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Transcriptional Signature of Valproic Acid-Induced Neural Tube Defects in Human Spinal Cord Organoids

Lee JH, Shaker MR, Park SH, Sun W

In vertebrates, the entire central nervous system is derived from the neural tube, which is formed through a conserved early developmental morphogenetic process called neurulation. Although the perturbations in neurulation...
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Spontaneous movements as prognostic tool of neurodevelopmental outcomes in preterm infants: a narrative review

Shin HI, Park MW, Lee WH

An estimated 15 million infants are born prematurely each year. Although the survival rate of preterm infants has increased with advances in perinatal and neonatal care, many still experience various...
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Electroconvulsive Therapy for Treatment-Refractory Behaviors Problems in Neurodevelopmental Disorders

Seo HJ, Lee NY, Lee KY, Bahn GH, Bhang SY, Kim HC, Kim YS, Chung IW

Individuals with developmental disorders exhibit a broad spectrum of aggressive behaviors, including self-directed actions and those directed toward others. These behaviors can lead to physical harm, disruptions in daily life,...
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Early Neurodevelopmental Assessments of Neonates Discharged From the Neonatal Intensive Care Unit: A Physiatrist’s Perspective

Hyun SE, Kwon JY, Hong BY, Yoon JA, Choi JY, Hong J, Koh SE, Ko EJ, Kim SK, Song MK, Yi SH, Cho A, Kwon BS

The survival rate of children admitted in the neonatal intensive care unit (NICU) after birth is on the increase; hence, proper evaluation and care of their neurodevelopment has become an...
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Neurodevelopmental Outcomes and Brain Volumetric Analysis of Low-Grade Intraventricular Hemorrhage

Park SG, Yang HJ, Lim SY, Kim SH, Shin SH, Kim EK, Kim HS

Purpose: Extremely preterm infants are prone to brain injury and underdevelopment. Intraventricular hemorrhage (IVH) is the most common cause of brain injury and a significant risk factor for neurodevelopmental delay...
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The Long-Term Outcome and Rehabilitative Approach of Intraventricular Hemorrhage at Preterm Birth

Hong J, Rha Dw

Technological advances in neonatology led to the improvement of the survival rate in preterm babies with very low birth weights. However, intraventricular hemorrhage (IVH) has been one of the major...
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Fetal arachnoid cyst: characteristics, management in pregnancy, and neurodevelopmental outcomes

Hong S, Pae J, Ko HS

Arachnoid cysts are rarely found during the prenatal period and can exist in any part of the brain as extra-axial cysts. These cysts are usually found after the second trimester...
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Variant of CHD1 gene resulting in a Korean case of Pilarowski-Bjornsson syndrome

Sunwoo Y, Seo SH, Kim HJ, Park MS, Cho A

Many monogenic neurodevelopmental disorders have been newly identified in recent years owing to the rapid development of genetic sequencing technology. These include variants of the epigenetic machinery – up to...
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Influence of Maternal Diabetes on the Risk of Neurodevelopmental Disorders in Offspring in the Prenatal and Postnatal Periods

Perea V, Urquizu X, Valverde M, Macias M, Carmona A, Esteve E, Escribano G, Pons N, Giménez O, Gironés T, Simó-Servat A, Domenech A, Alonso-Carril N, Quirós C, Amor AJ, López E, Barahona MJ

Background: This study aimed to evaluate the influence of maternal diabetes in the risk of neurodevelopmental disorders in offspring in the prenatal and postnatal periods. Methods: This cohort study included singleton...
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Probability of Transition to Psychosis and Bipolar Disorder in Individuals With Neurodevelopmental Disorders

An S, Choi BS, Yu ER, Jeong JW, Huh SY

Objectives: The clinical trajectories of adolescent-onset psychosis and bipolar disorder are worse than that of adult-onset cases. Although psychosis and bipolar disorder are more prevalent among those with neurodevelopmental disorders...
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Hearing and Neurodevelopmental Out comes in Preterm Infants with Post­natal Cytomegalovirus Infection

