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Exploring molecular targets in diabetic kidney disease

Maruno S, Tanaka T, Nangaku M

Diabetic kidney disease is the leading cause of end-stage kidney disease, and it remains a major challenge. Many factors, such as glomerular hyperfiltration, oxidative stress, inflammation, hypoxia, and epigenetics, are...
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Treatment of Diabetic Kidney Disease: Current and Future

Yamazaki T, Mimura I, Tanaka T, Nangaku M

Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However, only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD. In 2019, sodium-glucose cotransporter 2 (SGLT2)...
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The role of oxidative stress and hypoxia in renal disease

Honda T, Hirakawa Y, Nangaku M

Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are constantly released during mitochondrial oxygen consumption for energy production. Any imbalance between ROS production and its scavenger system...
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The role of renal proximal tubule transport in the regulation of blood pressure

Horita S, Nakamura M, Suzuki M, Satoh N, Suzuki A, Homma Y, Nangaku M

The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis. Mutations in the gene encoding NBCe1 cause...
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