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Establishment of patient-derived three-dimensional organoid culture in renal cell carcinoma

Na JC, Kim JH, Kim SY, Gu YR, Jun DY, Lee HH, Yoon YE, Choi KH, Hong SJ, Han WK

PURPOSE: Renal cell carcinoma is a heterogeneous kidney cancer, and over 403,000 cases were reported worldwide in 2018. Current methods for studying renal cell carcinoma are limited to two-dimensional (2D)...
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Coincidence of Dermal Melanocyte Hamartoma and Becker's Nevus in a Patient with Neurofibromatosis Type 1

Kim YJ, Choi ME, Lee MW, Choi JH, Chang SE

  • KMID: 2470219
  • Korean J Dermatol.
  • 2019 Dec;57(10):632-634.
Dermal melanocytosis is characterized by an increased number of ovoid to elongated melanocytes situated between collagen fibers in the dermis, including blue nevus, Mongolian spots, nevus of Ota and Ito...
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Implication of Porphyromonas gingivalis in colitis and homeostasis of intestinal epithelium

Seo Y, Oh SJ, Ahn JS, Shin YY, Yang JW, Kim HS

Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, has...
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Clinical Implementation of Precision Medicine in Gastric Cancer

Jeon J, Cheong JH

Gastric cancer (GC) is one of the deadliest malignancies in the world. Currently, clinical treatment decisions are mostly made based on the extent of the tumor and its anatomy, such...
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Stem cell-based therapy for inflammatory bowel disease

Shimizu H, Suzuki K, Watanabe M, Okamoto R

Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a...
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Generation of Organotypic Multicellular Spheres by Magnetic Levitation: Model for the Study of Human Hematopoietic Stem Cells Microenvironment

Mejía-Cruz CC, Barreto-Durán E, Pardo-Pérez MA, Jimenez MC, Rincón J, Vanegas K, Rodríguez JL, Jaramillo-Garcia LF, Ulloa JC, Díaz RM, Leal-García E, Pérez-Núñez R, Barreto A, Rodríguez-Pardo VM

BACKGROUND AND OBJECTIVE: The characteristics of human hematopoietic stem cells are conditioned by the microenvironment of the bone marrow, where they interact with other cell populations, such as mesenchymal stem...
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Human ex vivo and in vitro disease models to study food allergy

Hung L, Obernolte , Sewald K, Eiwegger T

Food allergy is a growing global public health concern. As treatment strategies are currently limited to allergen avoidance and emergency interventions, there is an increasing demand for appropriate models of...
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Organoid as a culture system for viral vaccine strains

Hong KJ, Seo SH

Organoid is an in vitro multicellular form mimicking in vivo organ. Its similarity to human organ including cellular organization, molecular expression patterns, as well as genetic signatures enables to study...
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Applications of kidney organoids derived from human pluripotent stem cells

Kim YK, Nam SA, Yang CW

The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing...
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Differentiation of CD31-Positive Vascular Endothelial Cells from Organoid Culture of Dental Pulp Stem Cells

Seo EJ, Park JK, Jeong H, Kang JS, Kim HR, Jang IH

The mesenchymal stem cells (MSCs) that reside in dental tissues hold a great potential for future applications in regenerative dentistry. In this study, we used human dental pulp cells, isolated...
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Organoid culture of bladder cancer cells

Yoshida T, Singh AK, Bishai WR, McConkey D, Bivalacqua TJ

No abstract available.
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The Present and Future of the Cancer Microenvironment Bioprinting

Cho MJ, Chi BH, Kim MJ, Whang YM, Chang IH

Cancer is the tissue complex consisted with heterogeneous cellular compositions, and microenvironmental cues. During the various stages of cancer initiation, development, and metastasis, cell–cell interactions as well as cell-extracellular matrix...
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Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma

Kim S, Chu J, Kim H, Han J

BACKGROUND: Cytologic diagnosis of pulmonary adenoid cystic carcinoma (AdCC) is frequently challenging and differential diagnosis with small cell carcinoma is often difficult. METHODS: Eleven cytologically diagnosed cases of pulmonary AdCC were...
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Alveolar Soft Part Sarcoma of the Uterine Cervix: A Case Report and Review of the Literature

Lee HJ

Alveolar soft part sarcoma (ASPS) of the uterine cervix is a rare malignancy, and 21 cases have been reported the literature from every language (including our case). Herein, we describe...
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A 6-year-old girl with vaginal spotting who was diagnosed with perivascular epithelioid cell neoplasm after vaginoscopic resection

Cho HJ, Lee MK, Kang BM, Kim SH, Chae HD, Kim CH

Perivascular epithelioid cell neoplasm (PEComa) is a rare tumor with unknown malignant potential. We report a case of a 6-year-old child with history of brain tumor (pineoblastoma), who presented with...
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A Case of Organoid Nevus on the Knee

Koh JK, Jung S, Hwang S, Seol JE, Kim H, Sung H, Kim YM, Yoon S, Seo JK

  • KMID: 1802087
  • Korean J Dermatol.
  • 2014 Apr;52(4):283-284.
No abstract available.
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Fibrous hamartoma of infancy: an experience of a single institute

Kang G, Suh YL, Han J, Kwon GY, Lee SK, Seo JM

PURPOSE: Fibrous hamartoma (FH) of infancy is a distinctive fibrous growth that most frequently occurs at birth and during the postnatal period. It is important for clinicians and pathologists to...
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Protruding Type of Fibrous Hamartoma of Infancy

Park O, Lee SM, Won CH, Chang SE, Lee MW, Choi JH, Moon KC, Sung KJ

  • KMID: 2247593
  • Korean J Dermatol.
  • 2011 Apr;49(4):357-359.
Fibrous hamartoma of infancy (FHI) is a rare benign soft tissue tumor that is composed of an organoid pattern of fibrous tissue and primitive mesenchyme and adipose tissue. The majority...
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Becker's Nevus with Underlying Neurofibroma

Kim YJ, Kim MY, Kim HO, Park YM, Kang H

  • KMID: 2302862
  • Korean J Dermatol.
  • 2004 Aug;42(8):1039-1041.
Becker's nevus is a common and acquired focal epidermal melanotic hypermelanosis characterized by a large, unilateral patch showing hyperpigmentation and hypertrichosis on the shoulder, back or chest of a man...
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Primary Carcinoid Tumor of the Uterine Corpus: A Case Report

Hong SR, Kim HS, Shim JU

  • KMID: 2275513
  • Korean J Pathol.
  • 2004 Apr;38(2):109-112.
Carcinoid tumors of the female genital tract are an uncommon clinical finding. This study presents a case of typical carcinoid tumor of the uterine corpus in a 61-year-old woman. The...
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