- The role of oxidative stress and hypoxia in renal disease
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Honda T, Hirakawa Y, Nangaku M
- KMID: 2469372
- Kidney Res Clin Pract.
- 2019 Dec;38(4):414-426.
- doi: 10.23876/j.krcp.19.063
Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are constantly released during mitochondrial oxygen consumption for energy production. Any imbalance between ROS production and its scavenger system... -
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- Exploring molecular targets in diabetic kidney disease
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Maruno S, Tanaka T, Nangaku M
- KMID: 2535411
- Kidney Res Clin Pract.
- 2022 Sep;41(Suppl 2):S33-S45.
- doi: 10.23876/j.krcp.21.251
Diabetic kidney disease is the leading cause of end-stage kidney disease, and it remains a major challenge. Many factors, such as glomerular hyperfiltration, oxidative stress, inflammation, hypoxia, and epigenetics, are... -
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- Treatment of Diabetic Kidney Disease: Current and Future
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Yamazaki T, Mimura I, Tanaka T, Nangaku M
- KMID: 2514070
- Diabetes Metab J.
- 2021 Jan;45(1):11-26.
- doi: 10.4093/dmj.2020.0217
Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However, only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD. In 2019, sodium-glucose cotransporter 2 (SGLT2)... -
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- The role of renal proximal tubule transport in the regulation of blood pressure
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Horita S, Nakamura M, Suzuki M, Satoh N, Suzuki A, Homma Y, Nangaku M
- KMID: 2409385
- Kidney Res Clin Pract.
- 2017 Mar;36(1):12-21.
- doi: 10.23876/j.krcp.2017.36.1.12
The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis. Mutations in the gene encoding NBCe1 cause... -
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