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XperCT-guided Intra-cisterna Magna Injection of Streptozotocin for Establishing an Alzheimer’s Disease Model Using the Cynomolgus Monkey (Macaca fascicularis)

Park J, Won J, Jeon CY, Lim KS, Choi WS, Park Sh, Seo J, Cho J, Seong JB, Yeo HG, Kim K, Kim YG, Kim M, Yi KS, Lee Y

  • KMID: 2537960
  • Exp Neurobiol.
  • 2022 Dec;31(6):409-418.
  • doi: 10.5607/en22027
Till date, researchers have been developing animal models of Alzheimer’s disease (AD) in various species to understand the pathological characterization and molecular mechanistic pathways associated with this condition in humans...
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Sudden cardiac death as a naturally-occurring ventricular hypertrophy in Macaca fascicularis

Yeo HG, Park J, Kim HK, Lee JM, Koo BS, An JH, Jeon CY, An YJ, Choi WS, Park SH, Seo J, Won J, Kim K, Cho J, Kim YG, Kim M, Seong JB, Huh JW, Kim SS, Lee Y, Lim KS

Naturally occurring left ventricular hyperplasia is a rare but lethal disease. There are very few reports of this cardiac disease in captive nonhuman primates. In a colony of Macaca mulatta...
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Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson’s Disease

Seo Jc, Won Jy, Kim Kw, Park Jh, Yeo HG, Kim YG, Baek SH, Lee H, Jeon CY, Choi WS, Lee S, Kim KJ, Park SH, Son Yh, Jeong KJ, Lim KS, Kang P, Lee HY, Son HC, Huh JW, Kim YH, Lee DS, Lee SR, Choi JW, Lee Yj

  • KMID: 2508474
  • Exp Neurobiol.
  • 2020 Oct;29(5):376-388.
  • doi: 10.5607/en20040
ymptoms of Parkinson’s disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an...
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Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Koo BS, Lee DH, Kang P, Jeong KJ, Lee S, Kim K, Lee Y, Huh JW, Kim YH, Park SJ, Jin YB, Kim SU, Kim JS, Son Y, Lee SR

Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematologic and...
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Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling

Park J, Seo J, Won J, Yeo HG, Ahn YJ, Kim K, Jin YB, Koo BS, Lim KS, Jeong KJ, Kang P, Lee HY, Baek SH, Jeon CY, Hong JJ, Huh JW, Kim YH, Park SJ, Kim SU, Lee DS, Lee SR, Lee Y

Mitochondria continuously fuse and divide to maintain homeostasis. An impairment in the balance between the fusion and fission processes can trigger mitochondrial dysfunction. Accumulating evidence suggests that mitochondrial dysfunction is...
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Decoding Saccadic Directions Using Epidural ECoG in Non-Human Primates

Lee J, Choi H, Lee S, Cho BH, Ahn KH, Kim IY, Lee KM, Jang DP

A brain-computer interface (BCI) can be used to restore some communication as an alternative interface for patients suffering from locked-in syndrome. However, most BCI systems are based on SSVEP, P300,...
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Increase in Anti-Gal IgM Level is Associated With Early Graft Failure in Intraportal Porcine Islet Xenotransplantation

Kang HJ, Lee H, Park EM, Kim JM, Shin JS, Kim JS, Park CG, Kim SJ

BACKGROUND: Anti-Gal is a major antibody induced in non-human primates (NHPs) after xenotransplantation. To understand the mechanism of graft rejection, we investigated the association between anti-Gal responses and graft failure...
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Cryptosporidium spp., Giardia intestinalis, and Enterocytozoon bieneusi in Captive Non-Human Primates in Qinling Mountains

Du SZ, Zhao GH, Shao JF, Fang YQ, Tian GR, Zhang LX, Wang RJ, Wang HY, Qi M, Yu SK

Non-human primates (NHPs) are confirmed as reservoirs of Cryptosporidium spp., Giardia intestinalis, and Enterocytozoon bieneusi. In this study, 197 fresh fecal samples from 8 NHP species in Qinling Mountains, northwestern...
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Milk Transfer and Toxicokinetics of Valproic Acid in Lactating Cynomolgus Monkeys

Lee JH, Yu WJ, Jeong EJ, Chung MK

  • KMID: 2317816
  • Toxicol Res.
  • 2013 Mar;29(1):53-60.
Studies on milk transfer of drugs in non-human primates (NHPs) are among the crucial components in the assessment of peri- and postnatal toxicity because of the similarity between NHPs and...
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Codelivery of IL-7 Augments Multigenic HCV DNA Vaccine-induced Antibody as well as Broad T Cell Responses in Cynomolgus Monkeys

Park SH, Song MY, Nam HJ, Im SJ, Sung YC

BACKGROUND: A crucial limitation of DNA vaccines is its weak immunogenicity, especially in terms of eliciting antibody responses in non-human primates or humans; therefore, it is essential to enhance immune...
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Establishment of a Research and Assessment System Using High Quality Non-Human Primates

Hyun BH, Kang BC, Kim CK, Kim HS, Suh JG, Cho F

At present, eight non-human primate research facilities exist in Korea to examine the validity and safety of new bio-products, and to generate model animal systems using primates of low health...
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Experimental Pancreas Islet Isolation in Non- Human Primate

Kim SC, Han DJ, Hering BJ

  • KMID: 2198970
  • J Korean Soc Transplant.
  • 2001 Dec;15(2):142-146.
Transplantation of the pancreas islet cell has been demonstrated to be able to cure for type I diabetes. It can offer not only discontinuing of insulin but also preventing of...
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