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NAD + and Vascular Dysfunction: From Mechanisms to Therapeutic Opportunities

Abdellatif M, Bugger H, Kroemer G, Sedej S

Nicotinamide adenine dinucleotide (NAD + ) is an essential and pleiotropic coenzyme involved not only in cellular energy metabolism, but also in cell signaling, epigenetic regulation, and post-translational protein modifications....
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Nicotinamide phosphoribosyltransferase regulates the cell differentiation and mineralization in cultured odontoblasts

Kang KR, Kim JS, Seo JY, Lim H, Kim TH, Yu SK, Kim HJ, Kim CS, Chun HS, Park JC, Kim DK

The aim of the present study was to investigate the physiological role of nicotinamide phosphoribosyltransferase (NAMPT) associated with odontogenic differentiation during tooth development in mice. Mouse dental papilla cell-23 (MDPC-23)...
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Nicotinamide adenine dinucleotide phosphate oxidase inhibitor induces apoptosis on EpsteinBarr virus positive B lymphoma cells

Ryu CH, Kim SH, Hur DY

Over-expression of nicotinamide adenine dinucleotide phosphate oxidase (Nox) isoform enzymes was recently reported in various cancers including Burkitt’s lymphoma (BL). However, the functions of Nox isoform enzymes in BL remain...
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Plasma Apelin, Visfatin and Resistin Levels in Patients with First Episode Psychosis and Chronic Schizophrenia

Sahpolat M, Ari M, Kokacya MH

Objective: This study aims to investigate the possible relationship between plasma concentrations of apelin, visfatin and resistin levels of first episode psychosis patients and chronic schizophrenia patients. Methods: A total number...
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Recent trends in two-photon auto-fluorescence lifetime imaging (2P-FLIM) and its biomedical applications

Ranawat H, Pal S, Mazumder N

Two photon fluorescence microscopy and the numerous technical advances to it have served as valuable tools in biomedical research. The fluorophores (exogenous or endogenous) absorb light and emit lower energy...
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The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats

Safhi MM, Anwer T, Khan G, Siddiqui R, Moni Sivakumar S, Alam MF

The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines...
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Enhancement of Replication and Differentiation Potential of Human Bone Marrow Stem Cells by Nicotinamide Treatment

Ok JS, Song SB, Hwang ES

BACKGROUND AND OBJECTIVES: Therapies using mesenchymal stem cells (MSCs) generally require substantial expansion of cell populations. However, the replicative life span of MSCs is limited and their multipotency declines over...
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Serum visfatin levels in non-obese women with polycystic ovary syndrome and matched controls

Kim JJ, Choi YM, Hong MA, Kim MJ, Chae SJ, Kim SM, Hwang KR, Yoon SH, Ku SY, Suh CS, Kim SH

OBJECTIVE: The purpose of the current study was to compare the circulating levels of visfatin between women with polycystic ovary syndrome (PCOS) and those without PCOS and to assess the...
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Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease

Boutari C, Perakakis , Mantzoros

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting 30% of the general population and 40% to 70% of obese individuals. Adipose tissue plays a crucial role in...
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Inhibition of Nicotinamide Phosphoribosyltransferase Induces Apoptosis in Estrogen Receptor-Positive MCF-7 Breast Cancer Cells

Alaee M, Khaghani S, Behroozfar K, Hesari Z, Ghorbanhosseini SS, Nourbakhsh M

PURPOSE: Tumor cells have increased turnover of nicotinamide adenine dinucleotide (NAD⁺), the main coenzyme in processes including adenosine diphosphate-ribosylation, deacetylation, and calcium mobilization. NAD⁺ is predominantly synthesized in human cells...
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Effects of Hydro-Alcoholic Extract of Rhus coriaria (Sumac) Seeds on Reproductive Complications of Nicotinamide-Streptozotocin Induced Type-2 Diabetes in Male Mice

Ahangarpour A, Oroojan AA, Heidari H, Ehsan G, Rashidi Nooshabadi MR

PURPOSE: The purpose of this study was to investigate the effects of the hydro-alcoholic extract of Rhus coriaria seeds on the reproductive system of nicotinamide-streptozotocin-induced type-2 diabetic mice. MATERIALS AND METHODS:...
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Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation

Wang Y

Ageing is the most significant risk factor for a range of prevalent diseases, including cancer, cardiovascular disease, and diabetes. Accordingly, interventions are needed for delaying or preventing disorders associated with...
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Elevated Serum Levels of Visfatin in Patients with Henoch-Schonlein Purpura

Cao N, Chen T, Guo ZP, Li MM, Jiao XY

  • KMID: 2368149
  • Ann Dermatol.
  • 2014 Jun;26(3):303-307.
BACKGROUND: Henoch-Schonlein purpura (HSP) is an immune complex-mediated disease predominantly characterized by the deposition of circulating immune complexes containing immunoglobulin A (IgA) on the walls of small vessels. Although the...
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The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats

Park HJ, Shim HS, Kim KS, Shim I

Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of...
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The Role of Visfatin in Diabetic Nephropathy

Kang YS, Cha DR

As a result of the energy overload in obesity, insulin resistance, type 2 diabetes, dyslipidemia, hypertension, and atherosclerosis develop, which together comprise the metabolic syndrome. Although the kidney becomes a...
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Clinical Utility of Pre-B-Cell Colony-Enhancing Factor in Bronchoalveolar Lavage Fluid of Acute Critical Ill Patients with Lung Infiltrates

Lee K, Hong SB

  • KMID: 2319276
  • Tuberc Respir Dis.
  • 2009 Nov;67(5):402-408.
BACKGROUND: Pre-B-cell colony enhancing factor (PBEF) has been suggested as a novel biomarker in sepsis and acute lung injury. We measured the PBEF in bronchoalveolar lavage (BAL) fluid of acute...
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TNF-alpha stimulated IL-8 and IL-10 expression in monocytes from patients with chronic granulomatous disease

Shin KS

PURPOSE: Patients with chronic granulomatous disease (CGD) have genetic mutations in a component of the NADPH oxidase enzyme that is necessary for the generation of the superoxide anion. The profound...
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Transient downregulation of protein O-N-acetylglucosaminylation by treatment of high-dose nicotinamide in human cells

Lee HI, Cho HJ, Han JA, Jang SY, Wang KM, Kang HT, Hwang ES

Nicotinamide at millimolar concentrations affects cell survival in various conditions, and is being utilized therapeutically in many human diseases. However, the effect of an acute treatment of nicotinamide at such...
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Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification

Lim BH, Cho BI, Kim YN, Kim JW, Park ST, Lee CW

  • KMID: 1098079
  • Exp Mol Med.
  • 2006 Oct;38(5):455-465.
Gastric cancer is one of the most common cancers worldwide. The purpose of this study was to find out potential markers for gastric cancer. Tumor and normal tissues from 152...
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Nicotinamide Reduces the Infarct Volume in a Rat Model of Transient Middle Cerebral Artery Occlusion

Lee MS, Ahn YJ, Choi KY, Kang G, Kang SS, Cheong IY, Lee KJ, Kim KW

  • KMID: 2277678
  • Korean J Pathol.
  • 2006 Apr;40(2):93-102.
BACKGROUND: Cerebral ischemia depletes ATP and causes irreversible tissue injury. Nicotinamide is a precursor of NAD+ and it is also a poly (ADP-ribose) polymerase (PARP) inhibitor that increases the neuronal...
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