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The role of oxidative stress and hypoxia in renal disease

Honda T, Hirakawa Y, Nangaku M

Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are constantly released during mitochondrial oxygen consumption for energy production. Any imbalance between ROS production and its scavenger system...
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Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes

Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY

Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and...
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Factors that determine the Work Ability Index of street cleaners

Kim JW, Yang S, Chung I, Lee MY

BACKGROUND: Korea has shown a rapid pace of aging and has become an aged society in a shorter period than Western countries. Therefore, it is important that middle-aged workers maintain...
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Comparison of Obesity Related Index and Exercise Capacity Between Center-Based and Home-Based Cardiac Rehabilitation Programs

Park HK, Kim KH, Kim JH, Song MK, Choi IS, Han JY

OBJECTIVE: To compare a center-based cardiac rehabilitation (CR) program with a home-based CR program in terms of improving obesity related index and cardiopulmonary exercise capacity after the completing a phase...
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Effects of Stair Climbing on Blood Pressure, Lipid Profiles, and Physical Fitness

Moon JW, Yoon YS, Lee HJ, Jeong TH, Hwang YH, Kim HS

PURPOSE: The purpose of the study is to identify the effects of worker's stair-climbing on blood pressure, lipid profiles, and physical fitness. METHODS: After recruiting 114 healthy adult women aged 20...
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Respiratory Responses during Exercise in Self-contained Breathing Apparatus among Firefighters and Nonfirefighters

Hostler D, Pendergast DR

BACKGROUND: Firefighters are required to use self-contained breathing apparatus (SCBA), which impairs ventilatory mechanics. We hypothesized that firefighters have elevated arterial COâ‚‚ when using SCBA. METHODS: Firefighters and controls performed a...
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Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation

Hong SW, Lee J, Kwon H, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY

BACKGROUND: Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current...
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Effect of Remote Ischemic Preconditioning on Maximal Exercise Tolerance in Young Adults

Yoon ES, Jae SY

PURPOSE: Remote ischemic preconditioning (RIPC), induced by repeated bouts of ischemia followed by reperfusion of the arm or leg is a noninvasive strategy to protect a target organ against oxidative...
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Patient Blood Management: Obstetrician, Gynecologist's Perspectives

Lee WM

Obstetricians and gynecologists frequently deal with hemorrhage so they should be familiar with management of patient blood management (PBM). We will review to summarize the alternative measures and interventions used...
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Prevalence of Osteopenia According to Physical Fitness in Men: A Cross-Sectional Study

Kim YH, Yoon DH, Kim HK, Song W

BACKGROUND: Bone mineral density (BMD) has been associated with fitness, nutrition, lifestyle, and genetic factors such as sex and race. The aim of this study was to determine whether athletic...
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The Differences in Cardiac Rehabilitation Outcomes by Age in Myocardial Infarction: A Preliminary Study

Kong HH, Bang HJ, Ko JU, Lee GJ

OBJECTIVE: To determine the age-related changes in cardiac rehabilitation (CR) outcomes, which includes hemodynamic and metabolic factors, in patients with myocardial infarction (MI). METHODS: CR was administered for 8 weeks to...
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Relationship Between Post-exercise Heart Rate Recovery and Changing Ratio of Cardiopulmonary Exercise Capacity

Kim JH, Choe YR, Song MK, Choi IS, Han JY

OBJECTIVE: To determine whether heart rate recovery (HRR) following an exercise tolerance test (ETT) is correlated with a changing ratio of peak oxygen consumption (VOâ‚‚) and maximal metabolic equivalents (MET(max)). METHODS:...
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Unobtrusive Estimation of Cardiorespiratory Fitness with Daily Activity in Healthy Young Men

Ahn JW, Hwang SH, Yoon C, Lee J, Kim HC, Yoon HJ

Despite the importance of cardiorespiratory fitness, no practical method exists to estimate maximal oxygen consumption (VOâ‚‚max) without a specific exercise protocol. We developed an estimation model of VOâ‚‚max, using maximal...
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An Analysis between Pre- and Post-exercise of the Respiratory and Metabolic State for the Acute and Subacute Stroke Patients

Kim H, Cheon JH, Lim NN, Cho YK, Lee SH, Lee HK, Lee DY

To evaluate oxygenation and metabolic state of the non-brainstem stroke patients after the moderate intensity exercise using arterial blood gas analysis (ABGA). Fifty-two stroke patients were recruited. All the subjects...
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Comparison of Supervised Hospital-based versus Educated Home-based Exercise Training in Korean Heart Failure Patients

Kim M, Kim MS, Lim SJ, Ahn JM, Kim JJ, Park SJ

BACKGROUND AND OBJECTIVES: Although many clinical trials have shown that exercise training (ET) improves functional capacity and clinical outcomes in heart failure (HF) patients, data comparing supervised hospital-based and educated...
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Cardiopulmonary Exercise Test in Leukemia Patients After Chemotherapy: A Feasibility Study

Kim S, Song IC, Jee S

OBJECTIVE: To explore the feasibility of cardiopulmonary exercise test (CPET) in leukemia patients after chemotherapy. METHODS: Leukemia patients with histologically confirmed hematologic malignancies were reviewed. We evaluated for CPET, between receiving...
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Identification of AMPK activator from twelve pure compounds isolated from Aralia Taibaiensis: implication in antihyperglycemic and hypolipidemic activities

Li Y, Park J, Wu Y, Cui J, Jia N, Xi M, Wen A

The root bark extract of Aralia taibaiensis is used traditionally for the treatment of diabetes mellitus in China. The total saponin extracted from Aralia Taibaiensis (sAT) has effective combined antihyperglycemic...
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miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway

Jeong JH, Cheol Kang Y, Piao Y, Kang S, Pak YK

Mitochondrial deficits or altered expressions of microRNAs are associated with the pathogenesis of various diseases, and microRNA-operated control of mitochondrial activity has been reported. Using a retrovirus-mediated short-hairpin RNA (shRNA)...
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Quality of Life and Physical Ability Changes After Hospital-Based Cardiac Rehabilitation in Patients With Myocardial Infarction

Lee BJ, Go JY, Kim AR, Chun SM, Park M, Yang DH, Park HS, Jung TD

OBJECTIVE: To evaluate the effect of hospital-based cardiac rehabilitation (CR) on quality of life (QOL) and physical ability in patients with myocardial infarction (MI). METHODS: Patients with MI who were referred...
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Influence of Low Peak Respiratory Exchange Ratio on Cardiac Rehabilitation in Patients With Coronary Artery Disease

Kim C, Choi HE, Lee KH, Kim YJ, Lee SJ

OBJECTIVE: To compare and analyze the effects of cardiac rehabilitation (CR) in two groups based on the peak respiratory exchange ratio (RER(peak)) 1.1 values using the exercise tolerance test (ETT)...
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