- Neuroprotective effects of urolithin A on Hâ‚‚Oâ‚‚-induced oxidative stress-mediated apoptosis in SK-N-MC cells
-
Kim KB, Lee S, Kim JH
- KMID: 2468507
- Nutr Res Pract.
- 2020 Feb;14(1):3-11.
- doi: 10.4162/nrp.2020.14.1.3
BACKGROUND/OBJECTIVES: Oxidative stress causes cell damage and death, which contribute to the pathogenesis of neurodegenerative diseases. Urolithin A (UA), a gut microbial-derived metabolite of ellagitannins and ellagic acid, has high... -
- CITED
-
- Close
- SHARE
-
- Close
- β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice
-
Ye JY, Li L, Hao QM, Qin Y, Ma CS
- KMID: 2466568
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):39-46.
- doi: 10.4196/kjpp.2020.24.1.39
Alzheimer's disease (AD) is the most common neurodegenerative disorder causing dementia worldwide, and is mainly characterized by aggregated β-amyloid (Aβ). Increasing evidence has shown that plant extracts have the potential... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats
-
Lee B, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2466567
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):27-37.
- doi: 10.4196/kjpp.2020.24.1.27
Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but... -
- CITED
-
- Close
- SHARE
-
- Close
- Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons
-
Yoo JY, Kim HB, Yoo SY, Yoo HI, Song DY, Baik TK, Lee JH, Woo RS
- KMID: 2466700
- Anat Cell Biol.
- 2019 Dec;52(4):462-468.
- doi: 10.5115/acb.19.210
The hippocampus is one of the most important brain areas of cognition. This region is particularly sensitive to hypoxia and ischemia. Neuregulin-1 (NRG1) has been shown to be able to... -
- CITED
-
- Close
- SHARE
-
- Close
- Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl2-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells
-
Yoo SY, Yoo JY, Kim HB, Baik TK, Lee JH, Woo RS
- KMID: 2467319
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S111-S118.
- doi: 10.5213/inj.1938190.095
PURPOSE: Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain. The aim of the present... -
- CITED
-
- Close
- SHARE
-
- Close
- Cordycepin protects against β-amyloid and ibotenic acid-induced hippocampal CA1 pyramidal neuronal hyperactivity
-
Yao LH, Wang J, Liu C, Wei S, Li G, Wang S, Meng W, Liu ZB, Huang LP
- KMID: 2461041
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):483-491.
- doi: 10.4196/kjpp.2019.23.6.483
Cordycepin exerts neuroprotective effects against excitotoxic neuronal death. However, its direct electrophysiological evidence in Alzheimer's disease (AD) remains unclear. This study aimed to explore the electrophysiological mechanisms underlying the protective... -
- CITED
-
- Close
- SHARE
-
- Close
- Resveratrol modulates the Akt/GSK-3β signaling pathway in a middle cerebral artery occlusion animal model
-
Park DJ, Kang JB, Shah FA, Koh PO
- KMID: 2470008
- Lab Anim Res.
- 2019 Oct;35(3):124-131.
- doi: 10.1186/s42826-019-0019-8
Cerebral ischemia is a major cause of neurodegenerative disease. It induces neuronal vulnerability and susceptibility, and leads to neuronal cell death. Resveratrol is a polyphenolic compound that acts as an... -
- CITED
-
- Close
- SHARE
-
- Close
- SYM 2081 Exerts Neuroprotective Effect Modulating Anti-Apoptosis in the Hypoxic-Ischemic Brain Injury of Neonatal Rats
-
Park JK, Jang YY, Jeong JE, Lee EJ, Choi EJ, Chung HL, Kim WT
- KMID: 2460024
- Perinatology.
- 2019 Sep;30(3):117-125.
- doi: 10.14734/PN.2019.30.3.117
OBJECTIVE: SYM 2081 ((2S,4R)-4-methylglutamic acid), an agonist and functional antagonist of the kainite receptor, has shown a neuroprotective effect in neurodegenerative diseases in adults but little is known concerning perinatal... -
- CITED
-
- Close
- SHARE
-
- Close
- Asiatic Acid Protects Dopaminergic Neurons from Neuroinflammation by Suppressing Mitochondrial ROS Production
-
Chen D, Zhang XY, Sun J, Cong QJ, Chen WX, Ahsan HM, Gao J, Qian JJ
- KMID: 2456218
- Biomol Ther.
- 2019 Sep;27(5):442-449.
- doi: 10.4062/biomolther.2018.188
This study sought to evaluate the effects of Asiatic acid in LPS-induced BV2 microglia cells and 1-methyl-4-phenyl-pyridine (MPPâº)-induced SH-SY5Y cells, to investigate the potential anti-inflammatory mechanisms of Asiatic acid in... -
- CITED
-
- Close
- SHARE
-
- Close
- Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro
-
He MT, Lee AY, Park CH, Cho EJ
- KMID: 2453105
- Nutr Res Pract.
- 2019 Aug;13(4):279-285.
- doi: 10.4162/nrp.2019.13.4.279
BACKGROUND/OBJECTIVES: Excessive production of reactive oxygen species (ROS) such as hydroxyl (·OH), nitric oxide (NO), and hydrogen peroxide (H2O2) is reported to induce oxidative stress. ROS generated by oxidative stress... -
- CITED
-
- Close
- SHARE
-
- Close
- The Anti-Inflammatory Effect of Sulforaphane in Mice with Experimental Autoimmune Encephalomyelitis
-
Yoo IH, Kim MJ, Kim J, Sung JJ, Park ST, Ahn SW
- KMID: 2452635
- J Korean Med Sci.
