

Lee W, Choi HI, Kim MJ, Park SY

The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the carcinogenesis. However, whether the depletion of mtDNA induces multidrug resistance in cancer cells has not...
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Expressions of cyclooxygenase-2 and P-glycoprotein in epithelial ovarian carcinomas

Jung SK, Kang JS, Kim IS

  • KMID: 2273175
  • Korean J Obstet Gynecol.
  • 2007 Sep;50(9):1205-1215.
OBJECTIVES: The purpose of this study was to evaluate expression of cyclooxygenase-2 (COX-2) and P-glycoprotein (P-gp) in ovarian epithelial carcinomas, to find out the correlations between their expression and clinicopathological...
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Epileptogenic Properties of Balloon Cells in Cortical Tubers of Tuberous Sclerosis: Upregulation of Drug Resistance Proteins

Kang NG, Chang HJ, Ok YC, Lee RS, Park SK, Lim JS, Cho KY, Kim HI, Kim JH, Oh HS, Lee MC

  • KMID: 1956262
  • J Korean Neurosurg Soc.
  • 2007 Jun;41(6):397-402.
OBJECTIVES: Balloon cells and dysplastic neurons are histopathological hallmarks of the cortical tubers of tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) of the Taylor type. They are believed...
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The Multidrug Resistance-related Protein and P-glycoprotein Expressions, and the Washout Rates of 99mTc-MIBI in Infiltrating Ductal Carcinoma of Breast, Correlation with the Response After Neoadjuvant Chemotherapy

Kwak HS, Bae YT, Han KT, Kim IJ

PURPOSE: Numerous non-invasive imaging methods for evaluating the chemotherapy response of breast cancer patients are currently being explored. The aim of present study was to investigate whether the washout rates...
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Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

Park BL, Kim YJ, Cheong HS, Kim LH, Choi YH, Lee HS, Shin HD

  • KMID: 1115948
  • Exp Mol Med.
  • 2006 Dec;38(6):694-702.
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the...
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