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Use of progesterone as a preventive medicine and nifedipine as a treatment of preterm labor

Kim YS

Preterm birth is a major cause of neonatal morbidity and mortality, and occurs in 5% to 15% of all pregnancies. Therefore, its prevention is a major opportunity to reduce medical...
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Bier Spots: Low-dose Nifedipine Therapy

Jeong HB, Shin YB, Kim CY

  • KMID: 2436662
  • Korean J Dermatol.
  • 2018 Feb;56(2):158-159.
No abstract available.
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Relaxant and anti-inflammatory effect of two thalidomide analogs as PDE-4 inhibitors in pregnant rat uterus

Muñoz-Pérez VM, Fernández-Martínez E, Ponce-Monter H, Ortiz MI

The aim of this study was to evaluate the relaxant and anti-inflammatory effects of two thalidomide analogs as phosphodiesterase-4 (PDE-4) inhibitors in pregnant rat uterus. Uteri from Wistar female rats...
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Preventive effects of imperatorin on perfluorohexanesulfonate-induced neuronal apoptosis via inhibition of intracellular calcium-mediated ERK pathway

Lee E, Choi SY, Yang JH, Lee YJ

Early life neuronal exposure to environmental toxicants has been suggested to be an important etiology of neurodegenerative disease development. Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds, is widely distributed...
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cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria

Peng LQ, Li P, Zhang QL, Hong L, Liu LP, Cui X, Cui BR

Adenosine 3',5'-cyclic monophosphate (cAMP) participates in the regulation of numerous cellular functions, including the Na(+)-K(+)-ATPase (sodium pump). Ouabain, used in the treatment of several heart diseases, is known to increase...
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A Case of Pleural Effusion and Pulmonary Edema Caused by Calcium Channel Blockers in a Patient of Systemic Hypertension

Kim DK, Kim JS, Yi HR, Choi IZ, Ahn HS, Cho WH

Calcium channel blockers (CCBs) are very popular drugs to lower blood pressure (BP) without significant side effects. A 72-year-old man admitted for uncontrolled hypertension. He had history of hypertension, atrial...
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Bupivacaine-induced Vasodilation Is Mediated by Decreased Calcium Sensitization in Isolated Endothelium-denuded Rat Aortas Precontracted with Phenylephrine

Ok SH, Bae SI, Kwon SC, Park JC, Kim WC, Park KE, Shin IW, Lee HK, Chung YK, Choi MJ, Sohn JT

BACKGROUND: A toxic dose of bupivacaine produces vasodilation in isolated aortas. The goal of this in vitro study was to investigate the cellular mechanism associated with bupivacaine-induced vasodilation in isolated...
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Role of calcium channels responsible for phenylephrine-induced contraction in rat aorta 3 days after acute myocardial infarction

Kim JE, Choi BK, Choi JY, Ryu T, Roh WS, Song SY

BACKGROUND: Phenylephrine (PE) produces tonic contraction through involvement of various calcium channels such as store-operated calcium channels (SOCCs) and voltage-operated calcium channels (VOCCs). However, the relative contribution of each calcium...
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Mepivacaine-induced intracellular calcium increase appears to be mediated primarily by calcium influx in rat aorta without endothelium

Ok SH, Kwon SC, Kang S, Choi MJ, Sohn JT

BACKGROUND: Mepivacaine induces contraction or decreased blood flow both in vivo and in vitro. Vasoconstriction is associated with an increase in the intracellular calcium concentration ([Ca2+]i). However, the mechanism responsible...
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Red Liriope platyphylla stimulated the insulin secretion through the regulation of calcium concentration in rat insulinoma cells and animal models

Lee HR, Kim JE, Lee YJ, Kwak MH, Im DS, Hwang DY

The aim of this study was to investigate the effects of Red L. platyphylla (RLP) on calcium and glucose levels during insulin secretion. To achieve this, alteration of insulin and...
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Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase

Sung DJ, Noh HJ, Kim JG, Park SW, Kim B, Cho H, Bae YM

  • KMID: 2154286
  • Exp Mol Med.
  • 2013 Dec;45(12):e67.
Serotonin (5-hydroxytryptamine (5-HT)) is a neurotransmitter that regulates a variety of functions in the nervous, gastrointestinal and cardiovascular systems. Despite such importance, 5-HT signaling pathways are not entirely clear. We...
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A Case of Severe Coronary Spasm Associated with 5-Fluorouracil Chemotherapy

Kim SM, Kwak CH, Lee B, Kim SB, Sir JJ, Cho WH, Choi SK

Cardiotoxicity associated with 5-fluorouracil (FU) is an uncommon, but potentially lethal, condition. The case of an 83-year-old man with colon cancer who developed chest pain during 5-FU infusion is presented....
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AMP-activated protein kinase Activating Agent and Its Implication

Choi HC

AMP-activated protein kinase (AMPK) is an important cellular fuel sensor. Activation of AMPK requires phosphorylation at threonine (Thr)-172, which resides in the activation loop of the alpha1 and alpha2 subunits....
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Effects of AMP-activated Protein Kinase Activating Compounds and Its Mechanism

Choi HC

AMP-activated protein kinase (AMPK) is an important cellular fuel sensor. Its activation requires phosphorylation at Thr-172, which resides in the activation loop of the alpha1 and alpha2 subunits. Several AMPK...
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Pneumonia from pulmonary aspiration of an antihypertensive anesthetic premedication: A case report

Park SK, Cho EJ

  • KMID: 2263248
  • Anesth Pain Med.
  • 2011 Oct;6(4):402-405.
A 75-year-old man was scheduled for a ray amputation of the left third metatarsal bone. He had a right middle cerebral artery (MCA) territory infarction 6 months earlier and had...
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A case of three-vessel coronary artery spasm presenting with aborted sudden cardiac death

Kim YB, Seol SH, Kim DK, Kim U, Yang TH, Kim DI, Kim DS

  • KMID: 1458435
  • Korean J Med.
  • 2010 Nov;79(5):559-562.
A 51-year-old female patient was referred to the emergency department with a 5-h history of resting chest pain. The patient, who had been diagnosed with variant angina six months previously,...
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Role of T-type Ca2+ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle

Lee SE, Ahn DS, Lee YH

Although extracellular Ca2+ entry through the voltage-dependent Ca2+ channels plays an important role in the spontaneous phasic contractions of the pregnant rat myometrium, the role of the T-type Ca2+ channels...
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A case of gingival hyperplasia caused by felodipine

Park JS, Lee CH, Kim NR, No DH, Kim DH, Choi SY, Jeong JH

  • KMID: 2081662
  • Korean J Med.
  • 2009 Apr;76(Suppl 1):S93-S96.
Felodipine is a calcium channel blocker that is used in the management of hypertension. Calcium channel blockers, along with phenytoin and cyclosporin, are implicated as a cause of gingival hyperplasia....
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The effect of non-surgical treatment in gingival enlargement

Kim SJ, Lee JK, Um HS, Chang BS

PURPOSE: It is well recognized that gingival enlargement is induced by unwanted effect associated with three major drugs/drug groups - phenytoin, cyclosporine, and the calcium channel blockers. The present case...
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Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents

Kim YC, Choi W, Sung R, Kim H, You RY, Park SM, Youn SJ, Kim MJ, Song YJ, Xu WX, Lee SJ, Yun HY

To elucidate the mechanism of cyclic nucleotides, such as adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5' -cyclic monophosphate (cGMP), in the regulation of human gastric motility, we examined the effects...
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