Kim YJ, Shin SH, Kim EK, Kim HS

Objective: We aimed to investigate whether preterm infants with postnatal cytomegalovirus (CMV) infection have unfavorable hearing and neurodevelopmental outcomes. We also tried to find the difference between symptomatic and asymptomatic...
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Effects of a Sociodrama-based Communication Enhancement Program on Mothers of Children with Neurodevelopmental Disorders: A Pilot Study

Jang SJ, Han JS, Bang MH, Ahn JW

Purpose: The incidence and prevalence of neurodevelopmental disorders have rapidly increased, indicating an urgent need for assistance through parenting interventions. This study aimed to evaluate the effects of a sociodrama-based...
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A 24-Month Effects of Methylphenidate Use on Growth in Children and Adolescents With Attention Deficit Hyperactivity Disorder

Lee Y, Kong N, Koo S, Bai DS, Kim Hj, Jeong H, Seo WS

Objective The primary objective of this study was to investigate the effect of methylphenidate (MPH) on height, weight, and body mass index (BMI) in drug-naive children and adolescents with attention...
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Increased Serum Level of CCL5 in Children with Attention‑Deficit/ Hyperactivity Disorder: First Results about Serum Chemokines

Özaslan A, Güney E, Gülbahar Ö, Büyüktaskin D, Arslan B

Objective: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder and its aetiology is not fully understood. This study aimed to determine whether the CCL5 and CCL11 influence the ADHD...
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Region Specific Brain Organoids to Study Neurodevelopmental Disorders

Susaimanickam PJ, Kiral FR, Park IH

Region specific brain organoids are brain organoids derived by patterning protocols using extrinsic signals as opposed to cerebral organoids obtained by self-patterning. The main focus of this review is to...
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Development of the Parental Questionnaire for Cerebral Visual Impairment in Children Younger than 72 Months

Moon JH, Kim GH, Kim SK, Kim S, Kim YH, Kim J, Kim JK, Noh BH, Byeon JH, Yeom JS, Eun BL, Eun SH, Choi J, Chung HJ

Background and Purpose: Cerebral visual impairment (CVI) is an underdiagnosed condition in children, and its assessment tools have focused on older children. We aimed to develop a parental questionnaire for...
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The Efficacy of Early Start Denver Model Intervention in Young Children with Autism Spectrum Disorder Within Japan: A Preliminary Study

Tateno Y, Kumagai K, Monden R, Nanba K, Yano A, Shiraishi E, Teo AR, Tateno M

Objectives: Among the many intervention programs for children with autism spectrum disorder (ASD), the Early Start Denver Model (ESDM) is one of the few approaches that has succeeded in demonstrating...
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Neuroimaging-Based Deep Learning in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder

Song JW, Yoon NR, Jang SM, Lee GY, Kim BN

  • KMID: 2504040
  • J Korean Acad Child Adolesc Psychiatry.
  • 2020 Jul;31(3):97-104.
  • doi: 10.5765/jkacap.200021
Deep learning (DL) is a kind of machine learning technique that uses artificial intelligence to identify the characteristics of given data and efficiently analyze large amounts of information to perform...
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Shprintzen–Goldberg syndrome with a novel missense mutation of SKI in a 6-month-old boy

Jeon MJ, Park SG, Kim MJ, Lim BC, Kim KJ, Chae JH, Kim SY

The Shprintzen–Goldberg syndrome (SGS) is an extremely rare genetic disorder caused by heterozygous variant in SKI . SGS is characterized by neurodevelopmental impairment with skeletal anomaly. Recognition of SGS is...
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Magnesium Status in Children with Attention-Deficit/Hyperactivity Disorder and/or Autism Spectrum Disorder

Skalny AV, Mazaletskaya AL, Ajsuvakova OP, Bjørklund G, Skalnaya MG, Chernova LN, Skalny AA, Tinkov AA

Objective: The objective of this study was to assess serum, hair, and urinary magnesium (Mg) levels in children with attention-deficit/ hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and both ASD...
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