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Effects of Naloxegol on Gastrointestinal Transit and Colonic Fecal Volume in Healthy Participants Receiving Oxycodone

Olesen AE, Grønlund , Mark EB, Krogh K, Frøkjær , Drewes AM

  • KMID: 2460489
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):602-610.
  • doi: 10.5056/jnm18079
BACKGROUND/AIMS: Opioids cause gastrointestinal (GI) dysmotility, decrease gut secretion, and affect gut sphincters. Symptoms of opioid-induced bowel dysfunction may be alleviated by peripherally acting opioid antagonists like naloxegol, but detailed...
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