- Toll-like receptor 4/nuclear factor-kappa B pathway is involved in radicular pain by encouraging spinal microglia activation and inflammatory response in a rat model of lumbar disc herniation
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Zhu L, Huang Y, Hu Y, Tang Q, Zhong Y
- KMID: 2510311
- Korean J Pain.
- 2021 Jan;34(1):47-57.
- doi: 10.3344/kjp.2021.34.1.47
Background: Lumbar disc herniation (LDH) is a common cause of radicular pain, but the mechanism is not clear. In this study, we investigated the engagement of toll-like receptor 4 (TLR4)... -
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- Evaluation of Bone Marrow-derived Stem Cells and Adipose-derived Stem Cells Co-cultured on Human Nucleus Pulposus Cells: A Pilot Study
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Yoon SH, Kim DH, Cho S, Kim KJ
- KMID: 2523119
- Korean J Neurotrauma.
- 2020 Oct;16(2):138-146.
- doi: 10.13004/kjnt.2020.16.e36
Objective: We aimed to determine whether bone marrow-derived mesenchymal stem cells (BDMSCs) effectively attenuate the degeneration of human nucleus pulposus cells (NPCs). Methods: Four NPC lines were obtained from 3 subjects... -
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- Effect of Conditioned Medium from Human Umbilical Cord-Derived Mesenchymal Stromal Cells on Rejuvenation of Nucleus Pulposus Derived Stem/Progenitor Cells from Degenerated Intervertebral Disc
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Zeng X, Lin J, Wu H, Yu J, Tu M, Cheang LH, Zhang J
- KMID: 2504338
- Int J Stem Cells.
- 2020 Jul;13(2):257-267.
- doi: 10.15283/ijsc20027
Background and Objectives: Mesenchymal stromal cells (MSCs)-based treatment for degeneration of intervertebral disc (IVD) has been proposed recently. We here addressed whether MSC secreted factors can rejuvenate nucleus pulposus- derived... -
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- Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review
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Volleman T, Schol J, Morita K, Sakai D, Watanabe M
- KMID: 2501530
- Neurospine.
- 2020 Mar;17(1):19-35.
- doi: 10.14245/ns.2040040.020
Low back pain remains a highly prevalent pathology engendering a tremendous socioeconomic burden. Low back pain is generally associated with intervertebral disc (IVD) degeneration, a process involving the deterioration of... -
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- Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies
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Devraj VM, Vemuri SK, Banala RR, Gunda SK, AV GR, GPV S
- KMID: 2467417
- Asian Spine J.
- 2019 Dec;13(6):875-889.
- doi: 10.31616/asj.2019.0073
STUDY DESIGN: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG). PURPOSE: To evaluate the efficacy of natural flavonoids as therapeutic drugs against... -
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- Comparison of Transforming Growth Factor-Beta1 and Lovastatin on Differentiating Mesenchymal Stem Cells toward Nucleus Pulposus-like Phenotype: An In Vitro Cell Culture Study
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Yang SH, Yang KC, Chen CW, Huang TC, Sun YH, Hu MH
- KMID: 2461998
- Asian Spine J.
- 2019 Oct;13(5):705-712.
- doi: 10.31616/asj.2018.0257
STUDY DESIGN: In Vitro cell culture study. PURPOSE: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus... -
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- Delayed-Onset Leg Weakness Caused by Posterior Migration of a Herniated Disc to the Thecal Sac Mimicking Epidural Hematoma in a Flexion-Distraction Injury of the Lumbar Spine: A Case Report
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Jeon CH, Chung NS, Lee HD, Chung HW
- KMID: 2459760
- J Korean Soc Spine Surg.
- 2019 Sep;26(3):105-110.
- doi: 10.4184/jkss.2019.26.3.105
STUDY DESIGN: Case report. OBJECTIVES: To document the first known case of posterior migration of a herniated disc in a lumbar flexion-distraction injury. SUMMARY OF LITERATURE REVIEW: Lumbar disc herniation is sometimes... -
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- Quantitative Predictive Imaging Biomarkers of Lumbar Intervertebral Disc Degeneration
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Vadapalli , Mulukutla , Vadapalli , Vedula RR
- KMID: 2455641
- Asian Spine J.
