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Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

Choi YK, Kang JI, Hyun JW, Koh YS, Kang JH, Hyun CG, Yoon KS, Lee KS, Lee CM, Kim TY, Yoo ES, Kang HK

Alopecia is a distressing condition caused by the dysregulation of anagen, catagen, and telogen in the hair cycle. Dermal papilla cells (DPCs) regulate the hair cycle and play important roles...
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Effect of Evening Primrose Oil on Korean Patients With Mild Atopic Dermatitis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Study

Chung BY, Park SY, Jung MJ, Kim HO, Park CW

BACKGROUND: Atopic dermatitis (AD) is related to a deficiency of delta-6-desaturase, an enzyme responsible for converting linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) as a source of...
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ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells

Kim KJ, Lee J, Park Y, Lee SH

Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. CLA increases growth arrest and apoptosis of human colorectal cancer cells through an isomer-specific manner. ATF3 belongs to...
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Differential Gene Expression in GPR40-Overexpressing Pancreatic beta-cells Treated with Linoleic Acid

Kim IS, Yang SY, Han JH, Jung SH, Park HS, Myung CS

"G protein-coupled receptor 40" (GPR40), a receptor for long-chain fatty acids, mediates the stimulation of glucose-induced insulin secretion. We examined the profiles of differential gene expression in GPR40-activated cells treated...
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Effect of conjugated linoleic acid on compound 48/80-induced pruritus in mice

Kim JW, Kang BT, Kang JH, Yang MP

Pruritus is one of the most important symptoms of allergic inflammatory skin disease. Conjugated linoleic acid (CLA) has been reported to have preventive effects against allergic inflammation. The objective of...
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Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms

Ahn JH, Kim MH, Kwon HJ, Choi SY, Kwon HY

Palmitic acid (PAM), one of the most common saturated fatty acid (SFA) in animals and plants, has been shown to induce apoptosis in exocrine pancreatic AR42J cells. In this study,...
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A Study on the Mechanism of Immunomodulating Effects of Moxifloxacin in Oleic Acid-Induced Acute Lung Injury

Lee YM

BACKGROUND: It was hypothesized that the immunomodulating effects of moxifloxacin contribute to ameliorate oleic acid (OA)-induced acute lung injury (ALI) by suppression of cytosolic phospholipase A2 (cPLA2). This was based...
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Moxifloxacin Alleviates Oleic Acid-provoked Neutrophilic Respiratory Burst in the Rat Lung through the Inhibition of Cytosolic Phospholipase A2

Lee YM

BACKGROUND: According to the notion of the immunoregulatory functions of moxifloxacin (MFX), the effect of MFX on the neutrophilic respiratory burst in conjunction with the expression of cytosolic phospholipase A2...
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Moxifloxacin Ameliorates Oleic Acid-induced Acute Lung Injury by Modulation of Neutrophilic Oxidative Stress in Rats

Kim BY, Lee YM

BACKGROUND: Based on the known immunoregulatory functions of moxifloxacin on phagocytes, the therapeutic effect of moxifloxacin on oleic acid (OA)-induced acute lung injury (ALI) was investigated. METHODS: Moxifloxacin (10 mg/kg) was...
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Chemical Constituents of the Fruiting Body of Xylaria polymorpha

Jang YW, Lee IK, Kim YS, Seok SJ, Yu SH, Yun BS

Xylaria, belonging to the Ascomycotina, is known to produce diverse classes of bioactive substances. In an effort to identify the chemical constituents of the fruiting bodies of Xylaria polymorpha, linoleic...
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Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice

Hue JJ, Lee KN, Jeong JH, Lee SH, Lee YH, Jeong SW, Nam SY, Yun YW, Lee BJ

This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups...
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Diets with corn oil and/or low protein increase acute acetaminophen hepatotoxicity compared to diets with beef tallow in a rat model

