- Effects of glutamate on dehydroascorbate uptake and Its enhanced vulnerability to the peroxidation in cerebral cortical slices
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Song JH, Shin SH, Chung IM
- KMID: 1121095
- Exp Mol Med.
- 2002 Dec;34(6):419-425.
Pro-oxidant properties of ascorbate have been studied with uses of brain tissues and neuronal cells. Here we address potential mechanism of ascorbate coupling with glutamate to generate oxidative stress,... -
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- Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C
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Kim J, Min G, Bae YS, Min DS
- KMID: 1380203
- Exp Mol Med.
- 2004 Apr;36(2):103-109.
Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-a (PKC-a), and other unidentified proteins in... -
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- Effects of Bevacizumab on Bcl-2 Expression and Apoptosis in Retinal Pigment Epithelial Cells under Oxidative Stress
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Kim S, Kim YJ, Kim NR, Chin HS
- KMID: 2363851
- Korean J Ophthalmol.
- 2015 Dec;29(6):424-432.
- doi: 10.3341/kjo.2015.29.6.424
PURPOSE: To evaluate the effects of bevacizumab on expression of B-cell leukemia/lymphoma (Bcl)-2 and apoptosis in retinal pigment epithelial (RPE) cells under oxidative stress conditions. METHODS: RPE cells were treated with... -
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- Role of Ca2+ influx in the tert-butyl hydroperoxide-induced apoptosis of HepG2 human hepatoblastoma cellse
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Kim JA, Kang YS, Kim YO, Lee SH, Lee YS
- KMID: 1109296
- Exp Mol Med.
- 1998 Sep;30(3):137-144.
Oxidative stress appears to be implicated in the pathogenesis of various diseases including alcoholic liver injury. In this study we investigated the mechanism of apoptosis induced by tert-butyl hydroperoxide (TBHP) in HepG2... -
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- Bisphenol A Impairs Mitochondrial Function in the Liver at Doses below the No Observed Adverse Effect Level
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Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ, Park KS, Jang HC, Park YJ
- KMID: 1421617
- J Korean Med Sci.
- 2012 Jun;27(6):644-652.
- doi: 10.3346/jkms.2012.27.6.644
Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial... -
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- Chlorogenic Acid Supplementation Improves Multifocal Electroretinography in Patients with Retinitis Pigmentosa
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Shin JY, Yu HG
- KMID: 1796924
- J Korean Med Sci.
- 2014 Jan;29(1):117-121.
- doi: 10.3346/jkms.2014.29.1.117
To evaluate the effect of chlorogenic acid supplementation in patients with retinitis pigmentosa, we evaluated objective change in visual function with multifocal electroretinography, along with visual acuity, visual field, standard... -
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- Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H(2)O(2)-induced oxidative stress
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Lee MN, Lee SH, Lee MY, Kim YH, Park JH, Ryu JM, Yun SP, Lee YJ, Kim MO, Park K, Han HJ
- KMID: 1718577
- J Vet Sci.
- 2008 Sep;9(3):247-256.
- doi: 10.4142/jvs.2008.9.3.247
Oxidative stresses induced by reactive oxygen species (ROS) have been shown to be involved in several physiological and pathophysiological processes, such as cell proliferation and differentiation. Steroid hormones can protect... -
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- Effects of Benzo(a)pyrene on the Expression of Heat Shock Proteins, Pro-inflammatory Cytokines and Antioxidant Enzymes in Hepatic Tumors Induced by Rat Hepatoma N1-S1 Cells
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Zheng Z, Park SY, Lee M, Phark S, Won NH, Kang HS, Sul D
- KMID: 1782110
- J Korean Med Sci.
- 2011 Feb;26(2):222-230.
- doi: 10.3346/jkms.2011.26.2.222
Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is easily introduced to humans via consumption of grilled or smoked meat. BaP causes harmful oxidative effects on cell development, growth... -
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- Platinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis
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Kim WK, Kim JC, Park HJ, Sul OJ, Lee MH, Kim JS, Choi HS
- KMID: 1397447
- Exp Mol Med.
- 2012 Jul;44(7):432-439.
Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect against bone loss by... -
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- Effects of Blending Oil of Lavender and Thyme on Oxidative Stress, Immunity, and Skin Condition in Atopic Dermatitis Induced Mice
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Seo YM, Jeong SH
- KMID: 2164378
- J Korean Acad Nurs.
- 2015 Jun;45(3):367-377.
- doi: 10.4040/jkan.2015.45.3.367
PURPOSE: The purpose of this study was to evaluate the effects of essential oil on oxidative stress, immunity, and skin condition in atopic dermatitis (AD) induced mice. METHODS: This study was... -
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- Tempol Attenuates Renal Fibrosis in Mice with Unilateral Ureteral Obstruction: The Role of PI3K-Akt-FoxO3a Signaling
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Yoon HE, Kim SJ, Kim SJ, Chung S, Shin SJ
- KMID: 1789980
- J Korean Med Sci.