- 2019 Aug;13(4):527-534.
- doi: 10.31616/asj.2018.0166
STUDY DESIGN: Observational comparative study. PURPOSE: To compare fractional anisotropy (FA) maps with T2 values of the nucleus pulposus (NP) and annulus fibrosus (AF) of intervertebral discs in healthy volunteers and... -
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- Variations in Matrix Metalloproteinase Expression by Disc Location in Patients with Sequestrated Lumbar Disc Herniation
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Kim YY, Park D, Rhyu KW
- KMID: 2150543
- J Korean Soc Spine Surg.
- 2015 Dec;22(4):160-164.
- doi: 10.4184/jkss.2015.22.4.160
STUDY DESIGN: In vivo study OBJECTIVES: To evaluate variations in matrix metalloproteinase (MMP) expression levels according to the disc location in patients with sequestrated lumbar disc herniation. SUMMARY OF LITERATURE REVIEW: MMPs... -
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- Effect of High Glucose on Stress-Induced Senescence of Nucleus Pulposus Cells of Adult Rats
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Kong JG, Park JB, Lee D, Park EY
- KMID: 2270155
- Asian Spine J.
- 2015 Apr;9(2):155-161.
- doi: 10.4184/asj.2015.9.2.155
STUDY DESIGN: In vitro cell culture model. PURPOSE: We investigated the effect of diabetes mellitus (DM) on senescence of adult nucleus pulposus (NP) cells. OVERVIEW OF LITERATURE: DM is a major public... -
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- Evaluation of Behavior and Expression of Receptor Activator of Nuclear Factor-Kappa B Ligand in Dorsal Root Ganglia after Sciatic Nerve Compression and Application of Nucleus Pulposus in Rats
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Matsuyama , Sakuma Y, Suzuki M, Orita S, Yamauchi K, Inoue G, Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Kubota G, Oikawa Y, Inage K, Sainoh T, Sato J, Nakamura J, Toyone T, Takahashi , Ohtori S
- KMID: 2270236
- Asian Spine J.
- 2014 Oct;8(5):557-564.
- doi: 10.4184/asj.2014.8.5.557
STUDY DESIGN: Experimental animal study. PURPOSE: To evaluate pain-related behavior and changes in nuclear factor-kappa B (NF-kB), receptor activator of NF-kB (RANK), and ligand (RANKL) in dorsal root ganglia (DRG) after... -
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- Regulatory Role of Hypoxia Inducible Factor in the Biological Behavior of Nucleus Pulposus Cells
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Li H, Liang CZ, Chen QX
- KMID: 2158211
- Yonsei Med J.
- 2013 Jul;54(4):807-812.
- doi: 10.3349/ymj.2013.54.4.807
Intervertebral disc (IVD) degeneration is implicated as a major cause of low back pain. The alternated phenotypes, reduced cell survival, decreased metabolic activity, loss of matrix production and dystrophic mineralization... -
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- Ex Vivo Observation of Human Nucleus Pulposus Chondrocytes Isolated From Degenerated Intervertebral Discs
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Wang F, Wu XT, Zhuang SY, Wang YT, Hong X, Zhu L, Bao JP
- KMID: 1444938
- Asian Spine J.
- 2011 Jun;5(2):73-81.
- doi: 10.4184/asj.2011.5.2.73
STUDY DESIGN: We performed an ex vivo study to observe cell morphology and viability of human nucleus pulposus (NP) chondrocytes isolated from degenerated intervertebral discs (IVD). PURPOSE: To better understand the... -
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- Effects of Mechanical Stimulation and Scaffolds for Nucleus Pulposus Replacement of Intervertebral Disc
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Ha SH, Kim DH, Shin JW, Gwak HC, Choi JS
- KMID: 2199044
- J Korean Orthop Res Soc.