Hwang J

  • KMID: 2313383
  • Nutr Res Pract.
  • 2009 Jun;3(2):95-101.
It has been reported that dietary polyunsaturated fats (PUFA) increase liver injury in response to ethanol feeding. We tested the hypothesis that diets rich in linoleic acid (18:2n-6) would affect...
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Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA

Lee Y

Conjugated linoleic acids (CLA) were identified in 1980's, since then it has been intensively studied due to its various beneficial health effects such as anti-inflammatory, anti-atherogenic, anti-carcinogenic and anti-diabetic/obesity effects....
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Effects of Mycophenolic Acid on Oleic Acid- induced Rat Vascular Smooth Muscle Cell Proliferation

Ahn HJ, Park J, Song JS, Ju MK, Kim MS, Ha H, Song KH, Kim YS

  • KMID: 2211048
  • J Korean Surg Soc.
  • 2007 Mar;72(3):171-176.
PURPOSE: Vascular smooth muscle cell (VSMC) proliferation plays an important role in the development and progression of chronic allograft vasculopathy. Mycophenolic acid (MPA) inhibits various mesenchymal cell proliferation, and reactive...
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Effect of Topically Applied Multi-lamellar Emulsion Containing Linoleic Acid on Experimentally Induced Comedones

Lee SE, Jeong SK, Youm JK, Lee SH

  • KMID: 2116319
  • Korean J Dermatol.
  • 2007 Mar;45(3):249-254.
BACKGROUND: Disturbed keratinization of the follicular infundibulum is the earliest change in comedo formation. The relative decrease in linoleic acid in the sebum could be responsible, in part, for this...
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Fatty Acids Composition in Breast Milk and Its Relationship with Infant Body Weight Gain

Han YS, Park MJ, Kim SH, Ahn JH, Jin HS

  • KMID: 1568747
  • J Korean Soc Pediatr Endocrinol.
  • 2004 Dec;9(2):173-178.
PURPOSE:Recent studies proposed that polyunsaturated fatty acids (PUFA) of the omega6 series (linoleic acid, LA) compared to the omega 3 series (linolenic acid, LNA) may be a potent promoters of...
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Effect of CLA (Conjugated Linoleic Acid) on the Anti-Atherosclerotic Factors in Human Hepatoma HepG2 Cells

Oh H, Mun H, Lee M

  • KMID: 2269778
  • Korean J Nutr.
  • 2004 Apr;37(3):182-192.
Conjugated linoleic acid (CLA) is the mixture of positional and geometric isomers of linoleic acid (LA), which is found abundantly in dairy products and meats. This study was performed to...
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Arctii Fructus is a Prominent Dietary Source of Linoleic Acid for Reversing Epidermal Hyperproliferation of Guinea Pigs

Seong K, Kim J, Lee J, Park S, Cho Y

  • KMID: 1618394
  • Korean J Nutr.
  • 2003 Oct;36(8):819-827.
Linoleic acid [LA; 18: 2 (n-6)] is the most abundant polyunsaturated fatty acid in human skin. The exclusion of LA from diet induces epidermal hyperproliferation, which is reversible by the...
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Effects of Conjugated Linoleic Acid (CLA) on Matrix Metalloproteinase (MMP) Activity and Cell Motility in Human Colon Cancer Cell Lines

Seol SM, Bang MH, Choi OS, Yoon JH, Kim WK

  • KMID: 2269652
  • Korean J Nutr.
  • 2003 Apr;36(3):280-286.
Conjugated linoleic acid (CLA) consists of several geometric isomers of linoleic acid. CLA is found in foods derived from ruminants and exhibits strong anticarcinogenic effects in a variety of animal...
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Study of the Mechanism for the Growth Inhibitory Effects of Conjugated Linoleic Acid on Caco-2 Colon Cancer Cells

Oh EJ, Oh YS, Lee HS, Park HS, Yoon JH

  • KMID: 2269651
  • Korean J Nutr.
  • 2003 Apr;36(3):270-279.
Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid (LA) and exhibits anticarcinogenic activity in a variety of animal models. We have previously observed...
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