- Rolipram, a Phosphodiesterase 4 Inhibitor, Stimulates Inducible cAMP Early Repressor Expression in Osteoblasts
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Cho ES, Yu JH, Kim MS, Yim M
- KMID: 2158125
- Yonsei Med J.
- 2005 Feb;46(1):149-154.
- doi: 10.3349/ymj.2005.46.1.149
Phosphodiesterase (PDE) 4 inhibitors have been shown to induce the cAMP-mediated signaling pathway by inhibiting cAMP hydrolysis. This study investigated the effect of a PDE4 inhibitor on the expression of... -
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- Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways
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Zhao H, Liu W, Wang Y, Dai N, Gu J, Yuan Y, Liu X, Bian J, Liu ZP
- KMID: 2344302
- J Vet Sci.
- 2015 Sep;16(3):297-306.
- doi: 10.4142/jvs.2015.16.3.297
Exposure to cadmium (Cd) induces apoptosis in osteoblasts (OBs); however, little information is available regarding the specific mechanisms of Cd-induced primary rat OB apoptosis. In this study, Cd reduced cell... -
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- Msx2 mediates the inhibitory action of TNF-alpha on osteoblast differentiation
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Lee HL, Yi T, Woo KM, Ryoo HM, Kim GS, Baek JH
- KMID: 1078359
- Exp Mol Med.
- 2010 Jun;42(6):437-445.
- doi: 10.3858/emm.2010.42.6.045
TNF-alpha, a proinflammatory cytokine, inhibits osteoblast differentiation under diverse inflammatory conditions; however, the underlying mechanisms in terms of the TNF-alpha signaling pathway remain unclear. In this study, we examined the... -
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- Transcriptional activation of insulin-like growth factor binding protein 6 by 17beta-estradiol in SaOS-2 cells
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Zhao YY, Guo L, Zhao XJ, Liu H, Lei T, Ma DJ, Gao XY
- KMID: 1058022
- Exp Mol Med.
- 2009 Jul;41(7):478-486.
- doi: 10.3858/emm.2009.41.7.053
Osteoblasts can synthesize the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs), which may either enhance or attenuate IGF-stimulated bone cell proliferation. Since estrogen induced osteoblastic differentiation and proliferation... -
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