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Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies

Kwon S, Iba M, Masliah E, Kim C

Synucleinopathies are neurodegenerative disorders characterized by the progressive accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In this review,...
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A Case of Cerebral Cysticercosis in Thailand

Thammachantha S, Kunnatiranont R, Polpong P

Cysticercosis and sparganosis are not uncommon parasitic infections in the developing world. Central nervous system infection by both cestodes can present with neurological signs and symptoms, such as seizure and...
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Fine Dust and Dementia: Is Ambient Air Pollution Associated with Cognitive Health?

Han SH

Air pollution is a growing global health concern estimated to contribute to as many as 4.2 million premature deaths worldwide per year. So it poses the greatest environmental risk to...
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Myelin Water Fraction MRI in a Case of Clinically Probable Amyotrophic Lateral Sclerosis

Yang J, Lee J, Kim E, Shin DH

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that clinically manifests both upper and lower motor neuron signs. However, it is unknown where and how the motor...
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DNA damage to human genetic disorders with neurodevelopmental defects

Lee Y, Choi I, Kim J, Kim K

Although some mutations are beneficial and are the driving force behind evolution, it is important to maintain DNA integrity and stability because it contains genetic information. However, in the oxygen-rich...
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Cystic Meningiomas: Correlation between Radiologic and Histopathologic Features

Go KO, Lee K, Heo W, Lee YS, Park YS, Kim SK, Lee JH, Jung JM

BACKGROUND: Tumors with cysts often correlate with gliomas, metastatic tumors, or hemangioblastomas, which require differentiation. METHODS: Thirty-eight cases of cyst associated-meningioma based on preoperative radiologic studies and histologic confirmations were reviewed...
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Primary Progressive Aphasia and the Left Hemisphere Language Network

Mesulam MM

Primary progressive aphasia (PPA) is a clinical syndrome diagnosed when three core criteria are met. First, there should be a language impairment (i.e., aphasia) that interferes with the usage or...
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Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy

Bi B, Choi HP, Hyeon SJ, Sun S, Su N, Liu Y, Lee J, Kowall NW, McKee AC, Yang JH, Ryu H

Chronic traumatic encephalopathy (CTE) is a distinct neurodegenerative disease that associated with repetitive head trauma. CTE is neuropathologically defined by the perivascular accumulation of abnormally phosphorylated tau protein in the...
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The Brain Donation Program in South Korea

Kim Y, Suh YL, Kim SJ, Bae MH, Kim JB, Kim Y, Choi KC, Huh GY, Kim EJ, Lee JS, Kang HW, Shim SM, Lim HJ, Koh YH, Kim BC, Lee KH, Lee MC, Lee HW, Lim TS, Seeley WW, Kim HJ, Na DL, Lee KH, Seo SW

PURPOSE: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia...
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Role of Positron Emission Tomography as a Biologic Marker in the Diagnosis of Primary Progressive Aphasia: Two Case Reports

Jeong YJ, Park KW, Kang DY

Primary progressive aphasia (PPA) is a heterogenous neurodegenerative disorder characterized by declining language and speech ability. Various underlying neuropathologies can induce PPA, and the disorder is divided into three subtypes—progressive...
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Thick Corpus Callosum in Children

Schupper A, Konen O, Halevy A, Cohen R, Aharoni S, Shuper A

BACKGROUND AND PURPOSE: A thick corpus callosum (TCC) can be associated with a very grave outcome in fetuses, but its clinical presentation in older children seems to be markedly different. METHODS:...
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Unified principles of thalamo-cortical processing: the neural switch

Ribary U, Doesburg S, Ward LM

It has been reported that cross-frequency interactions may play an important role in local processing within thalamus and neocortex, as well as information transfer between subcortical and cortico-cortical brain regions....
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