- 2014 Feb;29(2):230-237.
- doi: 10.3346/jkms.2014.29.2.230
This study investigated whether tempol, an anti-oxidant, protects against renal injury by modulating phosphatidylinositol 3-kinase (PI3K)-Akt-Forkhead homeobox O (FoxO) signaling. Mice received unilateral ureteral obstruction (UUO) surgery with or without... -
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- Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells
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Lee YJ, Lee SH
- KMID: 1123448
- J Korean Med Sci.
- 2011 Nov;26(11):1474-1482.
- doi: 10.3346/jkms.2011.26.11.1474
Sulforaphane (SFN) is a naturally occurring compound which is known to induce the phase II antioxidant genes via Nrf2 activation, although the underlying mechanism has not been fully elucidated. In... -
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- Arsenic trioxide-induced apoptosis is independent of stress-responsive signaling pathways but sensitive to inhibition of inducible nitric oxide synthase in HepG2 cells
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Kang SH, Song JH, Kang HK, Kang JH, Kim SJ, Kang HW, Lee YK, Park DB
- KMID: 1097255
- Exp Mol Med.
- 2003 Apr;35(2):83-90.
Arsenic trioxide (As2O3) has been found to be remarkably effective in the treatment of patients with acute promyelocytic leukemia (APL). Although evidences for the proapoptotic activity of As2O3 have been... -
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- Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model
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Kim IH, Kim SW, Kim SH, Lee SO, Lee ST, Kim DG, Lee MJ, Park WH
- KMID: 1397449
- Exp Mol Med.
- 2012 Jul;44(7):448-456.
Parthenolide (PT), a sesquiterpene lactone derived from the plant feverfew, has pro-apoptotic activity in a number of cancer cell types. We assessed whether PT induces the apoptosis of hepatic stellate... -
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- Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways
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Zhao H, Liu W, Wang Y, Dai N, Gu J, Yuan Y, Liu X, Bian J, Liu ZP
- KMID: 2344302
- J Vet Sci.
- 2015 Sep;16(3):297-306.
- doi: 10.4142/jvs.2015.16.3.297
Exposure to cadmium (Cd) induces apoptosis in osteoblasts (OBs); however, little information is available regarding the specific mechanisms of Cd-induced primary rat OB apoptosis. In this study, Cd reduced cell... -
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- Ascorbic Acid Alleviates Pancreatic Damage Induced by Dibutyltin Dichloride (DBTC) in Rats
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Lu XL, Song YH, Fu YB, Si JM, Qian KD
- KMID: 1786220
- Yonsei Med J.
- 2007 Dec;48(6):1028-1034.
- doi: 10.3349/ymj.2007.48.6.1028
PURPOSE: Because previous studies have reported depleted antioxidant capacity in patients with chronic pancreatitis (CP), prevention of free radical production has gained importance in antifibrotic treatment strategies for CP.... -
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- Impact of Lysophosphatidylcholine on the Plasminogen Activator System in Cultured Vascular Smooth Muscle Cells
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Yoon BK, Kang YH, Oh WJ, Park K, Lee DY, Choi D, Kim DK, Lee Y, Rhyu MR
- KMID: 2157928
- J Korean Med Sci.
- 2012 Jul;27(7):803-810.
- doi: 10.3346/jkms.2012.27.7.803
The balance between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis. PAI-1 expression increases in atherosclerotic arteries and vascular smooth muscle cells (VSMCs) are one... -
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- Methylmercury Exposure and Health Effects
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Hong YS, Kim YM, Lee KE
- KMID: 1499657
- J Prev Med Public Health.
- 2012 Nov;45(6):353-363.
Methylmercury is a hazardous substance that is of interest with regard to environmental health, as inorganic mercury circulating in the general environment is dissolved into freshwater and seawater, condensed through... -
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- Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy
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Min HS, Cha JJ, Kim K, Kim JE, Ghee JY, Kim H, Lee JE, Han JY, Jeong LS, Cha DR, Kang YS
- KMID: 2468272
- J Korean Med Sci.
- 2016 Sep;31(9):1403-1412.
- doi: 10.3346/jkms.2016.31.9.1403
The concentration of adenosine in the normal kidney increases markedly during renal hypoxia, ischemia, and inflammation. A recent study reported that an A3 adenosine receptor (A3AR) antagonist attenuated the progression... -
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- An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib
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Kwon T, Rho JK, Lee JC, Park YH, Shin HJ, Cho S, Kang YK, Kim BY, Yoon DY, Yu DY
- KMID: 2155657
- Exp Mol Med.
- 2015 May;47(5):e165.
- doi: 10.1038/emm.2015.24
Redox adaptation is an important concept that explains the mechanisms by which cancer cells survive under persistent endogenous oxidative stress and become resistant to certain anticancer agents. To investigate this... -
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