- 2019 Jul;34(28):e197.
- doi: 10.3346/jkms.2019.34.e197
BACKGROUND: Multiple sclerosis (MS) is an immune-associated inflammatory disorder of the central nervous system and results in serious disability. Although many disease-modifying therapy drugs have been developed, these drugs have... -
- CITED
-
- Close
- SHARE
-
- Close
- Chemical Constituents of Impatiens balsamina Stems and Their Biological Activities
-
Kim DH, Lee TH, Subedi L, Kim SY, Lee KR
- KMID: 2452782
- Nat Prod Sci.
- 2019 Jun;25(2):130-135.
- doi: 10.20307/nps.2019.25.2.130
The purification of the MeOH extract from Impatiens balsamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2 – 12).... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Chronic and Acute Lithium Treatment on the Long-term Potentiation and Spatial Memory in Adult Rats
-
Yousef M, Kavraal Å, Artış AS, Süer C
- KMID: 2456726
- Clin Psychopharmacol Neurosci.
- 2019 Mar;17(2):233-243.
- doi: 10.9758/cpn.2019.17.2.233
OBJECTIVE: Although, accumulating evidence is delineating a neuroprotective and neurotrophic role for lithium (Li), inconsistent findings have also been reported in human studies especially. Moreover, the effects of Li infusion... -
- CITED
-
- Close
- SHARE
-
- Close
- Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
-
Park JS, Leem YH, Park JE, Kim DY, Kim HS
- KMID: 2442009
- Biomol Ther.
- 2019 Feb;27(2):178-184.
- doi: 10.4062/biomolther.2018.234
Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether β-Lapachone (β-LAP), a... -
- CITED
-
- Close
- SHARE
-
- Close
- Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis
-
Sapkota A, Park SJ, Choi JW
- KMID: 2442006
- Biomol Ther.
- 2019 Feb;27(2):152-159.
- doi: 10.4062/biomolther.2018.089
Multiple sclerosis (MS) is an autoimmune disease characterized by progressive neuronal loss, neuroinflammation, axonal degeneration, and demyelination. Previous studies have reported that 6-shogaol, a major constituent of ginger (Zingiber officinale... -
- CITED
-
- Close
- SHARE
-
- Close
- Neuroprotective Effects of Spinosin on Recovery of Learning and Memory in a Mouse Model of Alzheimer's Disease
-
Xu F, He B, Xiao F, Yan T, Bi K, Jia Y, Wang Z
- KMID: 2432069
- Biomol Ther.
- 2019 Jan;27(1):71-77.
- doi: 10.4062/biomolther.2018.051
Previous studies have shown that spinosin was implicated in the modulation of sedation and hypnosis, while its effects on learning and memory deficits were rarely reported. The aim of this... -
- CITED
-
- Close
- SHARE
-
- Close
- Hyperglycemia aggravates decrease in alpha-synuclein expression in a middle cerebral artery occlusion model
-
Kang JB, Kim DK, Park DJ, Shah MA, Kim MO, Jung EJ, Lee HS, Koh PO
- KMID: 2459295
- Lab Anim Res.
- 2018 Dec;34(4):195-202.
- doi: 10.5625/lar.2018.34.4.195
Hyperglycemia is one of the major risk factors for stroke. Hyperglycemia can lead to a more extensive infarct volume, aggravate neuronal damage after cerebral ischemia. α-Synuclein is especially abundant in... -
- CITED
-
- Close
- SHARE
-
- Close
- Siegesbeckia Orientalis L. Extract Attenuates Postoperative Cognitive Dysfunction, Systemic Inflammation, and Neuroinflammation
-
Chu JM, Xiong W, Linghu KG, Liu Y, Zhang Y, Zhao GD, Irwin MG, Wong GT, Yu H
- KMID: 2430112
- Exp Neurobiol.
- 2018 Dec;27(6):564-573.
- doi: 10.5607/en.2018.27.6.564
A proportion of patients experience acute or even prolonged cognitive impairment after surgery, a condition known as postoperative cognitive dysfunction (POCD). It is characterized by impairment in different cognitive domains... -
- CITED
-
- Close
- SHARE
-
- Close
- Diverse Ischemic Postconditioning Protocols Affect the Infarction Size in Focal Ischemic Stroke
-
Lee JS, Song DJ, Hong JH, Kim TS, Joo SP
- KMID: 2422767
- J Cerebrovasc Endovasc Neurosurg.
- 2018 Sep;20(3):159-167.
- doi: 10.7461/jcen.2018.20.3.159
OBJECTIVE: Ischemic postconditioning (IPostC), consisted of transient brain ischemia/reperfusion cycles, is considered to have neuroprotective effect. However, there is no best single protocol of IPostC, because varied factors like species... -
- CITED
-
- Close
- SHARE
-
- Close
- Acer okamotoanum Inhibit the Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells
-
Choi SY, Kim JH, Quilantang NG, Lee S, Cho EJ
- KMID: 2422005
- Nat Prod Sci.
- 2018 Sep;24(3):148-154.
- doi: 10.20307/nps.2018.24.3.148
Chronic oxidative stress due to the accumulation of reactive oxygen species (ROS) in neuronal cells ultimately leads to neurodegenerative diseases. The use of natural therapies for the prevention of ROS-induced... -
- CITED
-
- Close
- SHARE
-
- Close
