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Optimal dose of dexmedetomidine for sedation during spinal anesthesia

Ok HG, Baek SH, Baik SW, Kim HK, Shin SW, Kim KH

BACKGROUND: Sedation in spinal anesthesia can reduce patient's anxiety and discomfort. Dexmedetomidine has a sedative, hypnotic, analgesic, and minimal respiratory depression effect. However, use of the dexmedetomidine is associated with...
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Can oliceridine (TRV130), an ideal novel µ receptor G protein pathway selective (µ-GPS) modulator, provide analgesia without opioid-related adverse reactions?

Ok HG, Kim SY, Lee SJ, Kim TK, Huh BK, Kim KH

All drugs have both favorable therapeutic and untoward adverse effects. Conventional opioid analgesics possess both analgesia and adverse reactions, such as nausea, vomiting, and respiratory depression. The opioid ligand binds...
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Extraspinal Percutaneous Osteoplasty for the Treatment of Painful Bony Metastasis

Lee JH, Kim SY, Ok HG, Kim TK, Kim KH

BACKGROUND: Extraspinal percutaneous osteoplasties (POPs) are novel techniques for the treatment of painful bony metastasis, which is often the cause of both persistent and incidental breakthrough pain. This retrospective study...
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Can denosumab be a substitute, competitor, or complement to bisphosphonates?

Kim SY, Ok HG, Birkenmaier C, Kim KH

Osteoblasts, originating from mesenchymal cells, make the receptor activator of the nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in order to control differentiation of activated osteoclasts, originating from...
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