- 2009 Dec;12(2):45-52.
PURPOSE: In this study, we investigated the potential of injectable hydrogel scaffolds for the regeneration of nucleus pulposus. MATERIALS AND METHODS: We prepared injectable hydrogels [Chitosan-Pluronic (CP), CP/Osteogenic Protein-1 (CP/OP-1), CP/Gly-Arg-Gly-Asp-Ser... -
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- Transforaminal Selective Nerve Root Blocks for Treating Single Lumbosacral Radiculopathy: The Short-term Outcome and Efficiency
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Kim SB, Jeon TS, Park WK, Jo SK, Kim YS, Hwang CM
- KMID: 2186288
- J Korean Orthop Assoc.
- 2009 Dec;44(6):619-626.
- doi: 10.4055/jkoa.2009.44.6.619
PURPOSE: We wanted to determine the clinic usefulness of selective nerve root block for treating lumbosacral radiculopathy that's due to a herniated nucleus pulposus (HNP) or foraminal stenosis (FS) by... -
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- The Long-Lasting Pattern of the Neuropathic Radicular Pain in An Autologous Nucleus Pulposus Model of Rat
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Kim WR, Ahn SH, Cho YW, Cho HK, Kim HS, Kim SJ, Seo JM
- KMID: 2325478
- J Korean Acad Rehabil Med.
- 2009 Aug;33(4):477-482.
OBJECTIVE: To observe the long-lasting changes of pain progression with time course in an autologous nucleus pulposus model of rat. METHOD: The subjects were 25 Sprague-Dawley (Sprague- Dawley, 250 gm) male... -
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- Expression of Growth Factors and Cytokines in Patients withDegenerated Disc Disease and Herniated Nucleus Pulposus
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Moon CS, Lee SC, Jung WW, Sul D, Hong YK, Kim HS, Wang J, Lee SH
- KMID: 2325404
- J Korean Acad Rehabil Med.
- 2009 Jun;33(3):304-308.
OBJECTIVE: To investigate the expression of cytokines and growth factors in disc specimens obtained from small numbers of patients with herniated nucleus pulposus (HNP) and degenerated disc disease (DDD). METHOD: A... -
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- Lumbar Discectomy Using Tubular Retractor and Microendoscopy
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Ki SC, Choi YS, Kim KS, Kuk WJ
- KMID: 2209630
- J Korean Soc Spine Surg.
- 2008 Dec;15(4):265-271.
- doi: 10.4184/jkss.2008.15.4.265
STUDY DESIGN: Retrospective study OBJECTIVES: To compare the surgical results of microendoscopic discectomy using a tubular retractor with those of a conventional discectomy for lumbar herniated nucleus pulposus. SUMMARY OF LITERATURE REVIEW:... -
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- Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
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Kim KW, Ha KY, Lee JS, Na KH, Kim YY, Woo YK
- KMID: 1721127
- Asian Spine J.
- 2008 Jun;2(1):1-8.
- doi: 10.4184/asj.2008.2.1.1
STUDY DESIGN: Senescence-related markers were assessed in surgically obtained human nucleus pulposus (NP) specimens. PURPOSE: To demonstrate the mechanism and signaling pathway involved in the senescence of NP chondrocytes. OVERVIEW... -
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- The Effective Steroid Dose of Caudal Epidural Injection with Unilateral Epidural Catheter Position in Patients with Symptomatic Herniated Nucleus Purposus
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Shin YH, Kim TH, Lee SJ, Lee CJ, Sim WS, Gwak MS, Kim CS, Hahm TS, Kim MH, Cho HS, Chung IS, Lee BD
- KMID: 1763282
- Korean J Anesthesiol.
- 2008 Apr;54(4):427-430.
- doi: 10.4097/kjae.2008.54.4.427
BACKGROUND: The epidural steroid injection is commonly used in the management of chronic low back pain and radiating pain. We compared the efficacy of 40, 60, and 80 mg of... -
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