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Toll-like receptor 4/nuclear factor-kappa B pathway is involved in radicular pain by encouraging spinal microglia activation and inflammatory response in a rat model of lumbar disc herniation

Zhu L, Huang Y, Hu Y, Tang Q, Zhong Y

Background: Lumbar disc herniation (LDH) is a common cause of radicular pain, but the mechanism is not clear. In this study, we investigated the engagement of toll-like receptor 4 (TLR4)...
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Effect of Conditioned Medium from Human Umbilical Cord-Derived Mesenchymal Stromal Cells on Rejuvenation of Nucleus Pulposus Derived Stem/Progenitor Cells from Degenerated Intervertebral Disc

Zeng X, Lin J, Wu H, Yu J, Tu M, Cheang LH, Zhang J

Background and Objectives: Mesenchymal stromal cells (MSCs)-based treatment for degeneration of intervertebral disc (IVD) has been proposed recently. We here addressed whether MSC secreted factors can rejuvenate nucleus pulposus- derived...
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Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review

Volleman T, Schol J, Morita K, Sakai D, Watanabe M

Low back pain remains a highly prevalent pathology engendering a tremendous socioeconomic burden. Low back pain is generally associated with intervertebral disc (IVD) degeneration, a process involving the deterioration of...
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Delayed-Onset Leg Weakness Caused by Posterior Migration of a Herniated Disc to the Thecal Sac Mimicking Epidural Hematoma in a Flexion-Distraction Injury of the Lumbar Spine: A Case Report

Jeon CH, Chung NS, Lee HD, Chung HW

STUDY DESIGN: Case report. OBJECTIVES: To document the first known case of posterior migration of a herniated disc in a lumbar flexion-distraction injury. SUMMARY OF LITERATURE REVIEW: Lumbar disc herniation is sometimes...
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Quantitative Predictive Imaging Biomarkers of Lumbar Intervertebral Disc Degeneration

Vadapalli , Mulukutla , Vadapalli , Vedula RR

STUDY DESIGN: Observational comparative study. PURPOSE: To compare fractional anisotropy (FA) maps with T2 values of the nucleus pulposus (NP) and annulus fibrosus (AF) of intervertebral discs in healthy volunteers and...
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Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies

Devraj VM, Vemuri SK, Banala RR, Gunda SK, AV GR, GPV S

STUDY DESIGN: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG). PURPOSE: To evaluate the efficacy of natural flavonoids as therapeutic drugs against...
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Comparison of Transforming Growth Factor-Beta1 and Lovastatin on Differentiating Mesenchymal Stem Cells toward Nucleus Pulposus-like Phenotype: An In Vitro Cell Culture Study

Yang SH, Yang KC, Chen CW, Huang TC, Sun YH, Hu MH

STUDY DESIGN: In Vitro cell culture study. PURPOSE: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus...
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Effect of High Glucose on Stress-Induced Senescence of Nucleus Pulposus Cells of Adult Rats

Kong JG, Park JB, Lee D, Park EY

STUDY DESIGN: In vitro cell culture model. PURPOSE: We investigated the effect of diabetes mellitus (DM) on senescence of adult nucleus pulposus (NP) cells. OVERVIEW OF LITERATURE: DM is a major public...
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Variations in Matrix Metalloproteinase Expression by Disc Location in Patients with Sequestrated Lumbar Disc Herniation

Kim YY, Park D, Rhyu KW

STUDY DESIGN: In vivo study OBJECTIVES: To evaluate variations in matrix metalloproteinase (MMP) expression levels according to the disc location in patients with sequestrated lumbar disc herniation. SUMMARY OF LITERATURE REVIEW: MMPs...
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Evaluation of Behavior and Expression of Receptor Activator of Nuclear Factor-Kappa B Ligand in Dorsal Root Ganglia after Sciatic Nerve Compression and Application of Nucleus Pulposus in Rats

Matsuyama , Sakuma Y, Suzuki M, Orita S, Yamauchi K, Inoue G, Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Kubota G, Oikawa Y, Inage K, Sainoh T, Sato J, Nakamura J, Toyone T, Takahashi , Ohtori S

STUDY DESIGN: Experimental animal study. PURPOSE: To evaluate pain-related behavior and changes in nuclear factor-kappa B (NF-kB), receptor activator of NF-kB (RANK), and ligand (RANKL) in dorsal root ganglia (DRG) after...
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Regulatory Role of Hypoxia Inducible Factor in the Biological Behavior of Nucleus Pulposus Cells

Li H, Liang CZ, Chen QX

Intervertebral disc (IVD) degeneration is implicated as a major cause of low back pain. The alternated phenotypes, reduced cell survival, decreased metabolic activity, loss of matrix production and dystrophic mineralization...
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Ex Vivo Observation of Human Nucleus Pulposus Chondrocytes Isolated From Degenerated Intervertebral Discs

Wang F, Wu XT, Zhuang SY, Wang YT, Hong X, Zhu L, Bao JP

STUDY DESIGN: We performed an ex vivo study to observe cell morphology and viability of human nucleus pulposus (NP) chondrocytes isolated from degenerated intervertebral discs (IVD). PURPOSE: To better understand the...
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The Long-Lasting Pattern of the Neuropathic Radicular Pain in An Autologous Nucleus Pulposus Model of Rat

Kim WR, Ahn SH, Cho YW, Cho HK, Kim HS, Kim SJ, Seo JM

  • KMID: 2325478
  • J Korean Acad Rehabil Med.
  • 2009 Aug;33(4):477-482.
OBJECTIVE: To observe the long-lasting changes of pain progression with time course in an autologous nucleus pulposus model of rat. METHOD: The subjects were 25 Sprague-Dawley (Sprague- Dawley, 250 gm) male...
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Expression of Growth Factors and Cytokines in Patients withDegenerated Disc Disease and Herniated Nucleus Pulposus

Moon CS, Lee SC, Jung WW, Sul D, Hong YK, Kim HS, Wang J, Lee SH

  • KMID: 2325404
  • J Korean Acad Rehabil Med.
  • 2009 Jun;33(3):304-308.
OBJECTIVE: To investigate the expression of cytokines and growth factors in disc specimens obtained from small numbers of patients with herniated nucleus pulposus (HNP) and degenerated disc disease (DDD). METHOD: A...
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Effects of Mechanical Stimulation and Scaffolds for Nucleus Pulposus Replacement of Intervertebral Disc

Ha SH, Kim DH, Shin JW, Gwak HC, Choi JS

  • KMID: 2199044
  • J Korean Orthop Res Soc.
  • 2009 Dec;12(2):45-52.
PURPOSE: In this study, we investigated the potential of injectable hydrogel scaffolds for the regeneration of nucleus pulposus. MATERIALS AND METHODS: We prepared injectable hydrogels [Chitosan-Pluronic (CP), CP/Osteogenic Protein-1 (CP/OP-1), CP/Gly-Arg-Gly-Asp-Ser...
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Transforaminal Selective Nerve Root Blocks for Treating Single Lumbosacral Radiculopathy: The Short-term Outcome and Efficiency

Kim SB, Jeon TS, Park WK, Jo SK, Kim YS, Hwang CM

PURPOSE: We wanted to determine the clinic usefulness of selective nerve root block for treating lumbosacral radiculopathy that's due to a herniated nucleus pulposus (HNP) or foraminal stenosis (FS) by...
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Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs

Kim KW, Ha KY, Lee JS, Na KH, Kim YY, Woo YK

STUDY DESIGN: Senescence-related markers were assessed in surgically obtained human nucleus pulposus (NP) specimens. PURPOSE: To demonstrate the mechanism and signaling pathway involved in the senescence of NP chondrocytes. OVERVIEW...
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The Effective Steroid Dose of Caudal Epidural Injection with Unilateral Epidural Catheter Position in Patients with Symptomatic Herniated Nucleus Purposus

Shin YH, Kim TH, Lee SJ, Lee CJ, Sim WS, Gwak MS, Kim CS, Hahm TS, Kim MH, Cho HS, Chung IS, Lee BD

BACKGROUND: The epidural steroid injection is commonly used in the management of chronic low back pain and radiating pain. We compared the efficacy of 40, 60, and 80 mg of...
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Lumbar Discectomy Using Tubular Retractor and Microendoscopy

Ki SC, Choi YS, Kim KS, Kuk WJ

STUDY DESIGN: Retrospective study OBJECTIVES: To compare the surgical results of microendoscopic discectomy using a tubular retractor with those of a conventional discectomy for lumbar herniated nucleus pulposus. SUMMARY OF LITERATURE REVIEW:...
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The Study of the Regeneration of Nucleus Pulposususing Nanofiber-based Scaffold : In Vitro and Animal Study

Choi JS, An KC, Jang JH, Shin JW, Kim YJ

  • KMID: 2398744
  • J Korean Orthop Assoc.
  • 2006 Aug;41(4):721-729.
PURPOSE: To investigate the potential of nucleus pulposus (NP) regeneration with a nanofiber-based scaffold inserted in the degenerative disc. MATERIALS AND METHODS: A nanofiber scaffold was fabricated using an electrospinning technique....
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